Læknablaðið : fylgirit - 01.05.1978, Blaðsíða 85

TABLE II.
Assessment of therapeutic result wtth
90
Y. A comparifaon
with controi knee.
Month Traataent No. of No. of Significonc. of
improved unchonged X 2 imp rov.ment
3 90 v 21 2
ControX 2 21 28.17 P<0.001
6 90 v 18 5
T • Control 2 21 19.90 P< 0.001
12 90 v 13 9
Y, Control 3 19 7.96 ; P<0.01
24 90 v 11 9
Control 5 15 2.61 0.1<P
42 90 v 10 9
Y. Control 5 14 1.76 0.1<P
Significance of improvement bv X technic, comparing proportions
of unchanged and improved 9®Y-treated knees and controls.
Figure 3. Comparison of radiological
deterioration between 9®Y-treated and control
knee-joint.
Fia. 4
Figure 4. Correlation between clinical
diagnosis and therapy result.
One patient treated with 90Y resin colloid
developed reactions (lasting for 24 hours)
consisting of shivering, pyrexia, and general
malaise. In 2 of the patients given 90Y silicate
articular pain and exacerbation of effusion
occurred.
Discussion:
The probability of spontaneous remission was
small in the selected patient group with iong-
standing therapy resistant gonitis. The compari-
son of 90Y with Depomedrone(^) alone provided
evidence of the good therapeutic effect of 90Y.
The effect of intra-articularly injected radio-
nuclides was significantly better than that for
the controls at 3, 6, and 12 months and weakened
in proportion to the length of the follow-up period.
At the last check-up the results for the 90Y
treated knees were still better than those for the
controls but the difference was not significant.
Correct selection of patients for 90Y therapy
is of great importance.
1. Patients with severe articular destruction,
dislocation, and instability are likely to fail
to respond to this form of therapy.
2. Patients with genc-rai high disease activity
should primarily be given systemic therapy.
3. Patients in fertiie age should receive other
forms of local therapy (2). Side-effects
occurred rarely and were mild. The method
83