Læknablaðið - 01.06.1977, Page 28

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LÆKNABLAÐIÐ
SUMMARY
Elín Ólafsdóttir and Alfreð Árnason
Frequency of „atypical“ serum cholinester-
ase.
One member of a large family had previously
been diagnosed with an „atypical" serum
cholinesterase. Serum samples from five sisters
and brothers and four children of that member
were analysed with respect to „atypical"
serum cholinesterase. Four members were
shoiwn to be homozygous with respect to the
„atypical" cholinesterase gene (E^E^a), but
six were heterozygous with respect to the
„atypical" gene (E^E^a).
Gene frequency for E,a was estimated on 415
randomly sampled sera. The genefrequency was
calculated 0.0205 and from that one would
expect one in every 2400 Icelanders to be
homozygous with respect to the „atypical"
cholinesterase gene.
ÞAKKARORÐ
Við þökkum forráðamönnum Hjarta-
verndar fyrir gjöf á serumsýnum og Eddu
Emilsdóttur, meinatækni, fyrir ötula að-
stoð við rannsóknarstörf.
HEIMILDASKRÁ
1. Agarwal, D.P., Schwenkenbecker, S„ Sriva-
stava, L.M. og Goedde, H.W. A specthro-
photometric method for the determination
of serum cholinesterase variants with suc-
cinil choline as substrate, Z.Klin.Chem,-
Klin.Biochem. 13:133, 1975.
2. Agarwal, D.P., Schwenkenbecker, S. og
Goedde, H.W. New serum cholinesterase
variants detected by using the muscle re-
laxant succinyldicholine as substrate. Tenth
International Congress of Biochemistry Ah-
stracts, Hamburg, 1976, 13-1-197.
3. Árnason, A. og Bjarnason, Ó. Post mortem
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vegna arfgengs skorts á serumcholinester-
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