Læknablaðið : fylgirit - 01.05.1978, Page 86

Læknablaðið : fylgirit - 01.05.1978, Page 86
is inexpensive, simple to carry out and causes no discomfort to the patient. Abstract: The results are reported of the treatment of 33 patients with long-standing, therapy resistant synovitis and effusion of the knee by intra- articular injection of 90Yttrium. In 25 patients with bilateral gonitis the effect of the treatment was compared with the effect of local cortico- steroid therapy to the other knee. The irradiated group showed statistically significantiy better therapeutic results at 3, 6 and 12 months and the effect weakened in proportion to the length of the follow-up period. At the last check-up at 3.5 years, 52% of this group showed improve- R eferences: 1. Bridgman, J.F., Bruckner, F., Bieehen, N. M.: Radioactive yttrium in the treatment of rheumatoid knee effusions. Ann rheum Dis 30: 180, 1971. 2. de la Chapelle, A., Oka. M. , Rekonen, A. , Ruotsi, A.: Chromosome damage after intra-articular injections of radioactive yttrium. Ann rheum Dis 31: 508, 1972. 3. Chausse, D.J. : L'introduction intra-articu- laire de corps radio-actifs en pathologie du genou. 19' Semaine de Rhumatologie d-Aix- les-Bains, avril, 1970. 4. Delbarre, F., Cayla, J. , Roucayrol, J.-C., Aignan, M. , Ingrand, J.: Synoviorthéses (synoviothérapie par les radioisotopes). Etude de plus de 400 traitements et perspectives d’avenir. Ann méd interne, avril, 1970. 121, no 4 pp 441-445. 5. Gumpel, J.M. , Williams, E.D., Glass, H.I.: Use of yttrium 90 in persistent synovitis of the knee. I. Ann rheum Dis 32: 223-227, 1973. 6. Gumpel, J.M. , Farran, H.E.A., Williams, E.D.: IJse of yttrium 90 in persistent synovitis of the knee. II. Ann rheum Dis 33: 126, 1974. 7. Gumpel, J.M. , Roles, N C.: A controlled trial of intra-articular radiocolloids versus surgical synovectomy in persister.t synovitis. Lancet, March 1, 1975. 8. Gumpel, J.M. , Crawlej', J.C.W.: A single- ment as against 26% of the controls. The differ- ence in radiological deterioration at the end of the observation period between the two groups was not significant. Local remission in the treated joint in spite of high general clinical activity was recorded in 7 patients. In 4 patients, in whom the results were unsatisfactory, severe articular destruction and instability were noted before therapy. Assessment of the correlation between clinical diagnosis and therapeutic results shows that the treatment seems to be most successful in patients with rheumatoid arthritis and unsatisfactory in patients with psoriatic arthritis. General reactions were observed in one, and local reactions in two patients. Irradia- tion therapy seems to be the treatment of choice in patients over 40, with long-standing knee arthritis of rheumatic origin. centre comparison of four radio-colloids of yttrium 90 in clinical use. Brit J Radiology 5: 377-381, 1975. 9. Isomáki, A.M. , Inoue, H. , Oka, M.: Uptake of resin colloid by synovial fluid cells and synovial membrane in rheumatoid arthritis. Scand J Rheum 1: 53-60, 1972. 10. Lansbury, J.: Methods for Evaluating Rheumatoid Arthritis. In Arthritis and Allied Conditions (ed. J. Hollander), p. 282-287, Lea & Febiger, Philadelpia, 1972. 11. Muller, W. , Pavelka, K. , Fridrich, R.: Treatment of chronic articular effusions with 90-Yttrium (90Y). Scand J Rheum 4: 216- 220, 1975. 12. Oka, M. , Rekonen, A. , Ruotsi, A., Seppala, O.: Intra-articular injection of Y-90 resin colloid in the treatment of rheumatoid knee joint effusion. Acta Rheum Scand 17: 148- 160, 1971. 13. Oka, M.: Radioation Synovectomy of the Rheumatoid knee with Yttrium 90. Annals Clin Research 7: 205-210, 1975. 14. Rebut-Bonneton, C. , Roucayrol, J.C., Delbarre, F.: Effect of intra-articular injection of radioactive colloids of erbium and yttrium on the growth of rabbit legs. Ann Rheum Dis 34: 529-533, 1975. 15. Szanto, E., Gullberg, R.; Radioactive yttrium (90Y) in the treatment of chronic knee-joint synovitis. Scand J Rheum 2: 7, 1972. 84
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