Læknablaðið : fylgirit - 01.08.2003, Page 84

I POSTERS / 27TH NORDIC PSYCHIATRIC CONGRESS
ing an important role in cell second messengering. Anorexia ner-
vosa (AN) is a disorder characterized by aberrant eating behavior,
a desire to lose weight and fear of becoming obese. A relation be-
tween AN and disturbances in PLD system has never been ex-
plored before. Changes of PLD activity after phototherapy are also
an original idea worth exploring.
The study aimed at characterization of PLD activity in blood
platelets in female AN patients treated with fluvoxamine (100
mg/d) or phototherapy with a group without a treatment.
The examined group consisted of 7 patients on fluvoxamine and
9 receiving phototherapy. The control group was 25 healthy girls.
PLD activity was assessed according to Strosznajder and Zhou et al.
before the treatment and after 6 weeks [1,2].
The activity of PLD in AN patients before and after the treat-
ment was 1.353 and 1.358 nmol/mg/min in fluvoxamine group, and
1.471 and 1.438 nmol/mg/min in phototherapy group. The activity
measured in the controls was 1.367 nmol/mg/min. There were no
statistically significant differences between the examined groups.
Both phototherapy and fluvoxamine do not seem to change
PLD activity in blood platelets in AN patients after 6 weeks of
treatment.
References
1. Strosznajder J, Strosznajder RP. Guanine nucleotides and fluoride enhance
carbachol-mediated arachidonic acid release from phosphatidylinositol. Evi-
dence for infolvement of GTP-binding protein on phospholipase A2 activation.
J Lipid Mediat 1989; 1: 217-29.
2. Zhou M, Diwu Z, Panchuk-Voloshina N, Haugland RP: Developmental changes
in phospholipase D activity and mRNA levels in rat brain. Anal Biochem 1997;
253:162-8.
P - 94 Friday 15/8,14:00-15:00
Parkinson’s disease and clozapine-induced aplastic
anaemia
Marc Zicgcnhcin. MD, Social Psychiatry and Psychotherapy, Medical School Hanno-
ver, Carl-Neuberg-Str.l, 30625 Hannover, Germany. Anja Steinbrecher, MD, Neuro-
logy and Clinical Neurophysiology, Medical School Hannover, Germany, Petra Gar-
lipp, MD, Social Psychiatry and Psychotherapy, Medical School Hannover, Germany.
mziege999@yahoo.com
Psychosis is a common complication of the drug treatment of
Parkinson’s disease. All patients suffering from idiopathic Parkin-
son’s disease are at risk of developing delusions or hallucinations.
The most prominent psychotogenic factors are dopaminomimetic
agents, which may induce dopamine hypersensitivity in the frontal
and limbic dopamine projection regions, and consequently, either
directly or indirectly, elicit psychotic signs and symptoms. A Parkin-
son’s disease-related cholinergic deficit in combination with an age-
related further loss of cholinergic integrity also plays a prominent
role. Treatment of this complication is difficult, as most typical anti-
psychotic drugs, because of their selective dopamine receptor anta-
gonistic effects, worsen motor symptoms of Parkinson’s disease. As
a consequence of a non-selective antagonism at both serotonergic
and dopaminergic receptors, atypical antipsychotics such as cloza-
pine, are associated with fewer extrapyramidal side-effects. Cloza-
pine treatment is associated with wide side-effects such as blood-
cell dyscrasias, including transient granulocytosis, benign granulo-
cytopenia, and a considerable risk of agranulocytosis as high as 0.5-
1%, transient fever, sedation, and considerable body weight gain.
The mechanisms underlying these side effects are still unknown,
but recent data suggest that the metabolism of clozapine and its im-
munmodulatory effects might play a role. Aplastic anaemia, com-
prising all its features, during clozapine therapy has not been docu-
mented in the literature. Herein we present a case of clozapine-
induced aplastic anaemia.
P - 95 Friday 15/8, 14:00-15:00
Transferred to an oral presentation
P - 96 Friday 15/8,14:00-15:00
Patterns of bipolar swings - the usefulness of “life-
charting”
Lcna BuckluncL Karolinska Institutet, Neurotec Department, Division of Psychi-
atry, Huddinge University Hospital, 141 86 Stockholm, Sweden. Göran Isacsson,
Hans Ágren.
lena.backlund@slpo.sll.se
For the study of factors predicting the long-time course of bipolar
disorder, we used a life-charting methodology to study a random
sample of 60 patients diagnosed wilh bipolar disorder (26 men, 34
women; 48 Bipolar 1,12 Bipolar II).
A descriptive analysis showed 16 subjects with a first illness epi-
sode under age 18 (27%); 37 had been psychotic (62%). Since onset
of illness subjects had spent more than one fifth of their lives
acutely ill. The time span between onset of illness and receiving
psychiatric care was at average 3 years, and until receiving mood-
stabilizers nearly 13 years. On mood-stabilizers, the frequency of
episodes decreased substantially, particularly in subjects whose first
episode was manic. Fifty-one subjects had heredity for affective dis-
order (85%). In the 16 with affective siblings, functioning was less
affected by the illness and the time spent in mania was shorter.
Maybe individuals with affected siblings are better informed, seek-
ing psychiatric treatment earlier and thus achieving a better prog-
nosis.
These preliminary results support the concern that bipolar dis-
order is an illness with a largely juvenile onset, having a major im-
pact on the affected person’s course of life, and with a prognosis
that it is possible to influence with mood-stabilizers.
84 LÆKNABLAÐIÐ / FYLGIRIT 48 2003/89