Læknablaðið : fylgirit - 01.05.1978, Blaðsíða 74

Vi
Clearence (ke’Vi)
.17-
.16-
.15-
.14-
.13-
.12-
.11-
.10-
.09-
.08-
.07-
.06-
l-kg'1
-0.095
.18-
.17-
.16
.15
.14
.13
.12-
.11-
.10-
.09
l»kg-1> hr'1
0.110
-0.158
-0.119
-i-------------- -------------------------------------------------1--------------------------------------------------------------------------r
0 500 mg • 2 1000mg- 2 0 500 mg ■ 2 lOOOmg > 2
mean i SE : 0.10310.011 0.13210.008 0.118 1 0.011 mean l SE : 0.117 10.006 0.155 1 0.007 0.121 10.008
t-test : p<0.05 NS t-test : p <0.001 NS
Wilcoxon : NS NS Wilcoxon : p<0.02 NS
ANOVAR : NS ANOVAR : p<0.01
Friedman : Figu re 6 . NS Friedman : Figure 8. p< 0.025
mean í SE : 3.273Í0.265 2.429i0.129 3.01710.181
t - test :
Wilcoxon :
ANOVAR :
Friedman :
p <0.02 NS
p<0.02 NS
p<0.01
p< 0.025
R eferenc es:
1) Z. E. Mielens, H.P. Drobeck, J. Rozitis,
Jr. & V.R. Sansone, Jr. : Interaction of
aspirin with nonsteroidal anti-inflammatory
drugs in rats. J. Pharm. Pharmac.
1968, 20, 567.
2) C.G. Van Arman, G.W. Nuss & E.A.
Risley: Interactions of aspirin, indomethacin
and other drugs in adjuvantinduced arthritis
in the rat. J. Pharmacol. Exp.Ther.
1973, 187, 400.
3) R. Jeremy & J. Towson: Interaction between
aspirin and indomethacin in the treatment of
rheumatoid arthritis. Med. J. Aust.
1970, 2, 127.
4) G.D. Champion, H.E. Paulus, E. Mongan,
R. Okun, C.M. Pearson & E. Sarkissian:
The effect of aspirin on serum indomethacin.
Clin. Pharmacol. Ther. 1972, 13,
239.
5) A. Rubin, B.E. Rodda, P. Warrick, C.M.
Gruber, Jr. & A.S. Ridolfo: Interactions of
aspirin with nonsteroidal anti-lnflammatory
F i g u r e 7 .
72