Læknablaðið : fylgirit - 01.05.1978, Blaðsíða 86
is inexpensive, simple to carry out and
causes no discomfort to the patient.
Abstract:
The results are reported of the treatment of
33 patients with long-standing, therapy resistant
synovitis and effusion of the knee by intra-
articular injection of 90Yttrium. In 25 patients
with bilateral gonitis the effect of the treatment
was compared with the effect of local cortico-
steroid therapy to the other knee. The irradiated
group showed statistically significantiy better
therapeutic results at 3, 6 and 12 months and
the effect weakened in proportion to the length
of the follow-up period. At the last check-up
at 3.5 years, 52% of this group showed improve-
R eferences:
1. Bridgman, J.F., Bruckner, F., Bieehen,
N. M.: Radioactive yttrium in the treatment
of rheumatoid knee effusions. Ann rheum
Dis 30: 180, 1971.
2. de la Chapelle, A., Oka. M. , Rekonen,
A. , Ruotsi, A.: Chromosome damage after
intra-articular injections of radioactive
yttrium. Ann rheum Dis 31: 508, 1972.
3. Chausse, D.J. : L'introduction intra-articu-
laire de corps radio-actifs en pathologie du
genou. 19' Semaine de Rhumatologie d-Aix-
les-Bains, avril, 1970.
4. Delbarre, F., Cayla, J. , Roucayrol, J.-C.,
Aignan, M. , Ingrand, J.: Synoviorthéses
(synoviothérapie par les radioisotopes). Etude
de plus de 400 traitements et perspectives
d’avenir. Ann méd interne, avril, 1970.
121, no 4 pp 441-445.
5. Gumpel, J.M. , Williams, E.D., Glass, H.I.:
Use of yttrium 90 in persistent synovitis of
the knee. I. Ann rheum Dis 32: 223-227,
1973.
6. Gumpel, J.M. , Farran, H.E.A., Williams,
E.D.: IJse of yttrium 90 in persistent
synovitis of the knee. II. Ann rheum Dis
33: 126, 1974.
7. Gumpel, J.M. , Roles, N C.: A controlled
trial of intra-articular radiocolloids versus
surgical synovectomy in persister.t synovitis.
Lancet, March 1, 1975.
8. Gumpel, J.M. , Crawlej', J.C.W.: A single-
ment as against 26% of the controls. The differ-
ence in radiological deterioration at the end of
the observation period between the two groups
was not significant. Local remission in the
treated joint in spite of high general clinical
activity was recorded in 7 patients. In 4 patients,
in whom the results were unsatisfactory, severe
articular destruction and instability were noted
before therapy. Assessment of the correlation
between clinical diagnosis and therapeutic results
shows that the treatment seems to be most
successful in patients with rheumatoid arthritis
and unsatisfactory in patients with psoriatic
arthritis. General reactions were observed in
one, and local reactions in two patients. Irradia-
tion therapy seems to be the treatment of choice
in patients over 40, with long-standing knee
arthritis of rheumatic origin.
centre comparison of four radio-colloids of
yttrium 90 in clinical use. Brit J Radiology
5: 377-381, 1975.
9. Isomáki, A.M. , Inoue, H. , Oka, M.:
Uptake of resin colloid by synovial fluid
cells and synovial membrane in rheumatoid
arthritis. Scand J Rheum 1: 53-60, 1972.
10. Lansbury, J.: Methods for Evaluating
Rheumatoid Arthritis. In Arthritis and
Allied Conditions (ed. J. Hollander),
p. 282-287, Lea & Febiger, Philadelpia, 1972.
11. Muller, W. , Pavelka, K. , Fridrich, R.:
Treatment of chronic articular effusions with
90-Yttrium (90Y). Scand J Rheum 4: 216-
220, 1975.
12. Oka, M. , Rekonen, A. , Ruotsi, A., Seppala,
O.: Intra-articular injection of Y-90 resin
colloid in the treatment of rheumatoid knee
joint effusion. Acta Rheum Scand 17: 148-
160, 1971.
13. Oka, M.: Radioation Synovectomy of the
Rheumatoid knee with Yttrium 90. Annals
Clin Research 7: 205-210, 1975.
14. Rebut-Bonneton, C. , Roucayrol, J.C.,
Delbarre, F.: Effect of intra-articular
injection of radioactive colloids of erbium
and yttrium on the growth of rabbit legs.
Ann Rheum Dis 34: 529-533, 1975.
15. Szanto, E., Gullberg, R.; Radioactive
yttrium (90Y) in the treatment of chronic
knee-joint synovitis. Scand J Rheum 2: 7,
1972.
84