Læknablaðið : fylgirit - 01.06.1982, Síða 49

36
GENETIC MARKERS AND PARKINSONISM IN ICELAND
A. Arnason, A. Þorsteinsson 1), G. Guðmundsson 1),
Ó. Jensson, I. Skaftadóttir and B. Birgisdóttir.
Blood Bank and Dept. of Neurology 1), University
Hospital, Reykjavik, Iceland.
We have information on 93 patients, who can
be divided into four main groups: A: Idiopathic
Parkinsonism (n 72); B: Parkinsonism following
encephalitis (n 6); C: Parkinsonism caused by
trauma (n 4)} D: Parkinsonism where other signs
from CNS are present before or from onset (n 11).
Group A was further subdivided: I. Patients
born after 1921, II. Patients born before 1921 but
got their Parkinsonism before the age of 60,
III. Patients born before 1921 and got their Park-
insonism after the age of 60 years.
Twenty one genetic marker systems were em-
ployed: Blood groups, Bf, C3, Gc, Hp., Tf., AcP.,
GPT, GLO-1, EsD, El, E2 and HLA.
Duffy blood group„ and C3 demonstrated deviat-
ion from the control, C3* beeing increased in group
AIII. The following antigens had higher frequency
in Parkinsonism: A2, A3, B5, B15 and B37. All
other systems showed no association with the disease.
The genetic marker association will be
further discussed.