Læknablaðið - 15.05.1985, Side 9

LÆKNABLAÐIÐ
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dreyrasýki A (23) sem hafa ÁÓB. Nýlegar
rannsóknir sýna, að margir blæðarar með
dreyrasýki A hafa mótefni gegn þeirri veiru
burtséð frá því, hvort þeir hafa ÁÓB einkenni
eða ekki (24).
Hlutfallslegur fjöldi þeirra blæðara, sem
hafa mótefni gegn HTLV-III veirunni fer
vaxandi með tímanum (24). Hvort okkar
blæðarar hafa mótefni gegn HTLV-III veir-
unni hefur ekki verið kannað.
ADDENDUM
Sermi úr áðurnefndum sjúklingum hafa ný-
lega verið rannsökuð með tilliti til, hvort
þeir hefðu mótefni gegn »AIDS associated
retrovirus (ARV)« sem sennilega er eins og
HTLV-III (Levy JA et. al. Science 1984; 225:
840-2). Rannsóknin var gerð af Jan C. Ulstrup
yfirlækni á »Mikrobiologisk laboratorium
Ullevál sykehus« í Osló. Við prófið voru
notaðar ARV sýktar eitilfrumur einangraðar
úr hommum. Til að bera kennsl á mótefnin
sem bindast ARV sýktum eitilfrumum var
síðan notað kanínu IgG anti-manna IgG sem
merkt var með FITC og frumurnar síðan
taldar samtímis með smásjárskoðun í venju-
legu og útfjólubláu ljósi.
Enginn blæöaranna (nr. 1) reyndist hafa
mótefni gegn ARV.
ÞAKKARORÐ
Við þökkum Dr. Tor Lea á »Institutt for generell og
revmatologisk immunologi Rikshospitalet« i Osló fyrir
að láta í té sérvirk kanínu IgG mótefni gegn músa IgG
mótefnum og Dr. Jan Dobloug á »Avdeling 1 Ullevál
sykehus« i Osló fyrir að koma í kring mælingum á
mótefnum gegn ARV. Einnig þökkum við Birgittu
Birgisdóttur líffræðingi á Rannsóknarstofu Landa-
kotsspítala fyrir aðstoð við mótefnamælingar og
Sveindísi Þórisdóttur læknafulltrúa í Blóðbankanum
fyrir vélritunarstörf.
SUMMARY
We have investigated the cellular and humoral immune
status in five Icelandic individuals with hemophilia A
rangingin agefrom 16-61 years, mean 30years.Eachwas
investigated twice, with 18 months interval from July
1983 to November 1984. All have been treated with factor
VIII cryoprecipitate from Finland. The average amount
used forthepast fiveyears was 94.300IU peryear ranging
from 2.000 to 217.000 IU per year. In November 1984 one
bleeder had hepatitis B surface antigen and four had
antibodies to it. In the previous investigation with
another technique neither hepatitis B surface antigen nor
antibody had been detected.
In both investigations serum IgG levels were found to
be higher among the haemophiliacs than among the
controls (p<0.01, Students t-test). In the time interval
between the two investigations the concentration of IgM
increased significantly (p< 0.001). It was however still
within normal range in four of the five cases.
The proportion and absolute number of different
mononuclear cell types and subtypes showed small
deviations above and below the range of the control
group.
These immunologic findings are similar to those
described in recent reports in haemophiliacs treated with
intermediately purified lyophilised factor VIII cryopreci-
pitates.
HEIMILDIR
1) Dent PB. Immunodepression by oncogenic viruses.
Prog Med Virol 1972; 14: 1-35.
2) Klepp O, Dahl O, Stenwig JT. Association with
immunosuppressive therapy. A 5-year material of
Kaposi’ssarcomainNorway. Cancer 1978; 42:2626-
30.
3) Urmacher C, Myskowski P, Ochoa M, Kris M, Safai
B. Outbreak of »Kaposi’s Sarcoma« with cytomega-
lovirus infection in young homosexual men. Am J
Med 1982; 72: 569-75.
4) Arneborn P, Biberfeld GT. Lymphocyte subpopula-
tions in relation to immunosuppression in measles
and varicella. Infect Immunity 1983; 39: 29-37.
5) Gottlieb MS, Schroff R, Schanker HM, Weisman
JD, Fan PT, Wolf RA, Saxon A. »Pneumocystis
carinii« pneumonia and mucosal candidiasis in
previously healthy homosexual men. Evidence a new
acquired cellular immunodeficiency. New Engl J
Med 1981; 305: 1425-31.
6) Masur H, Michelis MA, Greene JB, Onorato I,
Vande Stouwe RA, Holzman RS, Wormser G,
Brettman L, Lange M, Murray HW, Cunningham-
Rundles S. An outbreak of community-acquired
»pneumocystis carinii« pneumonia. Initial manife-
station of cellular immune dysfunction. New Engl J
Med 1981; 305: 1431-8.
7) Centers for Disease Control. nPneumocystis carnii«
pneumonia among persons with hemophilia A.
Morbid Mortal Weekly Rep 1982; 31: 365-7.
8) KesslerCM, Schulof RS, Goldstein AL, Naylor PH,
Luban NLC, Kelleher JF, Reaman GH. Abnormal
T-lymphocyte subpopulations associated with trans-
fusions of blood derived products. Lancet 1983; i:
991-2.
9) Menitove JE, Aster RH, Casper JT, Lauer SJ,
Gottschall JL, Williams J, Gill JE, Wheeler DV,
Piaskowski V, Kirchner P, Montgomery RR. T-
lymphocyte subpopulations in patients with classic
hemophilia treated with cryoprecipitate and lypophi-
lized concentrates. New Engl J Med 1983; 308: 83-6.
10) Goldsmith JC, Moseley PL, Monick M, Brady M,
Hunninghake GW. T-lymphocyte subpopulation