Læknablaðið - 01.10.2017, Page 36

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R A N N S Ó K N
ENGLISH SUMMARY
Introduction: Heart failure (HF) is a common and a serious condition
that predominantly affects elderly people. On the basis of the left
ventricular ejection fraction (EF) it can be divided into HF with reduced or
preserved ejection fraction (HFrEF and HFpEF, respectively). The goal of
this study was to investigate the prevalence and incidence of HF among
elderly Icelanders, explore underlying diseases and estimate the effect
of HF on overall survival.
Material and methods: Included were 5706 participants of the AGES
study. The hospital records of those diagnosed with HF before entry
into AGES were used to calculate prevalence and the records of those
diagnosed from entry into AGES until 28.2.2010 were used to calculate
incidence. All cases of HF were verified according to predetermined
criteria for diagnosis. Information on underlying diseases and EF of HF
patients were obtained from hospital records. Survival was estimated
using Kaplan-Meier survival curves.
Results: Lifetime prevalence of HF was 3.6% as of 2004, higher among
men than women (p<0,001). The incidence was 16.2 cases per 1000
person-years, higher among men than among women (p<0,001). The
incidence of HFrEF was 6.1 per 1000 person-years also higher among
men than women (p<0,001). The incidence of HFpEF was 6.8 per 1000
person-years and there was no statistical difference between the sexes
(p=0.62). The age adjusted 5-year survival rate of HF-patients was
32.5%, there was no statistical difference in relative survival between
men and women (p=0.46). There was no statistical difference between
the survival of patients with HFrEF and those with HFpEF (p=0.52).
Conclusion: Both prevalence and incidence of HF are high among eld-
erly Icelanders, increasing sharply with age and 5-year survival rate is
only around 30%. While men are more likely to develop HF, especially
HFrEF, women are more likely to be diagnosed with HFpEF.
Heart failure among elderly Icelanders: Incidence, prevalence, underlying diseases and long-term survival
Haukur Einarsson1, Guðmundur Þorgeirsson1,2,3, Ragnar Danielsen1,2 , Örn Ólafsson3, Thor Aspelund1,3, Vilmundur Guðnason1,3
1University of Iceland Medicine, 2Landspítali University Hospital, 3Icelandic Heart Association
Keywords: heart failure, HFrEF, HFpEF og AGES-Reykjavik Study.
Correspondence: Haukur Einarsson haukure77@gmail.com
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