Læknablaðið - 15.10.1982, Blaðsíða 29
LÆKNABLADID
241
hefur veriö skrifað um þetta efni (4, 5, 6), en
litlar heimildir eru um samanburð á aukaverk-
unum Metrizamid annars vegar og skugga-
gjafa með deyfandi lyfi hins vegar. í>að liggur
ekki ljóst fyrir, hvort hinn mikli verðmunur
þessara tveggja aðferða skili sér að fullu í
minni tíðni aukaverkana hjá Metrizamid. (15).
Af hagkvæmnisástæðum hafa Angiografin
og Lidocain nokkra kosti fram yfir Metriza-
mid. Hvorttveggja eru upplausnir tilbúnar til
notkunar, en Metrizamid fæst ennþá eingöngu
sem þurrfrosið duft í hettuglösum. Til þess að
ná tilætluðu magni og styrkleika verður að
leysa innihaldið úr 4 hettuglösum upp í ákveðnu
magni af saltvatni og tekur það sinn tíma.
Síðan þarf að draga hverja tilbúna upplausn
fyrir sig upp í þrýstisprautuna.
Innspýting á Angiografin með Lidocain 2 %
býður upp á hagkvæma, áreiðanlega, örugga,
ódýra og fyrir sjúklingana óþægindalitla rann-
sókn á útlimaæðum.
Greinarhöfundur þakkar starfsfólkinu á Lab 1, Röntgen-
deild Landspítalans fyrir auðsýndan áhuga og aðstoð við
framkvæmd könnunarinnar.
SUMMARY
In a crossover study of 28 patients referred for
peripheral arteriography of the lower extremities
the side effects of Metrizamid and a conventional
contrast medium Angiografin with Lidocain was
compared. Of 12 patients who were administered
Angiografin with Lidocain 1 %, 2 patients complain-
ed of severe heat and two made involuntary
movements of pain whereas no patient was visibly
distressed after the administration of Metrizamid.
Statistically a difference in favour of Metrizamid (P:
0.047). In a second group of 16 patients who
received Lidocain 2 % with the Angiografin, only
one patient showed obvious signs of pain but none
of those who got Metrizamid (P: 0.5).
Only 3 patients in both groups experienced
severe side-effects after the administration of Angi-
ografin with Lidocain. All three patients had occlusi-
on of at least one main artery and extensive
collateral circulation.
Taking into consideration the much higher price
of Metrizamid, the Angiografin-Lidocain 2 % com-
bination is to be preferred.
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