Læknablaðið : fylgirit - 01.06.1982, Page 50

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OPTIC NEURITIS, HLA-Bf AND THREE OTHER GENETIC
MARKER SYSTEMS IN MS AND NON-MS PATIENTS
A. Þorsteinsson, A. Arnason, 0. Jensson, G. Guð-
mundsson 1), J. Benedikz 1), S. Bergmann 1) and
G. Björnsson 2).
The Blood Bank, Dept. of Neurology 1), University
Hospital, and Dept. of Ophthalmology 2), St. Josephs-
Hospital, Reykjavik, Iceland.
Genetic markers in Icelandic MS patients were
reported in 1980 (1) and an epidemiological study of
optic neuritis (ON) (2).
Covering 1966-80 a retrospective study has
been made of 38 patients with ON including 12 with-
out any other neurological signs. These have been
typed for HLA-Bf, Gc (group specific protein), MNSs
blood groups and many other genetic marker systems.
Marked differences in the frequencies of Bf
alleles is found by comparing:
1) Definite MS patients and control population
2) Definite MS patients with and without ON
3) ON MS patients with ON NON-MS patients
4) ON-NON-MS patients with control.
These results are compared with recently
published results of the same kind (3). Further in-
formation will be presented on genetic markers on
chromosome 4, Gc and MNSs, and their frequencies in
MS patients, patients with ON and control population.
(1) Árnason A. et al.: Acta Neurol. Scand.
62, Supplementum 78, p. 39 (Abstract), 1980.
(2) Bergmann S. and Viggósson G.: Abstract p. 41,
see references above. (3) Fielder A.H.L.,
Batchelor J.R. et al.: Lancet, II, 1246-1248, 1981.