Læknablaðið : fylgirit - 01.06.1982, Side 29

17
METABOLIC EFFECTS CAUSED BY DIURETICS AND 6-BLOCKERS
A longitadinal population study of women during 12
years
J A Sigurdsson, C Bengtsson, 0 Lindquist, M Lurie,
H Noppa, E Nyström, V Rafnsson and E Tibblin
Health Centre of Hafnarfjördur, Iceland and Sahlgren-
ska sjukhuset, University of Göteborg, Sweden
Possible metabolic side-effects were studied during
diuretic and B-blocker treatment in a population sam-
ple of women. Altogether 1462 women were studied in
1968-69, and follow-up studies of the population sam-
ple were carried out in 1974-75 and 1980-81.
During the period between 1968-69 and 1974-75, 34
women started to take diuretics and 52 6-blockers as
single antihypertensive drug. A comparison between
these women and non-hypertensive women was made con-
cerning a number of metabolic variables. Serum tri-
glycerides had decreased (p < 0.05) among those star-
ting diuretics and increased (p < 0.05) among those
starting 6-blockers when compared to intra-individual
changes of other women. No other differences of sta-
tistical significance were observed.
Out of those women who had started to take diure-
tics or 6-blockers, 18 women were still taking diure-
tics and 31 women 6-blockers as single drug when the
12-year follow-up study was carried out in 1980-81.
There seemed to be no obvious further changes of the
metabolic variables studied in those women when com-
pared to the changes observed in 1974-75.
According to our preliminary results, 34 initially
non-diabetic women had the diagnosis of diabetes bet-
ween 1968-69 and 1980-81. Hypertensives were over-
represented in this group of women, but no definite
conclusions could be made concerning the way of anti-
nypertensive treatment and the incidence of diabetes.