Læknablaðið : fylgirit - 01.06.1982, Síða 46

33
HLA-Bf AND OTHER GENETIC MARKERS IN A FAMILY WITH
THYROTOXICOSIS , ARTHRITIS , AUTOIMMUNE P.HENOMENA AND
MALIGNANCIES OF THE RETICULO-ENDOTHELIAL SYSTEM.
A. Arnasonf Ó. Jensson, G. Eyjólfsson 1), H.
Sigurðsson 1), B. Birgisdóttir and R. Fossdal.
Blood Bank, Reykjavik, Iceland, Dept. Medicine,
City Hospital, Reykjavik, Iceland 1).
The clinical findings of family members are
reported in another paper at this conference.
(Eyjólfsson et al.).
We employed 22 genetic marker systems, in-
cluding HLA, A, B, C, Bf and GLO-1- on chromosome
No. 6. At present 18 family members have been stud-
g
ied. The main risk haplotypes are: A3; B15; Bf or
c
A9; B15; Bf from one side of the family and
g
A3; B7; Bf from the other side, where increased ANF
is also observed.
Inheritance of two of these haplotypes seems
to be associated with more severe and higher fre-
quency of above mentioned diseases, and different
autoimmune antibodies. This will be compared to
similar phenomena in other Icelandic families that
have been studied.