Læknablaðið : fylgirit - 01.05.1978, Page 61

the lst and 5th day after the discontinuation of
the treatment.
Both naproxen and its metabolite, 6-demethy-
lated naproxen were determined in conjugated
and unconjugated forms.
Figure 4.: 70-90 per cent of naproxen is
excreted in conjugated form in the urine. The
excretion is expressed as milligrams in twenty-
four hours.
Figure 5.: Likewise, the napraxen metabolite,
6-demethylated naproxen, is mainly excreted in
conjugated form.
The amount of the various excretioh products
expressed as percentages of the total amount
excreted in the urine are shown in Figure 6.
70/o to 907o of both naproxen and its metabolite,
6-demethylated naproxen, were excreted in the
urine in conjugated form. The percentile
amounts did not vary during the whole test
period.
The excretion of naproxen as such, in
unconjugated form in the urine, calculated as
percentages of the oral daily dose is seen in
Figure 7. On an average, 10 per cent of the
oral daily dose is excreted as such, unchanged,
in the urine. This result is well in accordance
with those obtained by Runkel and his coworkers,
in adult patients discussed in the introduction of
this presentation.
Conjugated Naproxen, percents of total Naproxen in urine D
•• Metabolite. •■ •• •■ Metabolite.............
per cent
Fig. 6 Amounts of the conjugated forms of
naproxen and its metabolite, calculated in
percentages from the corresponding total
excretions in the urine.
per cent Unconjugated Naproxen in urine
Days of treatment 1
Fig. 7 Unconjugated napraxen in urine percents
of oral daily dose.
Mean * S.D.
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