Læknablaðið - 15.01.1995, Page 47

LÆKNABLAÐIÐ 1995; 81
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Table I. An overview of 468 hyperthyroid patients who had 1311 treatment during 1973-1991.
Year(s) 73-74 75-76 77-78 79-80 81-82 83-84 85-86 87-88 89-90 91*
No of patients 19 20 33 35 40 64 69 67 71 50
Hot nodule 0 2 0 1 3 5 12 5 7 5
Repeated treat- ment % 15.8 25 24.2 28.6 15 6.2 14.5 22.4 19.7 24
*Jan-Oct
Table II. An overview of 422 paiients with Graves' disease who Itad 1311 treatment during 1973-1991.
Year(s) 73-74 75-76 77-78 79-80 81-82 83-84 85-86 87-88 89-90 91*
Mean age 55 54 43 46 47 51 49 48 51 52
Standard dev. ±14 ±12 ±14 ±14 ±13 ±16 ±14 ±12 ±13 ±19
Mean dose(mCi) 5.4 5.1 4.4 6.6 5.7 5.9 5.3 5.3 4.8 5.7
Standard dev. ±1.4 ±1.8 ±1.4 ±2.7 ±1.8 ±2.4 ±1.7 ±1.2 ±1.7 ±2.3
Mean weight of gland
by palpation 38 34 32 48 39 39 35 33 31 33
Standard dev. ±16 ±13 ±15 ±27 ±19 ±22 ±13 ±9 ±12 ±10
Mean iodine upt,
4h/24h 47/62 42/60 56/66 53/63 47/60 40/58 49/61 46/60 44/56 44/60
Standard dev. ±15/12 ±16/11 ±17/11 ±21/13 ±20/18 ±17/14 ±21/16 ±19/13 ±18/16 ±22/17
*Jan-Oct
Table III. Some means and standard deviations for four groups ofpatients before treatment; I) Graves'disease (GD) patients,
one treatment, 11) GD patients, more than one treatment, III) toxic adenoma, one treatment, IV) toxic multinodular glands.
No. of patients Age Weight of gland Dosis mCi Dosis uptake uCi/g 4h uptake 24h uptake 4/24 uptake
I) 342 51 34 5.4 92.5 44 59 0.73
±14 ±16 ±2 ±21.4 ±18 ±14 ±0.24
II) 80 **46 **39 5.5 92.2 ***59 ***66 ***0.87
±15 ±16 ±1.8 ±17.2 ±19 ±13 ±0.22
III) 35 **58 ***25 5.9 90.8 ***30 ***43 ***0.68
±16 ±10 ±3.2 ±23 ±17 ±16 ±0.37
IV)# 4 71 119 7.3 98.7 21 34 0.58
±13 ±157 ±1.6 ±23.4 ±12 ±12 ±0.13
* p<0.05 **p<0.01; ***p<0.001; when compared to I).
# Not compared because of few patients.
Table IV. Mean specific 24 hour1311 uptake (l3,Iper unit weight ofthyroid tissue), doses of radioactivity taken up per gram of
tissue 4 hour1311 uptake and hypo- and hyperthyroidism after treatment related to the total weight ofthe thyroid gland at treatment
in patients with Graves' disease (mean standard dev.).
Weight of thyroid (grams) n 1311 uptake %/gram of tissue (24h) 131l dose uptake uCi/g 4 hour 1311 uptake, whole gland Post-treatment % hypo- thyroid % hyper- thyroid
10-19 16 3.6±1.4 135±39 36±14 80 (5)* 12
20-29 124 2.3±2.3 97±21 37±16 71 (85) 12
30-39 144 1.9±0.4 91 ±13 48±18 72 (107) 17
40-49 91 1.6±0.3 90±16 53 ±20 59 (37) 27
50-59 28 1.2±0.3 78±16 52 ±22 65 (17) 32
60-69 17 1.1 ±0.3 84±19 64±19 31 (13) 35
& 70 16 0.8±0.2 81 ±16 68±12 50 (6) 19
‘Number of patients studied for hypothyroidism.