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Læknablaðið - 01.04.2017, Blaðsíða 23

Læknablaðið - 01.04.2017, Blaðsíða 23
LÆKNAblaðið 2017/103 183 R A N N S Ó K N Heimildir 1. Rakić M, Patrlj L, Kopljar M, Kliček R, Kolovrat M, Loncar B, Busic Z. Gallbladder cancer, review article. Hepatobiliary Surg Nutr 2014; 3: 221-6. 2. Jónasson JG, Tryggvadóttir L. Krabbamein á Íslandi. Krabbameinsfélag Íslands, Reykjavík 2008; 42-3. 3. Panebianco A, Volpi A, Lozito C, Prestera A, Ialongo P, Palasciano N. Incidental gallbladder carcinoma: our experience. G Chir 2013; 34: 167-9. 4. Fujii H, Aotake T, Horiuchi T, Chiba Y, Imamura Y, Tanaka K. Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature. Hepatogastroenterology 2001; 48: 1588-93. 5. Kai K, Aishima S, Miyazaki K. Gallbladder cancer: Clinical and pathological approach. World J Clin Cases 2014; 2: 515-21. 6. Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima A, Kondo N, et al. Prognostic factors of patients with advanced gallbladder carcinoma following aggressive surgical resection. J Gastrointest Surg 2011; 15: 1007-16. 7. Goetze TO. Gallbladder carcinoma: Prognostic factors and therapeutic options. World J Gastroenterol 2015; 21: 12211- 7. 8. Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clin Epidemiol 2014; 6: 99-109. 9. Lazcano-Ponce EC, Miquel JF, Munoz N, Herrero R, Ferrecio C, Wistuba I et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin 2001; 51: 349-64. 10. Wang Y-F, Feng F-L, Zhao Z-H, Ye Z-X, Zeng H-P, Li Z et al. Combined detection tumor markers for diagnosis and prognosis of gallbladdercancer. World J Gastroenterol 2014; 20: 4085-92. 11. Ioannidis O, Paraskevas G, Varnalidis I, Ntoumpara M, Tsigkriki L, Gatzos S et al. Primary gallbladder cancer discovered postoperatively after elective and emergency cholecystectomy. Klin Onkol 2013; 26: 31-4. 12. Choi S-B, Han H-J, Kim C-Y, Kim W-B, Song T-J, Suh S-O et al. Incidental gallbladder cancer diagnosed following laparoscopic cholecystectomy. World J Surg 2009; 33: 2657- 63. 13. Lai C-H-E, Lau W-Y. Gallbladder cancer – a comprehensi- ve review. Surgeon 2008; 2: 101-10. 14. Weinstein D, Herbert M, Bendet N, Sandbank J, Halevy A. Incidental finding of gallbladder carcinoma. Isr Med Assoc J 2002; 4: 334-6. 15. Romano F, Franciosi C, Caprotti R, De Fina S, Porta G, Visintini G, et al. Laparoscopic cholecystectomy and unsuspected gallbladder cancer. Eur J Surg Oncol 2001; 27: 225-8. 16. Varshney S, Butturini G, Gupta R. Incidental carcinoma of the gallbladder. Eur J Surg Oncol 2002; 28: 4-10. 17. Mekeel KL, Hemming AW. Surgical management of gall- bladder carcinoma: a review. J Gastrointest Surg 2007; 11: 1188-93. 18. Kanthan R, Senger J-L, Ahmed S, Kanthan SC. Gallbladder cancer in th 21st century. J Oncol 2015; 2015: 967472. 19. Furlan A, Ferris JV, Hosseinzadeh K, Borhani AA. Gallbladder carcinoma update: multimodality imaging evaluation, staging, and treatment options. AJR Am J Roentgenol 2008; 191: 1440-7. 20. Benson AB, Abrams TA, Ben-Josef E, Bloomston M, Botha JF, Clary BM, et al. Hepatobiliary cancers: clinical practice guidelines in oncology. J Natl Compr Canc Netw 2009; 7: 350-91. 21. Andrén-Sandberg Å. Diagnosis and management of gall- bladder cancer. N Am J Med Sci 2012; 4: 293-9. 22. Berger-Richardson D, Chesney TR, Englesakis M, Govindarajan A, Cleary SP, Swallow CJ. Trends in port- -site metastasis after laparoscopic resection of incidental gallbladder cancer: A systematic review. Surgery 2017: 161: 618-27. 23. Shirobe T, Maruyama S. Laparoscopic radical cholecystect- omy with lymph node dissection for gallbladder carcin- oma. Surgical Endosc 2015; 29: 2244-50. 24. Cavallaro A, Piccolo G, Panebianco V, Lo Menzo E, Berretta M, Zanghi A, et al. Incidental gallbladder cancer during laparoscopic cholecystectomy: Managing an unex- pected finding. World J Gastroenterol 2012; 18: 4019-402. 25. Cho J-Y, Han H-S, Yoon Y-S, Ahn K-S, Kim Y-H, Lee K-H. Laparoscopic approach for suspected early-stage gall- bladder carcinoma. Arch Surg 2010; 75: 128-33. 26. Lundberg O, Kristoffersson A. Open versus laparoscopic cholecystectomy for gallbladder carcinoma. J Hepatobiliary Pancreat Surg 2001; 8: 525-9. 27. Juliusson G, Jonasson JG, Jonsdottir SB, Garcia HG, Olafsdottir E, Möller PH, Björnsson ES. Biliary tract malign- ancies: a population-based study on incidence, prognosis and management of patients. Scand J Gastoenterol 2016: 51: 1520-5. 28. Lee SE, Kim KS, Kim WB, Kim I-G, Nah YW, Ryu DH et al. Practical guidelines for the surgical treatment of gallbladd- er cancer. J Korean Med Sci 2014; 29: 1333-40. 29. Castillo OA, Vitagliano G. Port site metastasis and tumor seeding in oncologic laparoscopic urology. Urology 2008: 71: 372-8. ENGLISH SUMMARY Introduction: Gallbladder carcinoma is about 0.5% of all cancer. The outcome of patients with gallbladder carcinoma is overall bad and the only potentially curative treatment is surgery. The aim of this study was to determine the disease’s prevalence in Iceland and outcome of the patients diagnosed in the study period. Patients and methods: This was a retrospective study of all diagnosed patients with gallbladder carcinoma during the years 2004-2013. A list of patients was obtained from the Icelandic Cancer Registry. Information was gathered from the patient’s charts in Landspitali University Hospital and the Hospital in Akureyri. Descriptive statistics was used to analyze the results. Median follow-up time was 6 years. Results: Twenty-four patients were diagnosed with gallbladder carci- noma in Iceland during the study period, 16 women and 8 men. Eighteen patients were diagnosed in Landspitali and six in the Hospital in Akur- eyri. The average age at diagnosis was 73 years. Eighteen patients have died, on average 5 months after the time of diagnosis. Adenocarcinoma was the most common cancer type (n=19). Three patients (3/24, 12.5%) underwent extended operation following the diagnosis of the gallbladder carcinoma. Nine patients (9/24, 37.5%) had advanced disease at the time of diagnosis and died within two months after being diagnosed with gall- bladder carcinoma. Conclusion: Gallbladder carcinoma is a rare cancer type in Iceland and has a bad prognosis. One third of the patients had no connection with Landspitali University Hospital following the diagnosis. Extended sur- gery following the diagnosis was seldom performed. Gallbladder carcinoma in Iceland 2004-2013 Bryndís Baldvinsdóttir1, Haraldur Hauksson2, Kristín Huld Haraldsdóttir1 1Department of Surgery, Landspitali University Hospital, 2Department of Surgery, Akureyri Hospital. Key words: gallbladder carcinoma, gastrointestinal cancer, adenocarcinoma, extended cholecystectomy. Correspondence: Kristín Huld Haraldsdóttir, kristinh@landspitali.is að meðferð sjúklinga sé á fárra höndum og að þeir séu ræddir á samráðsfundum sem eru mikilvægur vettvangur þar sem margar sérgreinar koma að og geta gefið ráðleggingar varðandi meðferð. Einnig er mikilvægt að hefja framskyggna skráningu í gagna- grunn yfir alla einstaklinga sem greinast með gallblöðrukrabba- mein á Íslandi, þar sem skráðar yrðu upplýsingar um greiningu og meðferð. Með þeim hætti fáum við mælikvarða sem hjálpar okkur að meta hvernig meðferð hérlendis er háttað miðað við þau lönd sem við berum okkur saman við.

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