Læknablaðið : fylgirit - 01.05.1978, Page 84

Fig. 1
Flg. 2
Figure 1 . Clinical results of treatment with
90Y in knee-joint arthritis.
effect of intra-articular 90Y treatment on knee-
joint arthritis. Of the 33 treated patients, 3
died and 3 others were excluded from the study
for other reasons.
Excellent or good results were recorded in
74% at 3 months, in 77% at 6 months, in 53% at
1 year, in 44% at 2 years, and in 4C% at 3.5
years. In 19 patients with bilaterai arthritis
improvement of the 90Y treated knee-joint was
noted in 10 (52%) as against 5 (26%) of the control
joint at the last check-up at 3.5 years (Figure
2 and Table II).
The roentgenological picture of the 90Y treated
knee in 13 out of 1 8 patients was unchanged (one
patient was not investigated) as against 12 of
the controls, while progress could be detected
in 5 treated and 6 controls (Figure 3).
In 4 patients with unsatisfactory results severe
articular destruction and instability were noted.
In 1 patient 90Y was given bilaterally, the thera-
peutic result was excellent in the left knee, the
right knee did not respond to the given therapy
and showed severe roentgenological destruction.
In 7 patients the therapeutic result was excellent
in spite of generally high progressing disease
activity. In 2 patients a trauma of the treated
knee caused relapse of the arthritis, in spite of
initial excellent clinical results. In another case
post-traumatic arthrography resulted in septic
arthritis. Four patients, with generally high
disease activity, who did not respond to local
3
2 s . 0 -M *s É
No.of
Pot.
Figure 2. Clinical results of treatment of
bilateral knee-joint arthritis. Comparison
between 90Y-treated and control knee.
treatment, improved when the general therapy
was changed.
Assessment of correlation between clinical
diagnosis and therapeutic results in 18 RA patients
showed 6 excellent, 2 good, and 7 poor results.
Two patients died during the observation period
and 1 were withdrawn from the study for other
reasons. Among 3 patients with PSP plus RA
the response was good in 2, and could not be
assessed in 1. In 5 patients with seronegative
polyarthritis the response was excellent in 1,
poor in 3, and could not be assessed in 1.
Among 7 PSA patients the response was good in
1, poor in 5, and 1 patient was excluded from
the study. The treatment seems to be most
successful in RA patients and unsatisfactory in
PSA patients (Figure 4).
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