Læknablaðið : fylgirit - 01.06.2005, Blaðsíða 20

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ABSTRACTS / XXIX CONGRESS OF THE NORDIC ASSOCIATION OF OTOLARYNGOLOGY
Abstract no.: 031
Surgical treatment for early cancer of the mobile tongue - is
it sufficient?
Antti Makitie, Helsinki University Central Hospital, Finland
Abstract missing
Abstract no.: 032
Radiotherapy for early laryngeal and oral cavity cancers
Cai Grau, Professor, DMSc, Department of Oncology, Aarhus University
Hospital, Aarhus, Denmark
The curative management of early (stage I-II) squamous cell car-
cinomas of the larynx and oral cavity is a matter of great debate,
since both surgery and radiotherapy can result in good local
control. The choice of treatment thus depends on the associated
morbidity.
For oral cavity cancers, external radiotherapy is often
associated with acute side effects like mucositis and pain, and
also a significant risk of chronic xerostomia, dysphagia, or
osteoradionecrosis. Primary surgery with sufficient reconstruction
and dental rehabilitation seems to give less chronic side
effects. Thus, the Danish Head and Neck Cancer Study Group
(DAHANCA) recommends surgery alone for all T1-T2 node
negative patients in our ‘National guideline for management of
oral cancer’, which can be downloaded from www.dshho.dk or
www.dahanca.dk. Postoperative radiotherapy is recommended
in case of insufficient surgical margins. In addition to surgery and
external radiotherapy, it should be mentioned that brachytherapy
with radioactive implants may give tumor control with organ
preservation and few chronic side effects. Good results in
brachytherapy, however, are relying heavily on expertise in both
patient selection and the actual treatment.
In contrast to oral cancer, early laryngeal cancer can be treated
by radiotherapy with very few side effects and excellent local
control. The recent DAHANCA 6&7 trial including over 900
larynx cancer patients, treated with accelerated radiotherapy,
thus showed close to 90% larynx preservation for T1-T2 tumors.
The surgical alternative, laser surgery, has often been suggested
as a less costly and more patient-friendly alternative especially for
glottic tumors. However, the published studies have shown that
the voice quality is either less good after laser excision than after
radiotherapy, or without significant difference. Since all of these
studies are small, a large randomised trial with validated assays of
voice quality, as well as socioeconomic endpoints, is warranted to
settle this long standing discussion.
Abstract no.: 033
Prediction of survival in head and neck cancer
Robert De Baatenburg de Jong, The Netherlands
Abstract missing
Abstract no.: 034
Abstract withdrawn
S-VIII AIRWAY OBSTRUCTION, INGESTION AND INHALATION
Abstract no.: 035
Atopic diseases in the upper airway
Michael Clausen, MD
There is a worldwide concern about the increasing prevalence of
asthma, allergic rhinitis, atopic eczema and food allergy in child-
hood. This increase in prevalence is global but mostly in affluent
countries. These diseases can be substantial burden to those
affected and impair theirs quality of life. They are also closely
related to each other, as rhinitis and eczema are known risk fac-
tors for asthma and eczema can predict rhinitis. In some western
countries, asthma and allergies are affecting up to one-third of
children and is some of the major causes of morbidity. Allergic
rhinitis often starts in childhood with increasing prevalence with
age. It is the most common allergic disease and leading chronic
condition in children. The most common seasonal allergens are
tree, grass, weed pollens and outdoor mold spores. Dust mites and
pets, like cats and dogs stands for common perennial allergens.
Allergic rhinitis was reported by 17% 10-11 years old Icelandic
school children and 11% reported pollen allergy in the year 2000.
Positive skin prick test was found in 24.9% of the children. The
most common allergen was grass 18.7% and cat 12.9%. This is
similar what was found in Swedish children at same age. Sinusitis
is a common problem though usually caused by infections.
Sinusitis without rhinitis is rare. Allergic rhinitis and grass pollen
sensitization has been postulated as independent risk factors for
sinusitis in children. Otitis media with effusion is more common
in atopic children. Finding of eosinophiles and Th2 mediators in
the middle-ear effusions of atopic children suggests that allergy
might play roll in the pathogeneses of otitis media with effusion.
Food allergy can provoke upper airway respiratory symptoms.
Most commonly rhinitis but also serious symptoms like laryngeal
spasm. These symptoms typically occur in association with other
clinical manifestations. The role of food allergy in recurrent otitis
media with effusion has been proposed but is controversial.
Abstract no.: 036
Respiratory tract infections and wheezing
Sigurður Kristjánsson, Iceland
Background: Respiratory syncytial virus infections during infancy
are considered to be a risk factor for developing asthma and
possibly allergic sensitization. Also association between severe
infant bronchiolitis due to respiratory syncytial virus (RSV) and
subsequent wheezing is well-documented. High levels of urinary
eosinophil protein X (U-EPX) have been related to active disease
in asthmatic children.
Objective: In one study we have investigated cytokines, chemo-
kines and Eosinophil Cationic Protein in nasopharyngeal secre-
:0 Læknablaðið/Fylgirit 51 2005/91