Læknablaðið : fylgirit - 01.05.1978, Qupperneq 49

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THE F1RST OAV OF AOMiNISTRATION
TlME (haur*)
I
*------------------*
08 iC 12 K 16 !6 20
íHE 10 Ih OAY Oí' AhMlNISTRATION
TlME(hours)
SIDE LFFECTS DURING BEXORYLATi:
TREATMFNT 22 patientr.
Sic!( eiiects Number of
paticnts
lncreased values of seriun
aspartate aminotransferase ö
Frolongation of bleeding
time 5
Patiioi. P+ P prothrombin
test 4
Microscopic haematuria 5
Microscopic leukocj’turia 5
Stool blood loss 2
Diarrhoea 2
Fig. 6 Paracetamol serum levels on the first
and lOth day of the test period.
The steady state in paracetamol serum levels
was reached aiready or. the second day of the
test. In morning samples during the steady state,
the mean paracetamol serum level was about 5
ug/ml, which is at the lowest limit of the thera-
peutic level. (Figure 5)
The maximum paracetamol serum concentration
was reached at two hours after intake of the drug.
After 6 hours, the serum levels had again fallen
to the lower limit of the therapeutic level.
According to this, the dosage intervals may be
too long, if benorylate is administered twice
daily. (Figure (>)
The ciinical results of tliese tests were not veiy
impressivc. Four children showet! a reductior. oí
morning stiffness, the mean number of aetive
joints showed only a slight reduction during the
test. The clinical effect was considered to be
good in two cases only.
The side effects in this series are seen in
Table 1
Conclusion:
In childrcn, the dosage of benorylatc c-f 200 r.'.y/
kg/day, divided in two doses, seems to l.>c
unsatisfactory for the management of rheumatoi;!
arthritis. Increased daily doses could be onc
solution as far as the higher dosage do not causc
mort side effects. I would also suggest, that
bcnorvlate should be administcred four times
daily. In this respcct, however, further
investigations are needed.
The content of sorbitol in the benoryiate mixture
is rather high, and may explair. a more rapid
passage tiirough tlie gut.
This probably is the most important reason to
diarrhoea, which mav impair the resorption of
the drug, and, whic.h in some cases may iead to
discountinuation oí the medication.
REFERENCES
Powell, R.K. and Ansell, B.M.:
Eenorylate in management of Still's disease.
liritish Med J 20 : i-iö 1974
47