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Læknablaðið - 01.03.2023, Blaðsíða 16

Læknablaðið - 01.03.2023, Blaðsíða 16
132 L ÆKNABL AÐIÐ 2023/109 R A N N S Ó K N ingunartími kvikasilfurs er langur má færa rök fyrir því að rétt sé að kynna slíkar ráðleggingar fyrir konum á barneignaraldri. Þakkir Við viljum þakka ljósmæðrum Heilsugæslu höfuðborgarsvæð- isins fyrir gott samstarf við framkvæmd rannsóknarinnar sem, þrátt fyrir miklar annir á tímum heimsfaraldurs, gáfu sér tíma í þetta verkefni og leystu það af metnaði. Við viljum einnig þakka þátttakendum sem gáfu sér tíma til að sitja undir fræðslu, svara spurningalistum og gefa hársýni. Án þeirra hefði þessi rannsókn ekki verið möguleg. Greinin barst til blaðsins 28. ágúst 2022, samþykkt til birtingar 3. febrúar 2023. Heimildir 1. Environment U. GLOBAL MERCURY ASSESSMENT 2018 UN .Environment Programme Chemicals and Health Branch. Genf, Sviss 2019. 2. EFSA. Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food. EFSA J 2012; 10 (12). 3. Stern AH, Smith AE. An assessment of the cord blood:maternal blood methylmercury ratio: implications for risk assessment. Environ Health Perspect 2003; 111: 1465-70. 4. Harada M. Minamata disease: methylmercury poisoning in Japan caused by environ- mental pollution. Crit Rev Toxicol 1995; 25: 1-24. 5. Grandjean P, Weihe P, White RF, et al. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 1997; 19: 417-28. 6. Debes F, Weihe P, Grandjean P. Cognitive deficits at age 22 years associated with prenatal exposure to methylmercury. Cortex 2016; 74: 358-69. 7. Jacobson JL, Muckle G, Ayotte P, et al. Relation of Prenatal Methylmercury Exposure from Environmental Sources to Childhood IQ. Environ Health Perspect 2015; 123: 827-33. 8. Davidson PW, Myers GJ, Cox C, et al. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. JAMA 1998; 280: 701-7. 9. US-EPA. Integrated Risk Information System. Methylmercury (MeHg). Chemical Assessment Summary 2001; (CASRN 22967-2-6). - desember 2022. 10. Toxicological Effects of Methylmercury. Washington (DC) 2000. 11. National Board of Health D. Healthy habits before, during and after pregnancy. 2015. sst.dk/-/media/Udgivelser/2017/Sunde-vaner-før-under-og-efter-graviditet/Sunde_vaner. ashx - desember 2022. 12. National Health Service. Foods to avoid in pregnancy. 2020. nhs.uk/pregnancy/keeping well/foods-to-avoid/ - desember 2022. 13. Mataræði á meðgöngu: Fróðleikur fyrir konur á barneignaraldri. Embætti landlæknis í samstarfi við Matvælastofnun, Mæðravernd Þróunarstofu heilsugæslu höfuðborgarsvæð- isins og Rannsóknastofu í næringarfræði, Reykjavík 2018. 14. Adlard B, Lemire M, Bonefeld-Jorgensen EC, et al. MercuNorth - monitoring mercury in pregnant women from the Arctic as a baseline to assess the effectiveness of the Minamata Convention. Int J Circumpolar Health 2021; 80: 1881345. 15. Den Hond E, Govarts E, Willems H, et al. First steps toward harmonized human biomon- itoring in Europe: demonstration project to perform human biomonitoring on a European scale. Environ Health Perspect 2015; 123: 255-63. 16. Packull-McCormick S, Ratelle M, Lam C, et al. Hair to blood mercury concentration ratios and a retrospective hair segmental mercury analysis in the Northwest Territories, Canada. Environ Res 2022; 203: 111800. 17. Castano A, Pedraza-Diaz S, Canas AI, et al. Mercury levels in blood, urine and hair in a nation-wide sample of Spanish adults. Sci Total Environ 2019; 670: 262-70. 18. Jónsdóttir AH, SH Lund. Tölfræði frá grunni. Háskóli Íslands, Reykjavík 2022. 19. McKelvey W, Jeffery N, Clark N, et al. Population-based inorganic mercury biomonitoring and the identification of skin care products as a source of exposure in New York City. Environ Health Perspect 2011; 119: 203-9. 20. Partearroyo T, Samaniego-Vaesken ML, Ruiz E, et al. Current Food Consumption amongst the Spanish ANIBES Study Population. Nutrients 2019; 11: 2663. 21. Gunnarsdóttir S, Þorgeirsdóttir H, Torfadóttir JE, et al. Hvað borða Íslendingar? Embætti landlæknis og Rannsóknastofa í næringarfræði við Háskóla Íslands, Reykjavík 2022. 22. Sanzo JM, Dorronsoro M, Amiano P, et al. Estimation and validation of mercury intake associated with fish consumption in an EPIC cohort of Spain. Public Health Nutr 2001; 4: 981-8. 23. Reykdal Ó, Desnica N, Hauksdóttir S, et al. Næringargildi sjávarafurða. Meginefni, stein- efni, snefilefni og fitusýrur í lokaafurðum. Matís, Reykjavík 2011. 24. McMeans BC, Arts MT, Fisk AT. Impacts of food web structure and feeding behavior on mercury exposure in Greenland Sharks (Somniosus microcephalus). Sci Total Environ 2015; 509-10: 216-25. 25. Newman MC, Xu X, Cotton CF, et al. High mercury concentrations reflect trophic ecology of three deep-water chondrichthyans. Arch Environ Contam Toxicol 2011; 60: 618-25. 26. Jo S, Woo HD, Kwon HJ, et al. Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model. Int J Environ Res Public Health 2015; 12 : 9054- 67. 27. Kirk LE, Jorgensen JS, Nielsen F, et al. Public health benefits of hair-mercury analysis and dietary advice in lowering methylmercury exposure in pregnant women. Scand J Public Health 2017; 45: 444-51. 28. Bhandare D, Ruchi R. Unusual complication of an Alaskan cruise: thinking outside the box. BMJ Case Rep 2019; 12: e227727. 29. Risher JF. Too much of a good thing (fish): methylmercury case study. J Environ Health 2004; 67: 9-14, 28. 30. Knobeloch LM, Ziarnik M, Anderson HA, et al. Imported seabass as a source of mercury exposure: a Wisconsin case study. Environ Health Perspect 1995; 103: 604-6. E N G L I S H S U M M A R Y Levels of mercury in hair among pregnant women in Iceland INTRODUCTION: To limit exposure to methylmercury several countries have implimented specific advice on fish intake to pregnant women as well a measuring compliance through regular human biomonitoring. Despite fish intake being relatively high in Iceland, human biomonitoring data on mercury is scarce. MATERIALS AND MEHODS: We measured mercury in hair from 120 pregnant women recruited in 2021 from the the Reykjavik Capital area. At recruitment, information on fish intake during the past four months was recorded. Hair mercury concentrations were compared to existing health based guidance values and associatons with fish intake was explored. RESULTS: Mean (standard deviation) mercury concentration in hair was 0.48 μg/g (0.33). All participants had concentrations in hair below 1.8 μg/g, which corresponds to the hair value that the tolerable daily intake set by the European Food Safety Authority is derived from, while 5% had concentrations above 1.1 μg/g, which corresponds to the hair value that the US-EPA reference dose is derived from. Mean mercury concentrations in hair increased in a dose dependent manner (p for trend <0.001) from 0.25 μg/g among women who consumed fish ≤ 3/month (n=24) and up to 0.80 mg/g among those consuming fish 3-4/ week (n=16). The few (n=3) women who reported to have eaten shark (<1/month) were all at the higher end of the exposure distribution. CONCLUSION: Our results suggest that exposure is generally below the tolerable daily intake set by EFSA but may in some women exceed the reference dose established by the US-EPA. doi 10.17992/lbl.2023.03.733 *Edda Dufþaksdóttir1 *Eva Jacobsen1 Ása Valgerður Eiríksdóttir2 Óla Kallý Magnúsdóttir3 Kristín Ólafsdóttir2 Þórhallur Ingi Halldórsson1 *These authors contributed equally to this work 1Faculty of Food Science and Nutrition, Univeristy of Iceland, 2Department of Pharmacology and Toxicology, University of Iceland, 3Development Centre for Primary Health Care in Iceland. Correspondence: Þórhallur Ingi Halldórsson, tih@hi.is Key words: mercury, seafood, pregnancy, hair, biomonitoring.

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