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Læknablaðið - jan 2019, Qupperneq 16

Læknablaðið - jan 2019, Qupperneq 16
16 LÆKNAblaðið 2019/105 R A N N S Ó K N 1. Bakker MK, Jentink J, Vroom F, Van Den Bert PB, De Walle HE, De Jong-Van Den Berg D. Drug prescription patterns before, during and after pregnancy for chronic, occasional and pregnancy-related drugs in the Netherlands. BJOG 2006; 113: 559-68. 2. Daw JR, Hanley GE, Greyson DL, Morgan SG. Prescription drug use during pregnancy in developed countries: a systematic review. Pharmacoepidemiol Drug Saf 2011; 20: 895-902. 3. Gagne JJ, Maio V, Berghella V, Louis DZ, Gonnella JS. Prescription drug use during pregnancy: a population- based study in Regione Emilia-Romagna, Italy. Eur J Clin Pharmacol 2008; 64: 1125. 4. Chambers C. Over-the-counter medications: Risk and safety in pregnancy. Sem Perinatol 2015; 39: 541-4. 5. Adam MP, Polifka JE, Friedman JM. Evolving knowledge of the teratogenicity of medications in human pregnancy. Am J Med Genet C Sem Med Genet 2011; 157: 175-82. 6. Nordeng H, Ystrøm E, Einarson A. Perception of risk regarding the use of medications and other exposures during pregnancy. Eur J Clin Pharmacol 2010; 66: 207-14. 7. Hämeen-Anttila K, Jyrkkä J, Enlund H, Nordeng H, Lupattelli A, Kokki E. Medicines information needs during pregnancy: a multinational comparison. BMJ Open 2013;3(4). 8. Zaki NM, Albarraq AA. Use, attitudes and knowledge of medications among pregnant women: A Saudi study. Saudi Pharmaceut J 2014; 22: 419-28. 9. Nordeng H, Koren G, Einarson A. Pregnant Women’s Beliefs About Medications - A Study Among 866 Norwegian Women. Ann Pharmaco 2010; 44: 1478-84. 10. Phatak HM. Relationships Between Beliefs about Medications and Nonadherence to Prescribed Chronic Medications. Ann Pharmaco 2006; 40: 1737-42. 11. Bánhidy F, Lowry RB, Czeizel AE. Risk and Benefit of Drug Use During Pregnancy. Int J Med Sci 2005; 2: 100-6. 12. Hancock RL, Koren G, Einarson A, Ungar WJ. The effect- iveness of Teratology Information Services (TIS). Reprod Toxicol 2007; 23: 125-32. 13. Aronsson CA, Vehik K, Yang J, Uusitalo U, Hay K, Joslowski G. Use of dietary supplements in pregnant women in relation to sociodemographic factors – a report from The Environmental Determinants of Diabetes in the Young (TEDDY) study. Publ Health Nutr 2013; 16: 1390-402. 14. Headley J, Northstone K, Simmons H, Golding J, ALSPAC Study Team. Medication use during pregnancy: data from the Avon Longitudinal Study of Parents and Children. Eur J Clin Pharmacol 2004; 60: 355-61. 15. Sato Y, Nakanishi T, Chiba T, Yokotani K, Ishinaga K, Takimoto H, et al. Prevalence of Inappropriate Dietary Supplement Use Among Pregnant Women in Japan. Asia Pacif J Clin Nutr 2013; 22: 83-9. 16. Kennedy DA, Lupattelli A, Koren G, Nordeng H. Safety classification of herbal medicines used in pregnancy in a multinational study. BMC Complement Altern Med 2016; 16. 17. Orief YI, Farghaly NF, Ibrahim MIA. Use of herbal med- icines among pregnant women attending family health centers in Alexandria. 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Zoega H, Kieler H, Nørgaard M, Furu K, Valdimarsdottir U, Brandt L, et al. Use of SSRI and SNRI Antidepressants during Pregnancy: A Population-Based Study from Denmark, Iceland, Norway and Sweden. PLoS ONE 2015; 10(12). 25. Baldvinsdóttir D. Notkun þunglyndislyfja á með- göngu meðal kvenna á Íslandi 2003-2012: Lýðgrunduð rannsókn á landsvísu (meistaraprófsritgerð, Háskóli Íslands, Reykjavík). 2016. https://skemman.is/hand- le/1946/25180?locale=en - ágúst 2018. 26. Guðmundsdóttir Þ. Rannsókn á lyfjanotkun barnshafandi kvenna á Íslandi. Óútgefin kandídatsritgerð, Háskóli Íslands, Reykjavík 2001. 27. landlaeknir.is – febrúar 2018. 28. Milunsky A, Jick H, Jick SS, Bruell CL, MacLaughlin DS, Rothman KJ, et al. Multivitamin/folic acid supplementa- tion in early pregnancy reduces the prevalence of neural tube defects. JAMA 1989; 262: 2847-52. 29. De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC, Rayco-Solon P. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochr Datab Syst Rev 2015; (12): CD007950. 30. Al Rakaf MS, Kurdi AM, Ammari AN, Al Hashem AM, Shoukri MM, Garne E, et al. Patterns of folic acid use in pregnant Saudi women and prevalence of neural tube defects—Results from a nested case–control study. Prevent Med Report 2015; 2: 572-6. 31. Hodgetts VA, Morris RK, Francis A, Gardosi J, Ismail KM. Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: a population study, systematic review and meta-analysis. BJOG 2015; 122: 478-90. 32. Schaefer C, Hannemann D, Meister R. Post-marketing surveillance system for drugs in pregnancy—15 years experience of ENTIS. Repro Toxicol 2005; 20: 331-43. Heimildir Barst til blaðsins 10. ágúst 2018, samþykkt til birtingar 27. nóvember 2018. Unnur Sverrisdóttir1 Freyja Jónsdóttir1,2 Anna Ingibjörg Gunnarsdóttir1,2 Hildur Harðardóttir3,4 Ragnheiður Ingibjörg Bjarnadóttir4,5 Introduction: Evidence-based information regarding the use of medication during pregnancy is lacking, even though the use of medication during pregnancy is considered common and often neccesary. The aim of this study was to obtain reliable information on the use of medications during the first 20 weeks of pregnancy and the use of vitamins, minerals, fatty acids, herbs and other natural products. Women´s attitude and beliefs towards the use of medications was also examined. Material and methods: The study was conducted at the Prenatal Diagnosis Unit at Landspitali from January to April 2017. Women who attended routine ultrasound examination at 20 weeks were offered to participate. A questionnaire was submitted to partici- pants in an interview with the researcher following the doctor’s appointment. Results: Of the 213 participants, 90% used medication at least once during the first 20 weeks of pregnancy. Approximately 80% of these medications belong to FASS safety classes A and B and are considered safe during pregnancy. The proportion of women who did not use folic acid was 14% which was associated with residence in rural areas (p=0.03) and younger age (p=0.019). Natural products were used by 14% but information about their safety is lacking. The majority (81%) was satisfied with the information they received when a drug was prescribed and 94% said they had sufficient access to information about medication use during pregnancy. The most commonly used sources of information were the internet (51%) and the local midwive (44%). Conclusion: The use of medications and supplements during pregnancy is common. Most medications being used are considered safe during pregnancy. The majority of pregnant women take folic acid. Pregnant women have a logical and gener- ally a positive attitude towards medication use during pregnancy. Use of medication, supplements and natural products during pregnancy ENGLISH SUMMARY 1Faculty of Pharmaceutical sciences, The University of Iceland, 2Pharmacy department, The National University Hospital, 3Obstetrics and gynecology, The National University Hospital, 4Faculty of Medicine, The University of Iceland, 5The Primary health care of the capital area. Key words: pregnancy, medication, natural product, supplement, attitude, knowledge. Correspondence: Unnur Sverrisdóttir, unnursve@gmail.com

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