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Læknablaðið - sep. 2019, Blaðsíða 24

Læknablaðið - sep. 2019, Blaðsíða 24
384 LÆKNAblaðið 2019/105 R A N N S Ó K N Aðalbjörg Albertsdóttir1 Árún K. Sigurðardóttir2,3 Björg Þorleifsdóttir4 Background: Sleep disturbances are common, underdiagnosed and have negative consequences for people with multiple scler- osis. Objective: Gather information about the prevalence of poor sleep quality and sleep disturbances in Icelanders with multiple scler- osis. Method: A cross-sectional self-report survey. Population: Icelanders with multiple sclerosis. Sample: People with multiple sclerosis, who were on the online mailing list or had access to Facebook groups of the Multiple-Sclerosis-Society in Iceland. An electronic link with background questions and 4 questionnaires was available to participants. Questionnaires: The Pittsburgh- Sleep-Quality-Index (PSQI), the Insomnia-Severity-Index, the STOP-Bang-questionnaire and 5 diagnostic criteria for restless legs syndrome. Questionnaires were used to screen for poor sleep quality, and 7 different factors that can cause disturbed sleep. Data was analyzed with SPSS version 25. Results: Almost 40% of Icelanders with multiple sclerosis participated or 234 persons. Mean age was 47 years (range 20-92) and 77% were female. The prevalence of poor sleep quality (PSQI>5), was 68%. The factors that most often caused distur- bed sleep were; bathroom breaks (39%), pain (37%), insomnia symptoms (30%) and sleep apnea symptoms (24%). Majority of participants or 79% had at least one sleep disturbance and on average they had close to two. Insomnia symptoms were strongly related to poor sleep quality. Conclusion: High prevalence of poor sleep quality and sleep disturbances in people with multiple sclerosis needs to be addressed. PSQI can be used to screen for poor sleep quality and to assess whether further sleep evaluation is needed. Screening, diagnosis and treatment of insomnia should be implemented. Prevalence of Poor Sleep Quality and Sleep Disturbances in Icelanders with Multiple Sclerosis ENGLISH SUMMARY 1Reykjalundur rehabilitation center, Mosfellsbaer Iceland, 2University of Akureyri, Akureyri Iceland, 3Akureyri Hospital, Akureyri, Iceland, 4Department of Physiology, Faculty of Medicine, University of Iceland. Key words: Multiple sclerosis, sleep quality, sleep disturbances, obstructive sleep apnea, restless legs syndrome, insomnia. Correspondence: Aðalbjörg Albertsdóttir, adalbjorg.alberts@reykjalundur.is 1. ncbi.nlm.nih.gov/books - janúar 2019. https://www.ncbi. nlm.nih.gov/books/NBK248064/ 2. Lunde HMB, Bjorvatn B, Myhr K-, Bø L. Clinical assessment and management of sleep disorders in multiple sclerosis: a literature review. Acta Neurol Scand 2013; 127: 24-30. 3. Ma S, Rui X, Qi P, Liu G, Yang J. Sleep disorders in patients with multiple sclerosis in China. Sleep Breath 2017; 21: 149-54. 4. Braley TJ, Segal BM, Chervin RD. Obstructive sleep apnea and fatigue in patients with multiple sclerosis. J Clin Sleep Med 2014; 10: 155-62. 5. Brass SD, Li C, Auerbach S. The underdiagnosis of sleep disorders in patients with multiple sclerosis. J Clin Sleep Med 2014; 10: 1025-31. 6. Strober LB. Fatigue in multiple sclerosis: A look at the role of poor sleep. Front Neurol 2015; 6: 21. 7. Minden SL, Frankel D, Hadden L, Perloff J, Srinath KP, Hoaglin DC. The Sonya Slifka longitudinal multiple scler- osis study: methods and sample characteristics. Mult Scler 2006; 12: 24-38. 8. Fisk JD, Pontefract A, Ritvo PG, Archibald CJ, Murray TJ. The impact of fatigue on patients with multiple sclerosis. Can J Neurol Sci 1994; 21: 9-14. 9. Braley TJ, Boudreau EA. Sleep disorders in multiple scler- osis. Curr Neurol Neurosci Rep 2016; 16: 50.11. Darien IL (ritsj). International classification of sleep disorders– third edition. American Academy of Sleep Medicine, U.S.A 2014. 10. Côté I, Trojan D, Kaminska M, Cardoso M, Benedetti A, Weiss D, et al. Impact of sleep disorder treatment on fatigue in multiple sclerosis. Mult Scler 2013; 19: 480-9. 11 Darien IL (ritsj). International classification of sleep disorders–third edition. American Academy of Sleep Medicine, U.S.A 2014. 12. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193-213. 13. Mollayeva T, Thurairajah P, Burton K, Mollayeva S, Shapiro CM, Colantonio A. The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: a systematic review and meta- analysis. Sleep Med Rev 2016; 25: 52-73. 14. Elíasdóttir Ó, Kjartansson Ó, Olafsson E. Prevalence of multiple sclerosis in Iceland. Neuroepidemiology 2018; 51: 50-6. 15. hagstofa.is – hagstofa.is/utgafur/frettasafn/mannfjoldi/ mannfjoldinn-a-3-arsfjordungi-2018/ - janúar 2019. 16. Albertsdóttir A, Sigurðardóttir AK, Þorleifsdottir B. Rannsókn á svefngæðum fólks með MS á Íslandi. MS-blaðið 2018; 35: 22-3. msfelag.is/static/files/Greinar/ LyfogMedferdir/msbladid_201802_adalbjorgalberts_ svefngaedi.pdf 17. msfelag.is - msfelag.is/is/felagid/frodleikur/frettir/ konnun-a-svefngaedum-folks-med-ms-a-islandi – janúar 2019. 18. Hinz A, Glaesmer H, Brähler E, Löffler M, Engel C, Enzenbach C, et al. Sleep quality in the general population: psychometric properties of the Pittsburgh sleep quality index, derived from a German community sample of 9284 people. Sleep Med 2017; 30: 57-63. 19. Þórðardóttir EB. Long-term health consequences of avalanches in Iceland in 1995: A 16 year follow-up. Thesis for the degree of Philosophiae Doctor. University of Iceland, Reykjavík 2016. hdl.handle.net/1946/24937 – jan- úar 2019. 20. Bastien CH, Vallières A, Morin CM. Validation of the Insomnia severity index as an outcome measure for insomnia research. Sleep Med 2001; 2: 297-307. 21. Morin CM, Belleville G, Bélanger L, Ivers H. The Insomnia severity index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep 2011; 34: 601- 8. 22. Nagappa M, Liao P, Wong J, Auckley D, Ramachandran SK, Memtsoudis S, et al. Validation of the STOP-Bang questionnaire as a screening tool for obstructive sleep apnea among different populations: a systematic review and meta-analysis. PLoS ONE 2015; 10: e0143697. 23. irlssg.org/diagnostic-criteria – janúar 2019. 24. Hulsen T, Vlieg Jd, Alkema W. BioVenn – a web app- lication for the comparison and visualization of biological lists using area-proportional Venn diagrams. BMC Genomics 2008; 9: 488. 25. Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Ludice A, Murri L, et al. Multicenter case-control study on restless legs syndrome in multiple sclerosis: The REMS Study. Sleep 2008; 31: 944-52. 26. Bauters F, Rietzschel ER, Hertegonne KBC, Chirinos JA. The link between obstructive sleep apnea and cardiovascular disease. Curr Atheroscler Rep 2016; 18: 1. 27. Walker M. Why We Sleep. Scribner, New York 2017. 28. Sateia MJ. International Classification of Sleep Disorders- Third Edition. CHEST 2014; 146: 1387-94. Heimildir Barst til blaðsins 2. apríl 2019, samþykkt til birtingar 7. ágúst 2019.
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