Læknablaðið - 01.02.1971, Page 67

LÆKNABL AÐIÐ
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increase in heart rate of 30% ±14.1. The calculated total periferal resist-
ance decreased 42% ±9.8.
The litterature is reviewed briefly and it is concluded that diazoxide,
when administered intravenously, is an excellent drug in the treatment of
acute hypertension.
Its advantages include an immediate onset of action, lack of drug
resistance, few side effects and an increase in cardiac output which
decreases the danger of hypotension and vascular collapse secondary to
a marked decrease in vascular resistance.
HEIMILDIR
1. Conway, J. and Lauwers, P.: Hemodynamic and hypotensive effects
of long-term therapy with chlorothiazide; Circulation 21:21, 1960.
2. Lauwers, P. and Conway, J.: The effect of long-term treatment with
chlorothiazide on body fluids, serum electrolytes, and exchangable
sodium in hypertensive patients; J. Lab. and Clin. Med. 56:401, 1960.
3. Blanckard, W. G. and Aprill, C. N.: Mechanism of action of diazoxide;
J. Lab. and Clin. Med. 69:960, 1967.
4. Grabner, A. L., Porte, D. Jr. and Williams, R. H.: Clinical use of
diazoxide and mechanism for its hypoglycemic effects; Diabetes
15:143, 1966.
5. Frohlich, E. D., Ulrych, M., Tarazi, R. C., Dustan, H. P. and Page,
I. H.: A hemodynamic comparison of essential and renovascular
hypertension; Circulation 35:289, 1967.
6. Finnerty, Frank, A„ Kakaviatos, N., Tuckman, J. and Magill, J.:
Clinical evaluation of diazoxide. A new treatment for acute hyper-
tension; Circulation 28:203, 1963.
7. Wilson, R. W. and Okun, R.: Acute hemodynamic effects of diazoxide
in man; Circulation 28:89, 1963.
8. Hamby, W. M„ Jankowski, G. J„ Pouget, M. J„ Dunea, G. and Guatt,
C. L.: Intravenous use of diazoxide in the treatment of severe hyper-
tension; Circulation 37:169, 1968.
9. Finnerty, F. A„ Davidov, M. and Kakavitos, N.: Hypertensive vas-
cular disease. The long term effect of rapid repeated reduction of
arterial pressure with diazoxide; The Am. J. of Cardiol. 19:377, Í967.
10. Kakaviatos, N. and Finnerty, F. A.: Preliminary observations of the
value of diazoxide administered intravenously in man; Angiology
13:541, 1962.
11. Zitowitz, L. and Ruben, A. A.: Some acute cardiovascular actions of
diazoxide, a non-diuretic antihypertensive benzothiadiazine; Fed. Proc.
21:114, 1962.
12. Rowe, G. G„ Leicht, T. R„ Boake, W. C„ Kyle, J. C. and Crumpton,
C. W.: The systemic and coronary hemodynamic effects of diazoxide;
Am. Heart J. 66:634, 1963.
13. Black, J.: Diazoxide and treatment of hypoglycemia: historical review;
Ann. New York Acad. Sc. 150:194, 1968.
14. Steinke, J. and Soeldner, J. S.: Metabolic effects of diazoxide in nor-