Læknablaðið : fylgirit - 01.08.2003, Blaðsíða 62

I POSTERS / 27TH NORDIC PSYCHIATRIC CONGRESS
P - 11 Thursday 15/8, 14:00-15:00
Functional brain imaging in bulimia nervosa: Preliminary
data
Van den Eynde F, MD, Department of Psychiatry, Ghent University, 9000 Ghent,
Belgium. Naudts KH, De Saedeleer S, Vervaet M, Audenaert K, Maenhout A,
Dierckx R, Ven Heeri.
Frederique. Vandeneynde@UGent. be
Background: Previous research has provided substantial support of
involvement of dysfunction of brain circuitry in both pathogenesis
and pathophysiology of BN.
BN-P (purging) and BN-NP (non-purging) are 2 subtypes of BN.
Aims: In this study we aimed at further exploring the brain
perfusion patterns related to potential functional disturbances in
the brain circuits in patients with BN-P.
Methods: A 99m-Tc-ethyl cysteine dimer (ECD) SPECT was ac-
quired in 7 female BN-P inpatients (mean age 23.8 y, mean BMI
20,3). Seven healthy female volunteers (mean age 25.4 y) were used
as a control group. AII subjects showed a normal CT-scan of the
brain. Group comparisons were performed using SPM 99.
Results: Compared to the group of healthy volunteers, the BN-P
patients showed significant hyperperfusion in the right parieto-
occipital lobe, the right frontal lobe, the anterior and posterior
cingulate (limbic) cortex and to a lesser extent the left temporal
lobe. No significant brain hypoperfusions were found within this
group comparison.
Condusion: These preliminary data in BN-P inpatients demon-
strated hyperfusions in both cortical and limbic structures. The
increased perfusion in both limbic and cortical lobes suggest an
important role of dysfunctional pathways in brain circuitry com-
prising limbic, cortical and subcortical structures, in BN-P.
P -12 Thursday 14/8,14:00-15:00
Eating disorders at Landspítali University Hospital,
Reykjavik, 1983-2001
GiiiMuuk Þorsteinsdóttir, Psychiatrist, Department of Psychiatry, Landspítali Uni-
versity Hospital, Reykjavík, Iceland
gudlthor@landspitali.is
Objective: To investigate the number, demographics, and survival
of patients in first admission to psychiatric inpatient treatment at
Landspitalinn University Hospital, Reykjavik, with a diagnosis of
an eating disorder. Tlie study includes admissions to the child and
adolescent unit and about 90% of all emergency psychiatric hospi-
tal beds in Iceland.
Method: Medical records of hospitalised patients with a discharge
diagnosis of an eating disorder according to ICD-9 and ICD-10 in
the period of 1.1.1983- 31.12.2001, were viewed. Survival of the
patients was investigated at the end of the study period.
Results: A total of 110 patients received a diagnosis, 103 women and
7 men. Mean age of the women was 23,5 years (8-50 years). Fifty-
two (51.5%) women had anorexia nervosa, 40 (38.8%) had bulimia
nervosa, 2 had atypical bulimia nervosa and 9 (8,7%) had EDNOS
diagnosis. Of the men, 2 had anorexia, 2 atypical anorexia and 3
bulimia nervosa. Mean age was 27,5 years, (13-62 years). Forty-five
(43.7%) women were diagnosed in the last 5 years (1997-2001) of
the study period and 6 (86%) men. At the end of study period, 2
women had died, 98% of patients were alive.
Conclusions: Number of diagnoses dramatically increased over time.
This may be due to either increased incidence of eating disorders or
to a better diagnosis. 6,4% of the sample were men, which is as ex-
pected. Low mortality rate may be explained by the fact that the
majority of patients were diagnosed in the latter half of the period.
P - 13 Thursday 14/8,14:00-15:00
Treatment of bulimia nervosa with sertraline: A
randomized controlled trial
Capasso Anna, PhD, University of Salerno, Via Ponte don Melillo-Fischiano-
Salerno, Italia. - Sabatino C, Milano W, Petrella C.
annacap@unisa.it
Bulimia Nervosa (BN) is one of the most frequent eating disorders
in industrialized societies. Reduced serotonin activity has been
suggested to trigger some of the cognitive and mood disturbances
associated with BN. Therefore, pharmacological treatment of BN is
mainly based on the use of selective serotonin reuptake inhibitors,
that have proved effective. At the present, the biological bases of
this disorder are not yet completely clear.
The aim of this randomized, controlled trial was to verify the
efficacy of sertraline, a selective serotonin reuptake inhibitor, in a
group of patients with a diagnosis of BN. Twenty female out-
patients, with an age range of 24-36 years and diagnosis of BN-
binge purging, as defined by the DSM IV, were assigned randomly
to two treatment groups: the first group received 100 mg/day sertra-
line for 12 weeks, the second group received placebo. The study was
conducted for 12 weeks with weekly clinical assessments.
At the end of the observation period, in the group treated with
sertraline there was a statistical significant reduction in the number
of binge eating crisis and purging with respect to the group who
received placebo treatment. In no case was treatment interrupted
for emergency effects.
This study confirms that sertraline is well tolerated and effective
in reducing binge-eating crises and purging in patients with bulimia
nervosa.
P - 14 Thursday 14/8,14:00-15:00
Treatment of monosymptomatic sleep disturbances
during premenstrual period with zolpidem
Judil Kadic.s. MD, Dr., Senior Psychiatrist, 2nd Department of Psychiatry, Aladar
Petz Teaching Hospital, Gyor, Hungary. Gyorgy Ostorharics-Horvath, MD, PhD.
radicsjudit@freemail.hu
Cyclic changes of gonadal steroid hormones play a role in the regu-
lation of mood and affect. Progesterone has been shown to have
major influence on thermoregulation and sleep. High levels of pro-
gesterone during the luteal phase have been associated with sleep
disturbances during the premenstrual period. It has been described
thal premenstrual syndrome may only appear in the form of sleep
disturbances without other significant complaints (recurrent luteal
phase insomnia) in 31% of reproductive age females.
62 LæKNABLAÐIÐ / FYLGIRIT 48 2003/89