Læknablaðið : fylgirit - 01.06.1982, Side 59

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CIMETIDINE AND NAPROSYN: NO INTERACTION
Dunqal H., Kjeld M., Kristjansson F., Þjoðleifsson B.
Landspitalinn - Medical Dep. - Reykjavik
Introduction: Cimetidine has been reported to increase or
prolong the action of several drugs when given simultaneously.
This interaction is probably due to cimetidine's action on
hepatic microsomal enzymes and on hepatic blood flow.
Cimetidine and naprosyn are sometimes given together and it
was therefore of interest to explore a possible interaction.
Material and Methods: Ten healthy individuals participated
in the study which had a crossover design. First, an oral
dose of 500 mg Naprosyn was given and blood samples taken at
a given time from 0 to 48 hrs. Two weeks later the same
procedure was repeated but cimetidine ( 1000 mg/day ) was
given 2 days prior to the test and on the test day. The
following parameters were calculated and compared by a paired
t test: Mean serum concentration, half life, area under the
concentration curve and time to the p.feak concentration.
Results: No difference of statistical significance was found.
There was a trend towards a faster absorption with cimetidine.
Conclusion: There seems to be no interaction of clinical
significance between cimetidine and naprosyn.