Læknablaðið - 01.08.1970, Side 59

LÆKNABLAÐIÐ
135
It is thought probable, that the mutant gene present in the two fam-
ilies and the one previously described,0 has originated from a common
ancestor in the area. Efforts to find such a relationship by genealogical
approach have not been successful yet.
The bleeding times have been found normal in all affected individuals,
when tested in the asymptomatic phase, whereas it has been prolonged,
when symptoms of bleeding were present.
The estimations of coagulation factors were performed at the Statens
Seruminstitut in Copenhagen on frosen plasma samples sent by air.
HEIMILDIR
1. Alexander, B. & Goldstein, R.: Dual hemostatic defect in pseudo-
hemophilia. J. Clin. Invest. 32:551, 1953.
2. Biggs, R. & Matthews, J. M.: The treatment of haemorrhage in von
Willebrand’s disease and the blood level of factor VIII (AHG). Brit.
J. Haemat. 9:203, 1963.
3. Cornu, P., Larrieu, M.D., Caen, J. & Bernard, J.: Transfusion studies
in von Willebrand’s disease: effects on bleeding time and factor VIII.
Brit. J. Haemat. 9:189, 1963.
4. Duke, W. W.: The pathogenesis of purpura haemorrhagica with
especial reference to the part played by the blood-platelets. Arch.
intern. Med. 10:445, 1912.
5. Hardisty, R. M., Dormandy, K. M. & Hutton, R. A.: Thrombasthenia
studies on three cases. Brit. J. Haemat. 10:371, 1964.
6. Jensson, Ó. and Wallett, Leon H.: Von Willebrand’s disease in an
Icelandic family. Acta Med. Scand. 187, 229, 1970.
7. Kaneshiro, M. M., Mielke, C. H., Kasper, C. K. and Rapaport, S. I.:
Bleeding time after asperin in disorders of intrinsic clotting. New Eng.
J. Med„ 281, 1039, 1969.
8. Lee, R. I. & White, P. D.: A clinical study of the coagulation time of
blood. Amer. J. Med. Sci., 145, 1913.
9. MacFarlane, R. G.: International review of experimental pathology.
Vol. 6, p. 119. Academic Press, New York and London 1968.
10. Nilsson, I. M., Blomback, M. & von Francken, I.: On an inherited
autosomal haemorrhagic diathesis with antihemophilic globulin (AHG)
deficiency and prolonged bleeding time. Acta Med. Seand. 159:35, 1957.
11. Nilsson, I. M„ Blombáck, M„ Jorpes, E„ Blombáck, B. & Johannsson,
S.: von Willebrand’s disease and its correction with human plasma
Fraction 1—10. Acta Med. Scand. 159:179, 1957.
12. O’Brien, J. R.: Effects of anti-inflammatory agents on platelets.
Lancet, ii, 894, 1968.
13. O’Brien, J. R.: Effects of salicylates on human platelets. Lancet, ii,
779, 1968.
14. Quick, A. J.: Acetylsalicylic acid as a diagnostic aid in hemostasis.
Amer. J. Med. Sci. 245, 392, 1967.
15. Pitney, W. R. & Arnold, B. J.: Plasma antihaemophilic factor (AHG)
concentrations in families of patients with haemorrhagic states. Brit.
J. Haemat. 5:184, 1959.