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R A N N S Ó K N
Heimildir
1. Rakić M, Patrlj L, Kopljar M, Kliček R, Kolovrat M,
Loncar B, Busic Z. Gallbladder cancer, review article.
Hepatobiliary Surg Nutr 2014; 3: 221-6.
2. Jónasson JG, Tryggvadóttir L. Krabbamein á Íslandi.
Krabbameinsfélag Íslands, Reykjavík 2008; 42-3.
3. Panebianco A, Volpi A, Lozito C, Prestera A, Ialongo P,
Palasciano N. Incidental gallbladder carcinoma: our
experience. G Chir 2013; 34: 167-9.
4. Fujii H, Aotake T, Horiuchi T, Chiba Y, Imamura Y,
Tanaka K. Small cell carcinoma of the gallbladder: a
case report and review of 53 cases in the literature.
Hepatogastroenterology 2001; 48: 1588-93.
5. Kai K, Aishima S, Miyazaki K. Gallbladder cancer: Clinical
and pathological approach. World J Clin Cases 2014; 2:
515-21.
6. Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima
A, Kondo N, et al. Prognostic factors of patients with
advanced gallbladder carcinoma following aggressive
surgical resection. J Gastrointest Surg 2011; 15: 1007-16.
7. Goetze TO. Gallbladder carcinoma: Prognostic factors and
therapeutic options. World J Gastroenterol 2015; 21: 12211-
7.
8. Hundal R, Shaffer EA. Gallbladder cancer: epidemiology
and outcome. Clin Epidemiol 2014; 6: 99-109.
9. Lazcano-Ponce EC, Miquel JF, Munoz N, Herrero R,
Ferrecio C, Wistuba I et al. Epidemiology and molecular
pathology of gallbladder cancer. CA Cancer J Clin 2001; 51:
349-64.
10. Wang Y-F, Feng F-L, Zhao Z-H, Ye Z-X, Zeng H-P, Li Z et
al. Combined detection tumor markers for diagnosis and
prognosis of gallbladdercancer. World J Gastroenterol
2014; 20: 4085-92.
11. Ioannidis O, Paraskevas G, Varnalidis I, Ntoumpara M,
Tsigkriki L, Gatzos S et al. Primary gallbladder cancer
discovered postoperatively after elective and emergency
cholecystectomy. Klin Onkol 2013; 26: 31-4.
12. Choi S-B, Han H-J, Kim C-Y, Kim W-B, Song T-J, Suh S-O
et al. Incidental gallbladder cancer diagnosed following
laparoscopic cholecystectomy. World J Surg 2009; 33: 2657-
63.
13. Lai C-H-E, Lau W-Y. Gallbladder cancer – a comprehensi-
ve review. Surgeon 2008; 2: 101-10.
14. Weinstein D, Herbert M, Bendet N, Sandbank J, Halevy A.
Incidental finding of gallbladder carcinoma. Isr Med Assoc
J 2002; 4: 334-6.
15. Romano F, Franciosi C, Caprotti R, De Fina S, Porta G,
Visintini G, et al. Laparoscopic cholecystectomy and
unsuspected gallbladder cancer. Eur J Surg Oncol 2001; 27:
225-8.
16. Varshney S, Butturini G, Gupta R. Incidental carcinoma of
the gallbladder. Eur J Surg Oncol 2002; 28: 4-10.
17. Mekeel KL, Hemming AW. Surgical management of gall-
bladder carcinoma: a review. J Gastrointest Surg 2007; 11:
1188-93.
18. Kanthan R, Senger J-L, Ahmed S, Kanthan SC. Gallbladder
cancer in th 21st century. J Oncol 2015; 2015: 967472.
19. Furlan A, Ferris JV, Hosseinzadeh K, Borhani AA.
Gallbladder carcinoma update: multimodality imaging
evaluation, staging, and treatment options. AJR Am J
Roentgenol 2008; 191: 1440-7.
20. Benson AB, Abrams TA, Ben-Josef E, Bloomston M, Botha
JF, Clary BM, et al. Hepatobiliary cancers: clinical practice
guidelines in oncology. J Natl Compr Canc Netw 2009; 7:
350-91.
21. Andrén-Sandberg Å. Diagnosis and management of gall-
bladder cancer. N Am J Med Sci 2012; 4: 293-9.
22. Berger-Richardson D, Chesney TR, Englesakis M,
Govindarajan A, Cleary SP, Swallow CJ. Trends in port-
-site metastasis after laparoscopic resection of incidental
gallbladder cancer: A systematic review. Surgery 2017: 161:
618-27.
23. Shirobe T, Maruyama S. Laparoscopic radical cholecystect-
omy with lymph node dissection for gallbladder carcin-
oma. Surgical Endosc 2015; 29: 2244-50.
24. Cavallaro A, Piccolo G, Panebianco V, Lo Menzo E,
Berretta M, Zanghi A, et al. Incidental gallbladder cancer
during laparoscopic cholecystectomy: Managing an unex-
pected finding. World J Gastroenterol 2012; 18: 4019-402.
25. Cho J-Y, Han H-S, Yoon Y-S, Ahn K-S, Kim Y-H, Lee K-H.
Laparoscopic approach for suspected early-stage gall-
bladder carcinoma. Arch Surg 2010; 75: 128-33.
26. Lundberg O, Kristoffersson A. Open versus laparoscopic
cholecystectomy for gallbladder carcinoma. J Hepatobiliary
Pancreat Surg 2001; 8: 525-9.
27. Juliusson G, Jonasson JG, Jonsdottir SB, Garcia HG,
Olafsdottir E, Möller PH, Björnsson ES. Biliary tract malign-
ancies: a population-based study on incidence, prognosis
and management of patients. Scand J Gastoenterol 2016:
51: 1520-5.
28. Lee SE, Kim KS, Kim WB, Kim I-G, Nah YW, Ryu DH et al.
Practical guidelines for the surgical treatment of gallbladd-
er cancer. J Korean Med Sci 2014; 29: 1333-40.
29. Castillo OA, Vitagliano G. Port site metastasis and tumor
seeding in oncologic laparoscopic urology. Urology 2008:
71: 372-8.
ENGLISH SUMMARY
Introduction: Gallbladder carcinoma is about 0.5% of all cancer. The
outcome of patients with gallbladder carcinoma is overall bad and the
only potentially curative treatment is surgery. The aim of this study was
to determine the disease’s prevalence in Iceland and outcome of the
patients diagnosed in the study period.
Patients and methods: This was a retrospective study of all diagnosed
patients with gallbladder carcinoma during the years 2004-2013. A list of
patients was obtained from the Icelandic Cancer Registry. Information
was gathered from the patient’s charts in Landspitali University Hospital
and the Hospital in Akureyri. Descriptive statistics was used to analyze
the results. Median follow-up time was 6 years.
Results: Twenty-four patients were diagnosed with gallbladder carci-
noma in Iceland during the study period, 16 women and 8 men. Eighteen
patients were diagnosed in Landspitali and six in the Hospital in Akur-
eyri. The average age at diagnosis was 73 years. Eighteen patients have
died, on average 5 months after the time of diagnosis. Adenocarcinoma
was the most common cancer type (n=19). Three patients (3/24, 12.5%)
underwent extended operation following the diagnosis of the gallbladder
carcinoma. Nine patients (9/24, 37.5%) had advanced disease at the time
of diagnosis and died within two months after being diagnosed with gall-
bladder carcinoma.
Conclusion: Gallbladder carcinoma is a rare cancer type in Iceland and
has a bad prognosis. One third of the patients had no connection with
Landspitali University Hospital following the diagnosis. Extended sur-
gery following the diagnosis was seldom performed.
Gallbladder carcinoma in Iceland 2004-2013
Bryndís Baldvinsdóttir1, Haraldur Hauksson2, Kristín Huld Haraldsdóttir1
1Department of Surgery, Landspitali University Hospital, 2Department of Surgery, Akureyri Hospital.
Key words: gallbladder carcinoma, gastrointestinal cancer, adenocarcinoma, extended cholecystectomy.
Correspondence: Kristín Huld Haraldsdóttir, kristinh@landspitali.is
að meðferð sjúklinga sé á fárra höndum og að þeir séu ræddir á
samráðsfundum sem eru mikilvægur vettvangur þar sem margar
sérgreinar koma að og geta gefið ráðleggingar varðandi meðferð.
Einnig er mikilvægt að hefja framskyggna skráningu í gagna-
grunn yfir alla einstaklinga sem greinast með gallblöðrukrabba-
mein á Íslandi, þar sem skráðar yrðu upplýsingar um greiningu og
meðferð. Með þeim hætti fáum við mælikvarða sem hjálpar okkur
að meta hvernig meðferð hérlendis er háttað miðað við þau lönd
sem við berum okkur saman við.