Læknablaðið : fylgirit - 01.10.1980, Blaðsíða 27

21
The intergrated pathogenesis of imniune
inflammation
When the four different models for ex-
planation of immunological inflammatory
tissue damage have been presented, it is
necessary to understand that the descrip-
tion with a subclassification into four
different types of reactivity i's of a some-
what dogmatic nature. Usually, immuno-
logical inflammation is a combined mix-
ture of all four pathogenetic patterns, and
it is not possible to attribute the inflamma-
tory tissue reaction to one single type of
mechanism. Only in diseases due to type I
reactivity this is sometimes the case. In
infectious diseases, skin diseases, inflamma-
tory connective tissue, diseases, internal
medical disorders with immunological
pathogenesis and in drug hypersensitivities
we usually find a complex combination of
several mechanisms. Drug hypersensitivity
for instance can very often be demonstrated
to be due to inflammation caused by types
I, II, III and IV at the same time. However,
it is necessary to comprehend and describe
the biological events, which stepwise build
up the immunological inflammation. And
the type I-IV classification system helps us
to do so. When we have learned its rules
and heve tried to use them at various levels
of complexity, it is usually found more
easy to leave their dogmatism and establish
individual pathogenetic explanations for
the immunological damage that occurs in
each individual clinical immune disease.
Abstract:
A lot of detailed information must be
collected before it is possible to establish
whether an inflammatory process is of im-
munological nature and to explain a possi-
ble immunopathogenic mechanism involved
in each individual case of clinical disease.
The type I-IV classification of immune re-
actions is helpful for explaining the various
pattems of immunological inflammatory
tissue reactions and can be a guideline for
investigations that aim at illustrating pat-
hogenetic mechanism. But the pathogene-
ses of the inflammatory immune reaction
are usually coexisting and combined in a
complex manner in each indi'vidual clini-
cal disorder.
Þátttakendur:
Almar Grímsson, Reykjavík
Arinbjöm Kolbeinsson, Reykjavík
A.rnar Þorgeirsson, Reykjavík
Auðbergur Jónsson, Höfn
Árni Kristinsson, Reykjavík
Ársaell Jónsson, Reykjavík
Ásbjörn Sigfússon, Reykjavík
Ásgeir B. Ellertsson, Reykjavík
Bergþóra Sigurðardóttir, Hafnarfirði
Einar Baldvinsson, Reykjavík
Einar Valur Bjarnason, Vestmannaeyjum
Eyjólfur Haraldsson, Kópavogi
Friðbert Jónasson, Reykjavík
F.riðrik Jónsson, Stykkishólmi
Friðrik Sveinsson, Reykjalundi
Gísli Auðunsson, Húsavík
Guðjón Lárusson, Reykjavík
Guðmundur Árnason, Akranesi
Guðmundur Oddsson, Reykjavík
Guðmundur Eyjólfsson, Reykjavík
Guðrún Jónsdóttir, Reykjavík
Guðrún Kristjánsdóttir, Reykjavík
Guðsteinn Þengilsson, Kópavogi
Gunnar Sigm-ðsson, Reykjavík
Gunnsteinn Gunnarsson, Kópavogi
Halldór Halldórsson, Akureyri
Halldór Steinsen, Reykjavík
Hallgrímur Guðjónsson, Reykjavík
Haukur Þórðarson, Reykjalundi
Hjördís Jónsdóttir, Reykjavík
Hreggviður Hermannsson, Keflavík
Inga Björnsdóttir, Akureyri
Ingimar Hjálmarsson, Húsavík
Ingólfur Hjaltalín, Reykjavík
Ingvar J. Karlsson, Reykjavík
Ingvar Teitsson, Reykjavík