Læknablaðið : fylgirit - 01.06.1982, Blaðsíða 38

25
UTILIZATION OF THE ARTIFICIAL PANCREAS IN THE STUDY OF THE
POTENCY OF SEMI-SYNTHETIC HUMAN INSULIN IN TYPE I DIABETICS.
AA. PRANGE HANSEN, 0. SCHMITZ, S.E. CHRISTENSEN, H. 0RSKOV and
L. HEDING:
First and Second University Clinic of Internal Medicine, Kommu-
nehospitalet, Aarhus and NOVO Research Institute, Bagsværd, Den-
mark.
The aim of the present study was to compare the efficacy of se-
mi-synthetic human insulin (Novo) and porcine insulin in juve-
nile diabetics ^sing a glucose controlled insulin infusion sy-
stem (BiostatorK). Two types of experiments were performed.
1. Comparison of 24-hour insulin requirements: After stabiliza-
tion of the blood glucose level at 80 mg/100 ml four diabe-
tics were treated during two 24-hours periods in a randomized
succession with human or porcine insulin. The set constants
selected for the algorithms (KR = 70, KF = 67, QI = 40) mini-
mizes insulin delivery. Diurnal blood glucose levels (98.1 -
2.8 mg/100 ml and 99.0 - 2.5 mg/100 ml) and diurnal insulin
requirements (47658 - 3494 mU and 47550 - 3733 mU) were iden-
tical in the two regimens and the counter-regulatory hormones
did not differ.
2. Comparison of the glucose lowering., effect after IV glucose:
After stabilization of the blood glucose level at 80 mg/100
ml for hours six diabetics received 0.5 g glucose/kg body
weight iv over 3 min. on two separate days. Following the
glucose load human or porcine insulin were given at a con-
stant rate of 1 mU/kg body weight/min. The fall in blood glu-
cose was rectilinaar and the regression lines were superim-
posable in everv individual diabetic. The slopes (-1.15 -
J.10 and -1.16 - 0.09) and the regression coefficients (0.998
- 0.001 and 0.996 - 0.001 ) were identical in the two regimens,.
Other experiments have shown that this method is able to de-
monstrate a difference in potency of 10 per cent.
In conclusion: IV administrated semi-synthetic human and porcine
insulin have identical effects on the blood glucose in insulin-
dependent diabetics.