Læknablaðið - 15.08.1986, Blaðsíða 31

LÆKNABLAÐIÐ
169
einstaklingum. Ekki urðu heldur marktækar
breytingar á flúoríðþéttni viðmiðunarhóps-
ins þá daga, sem tilraunin stóð. Ekstrand
o. fl. (8) birta í ritgerð sinni frásogsferil
fenginn eftir töku 1,5 mg af flúoríði í töflum
frá erlendum framleiðanda. Af honum má
ráða að hámarksþéttni, 60-65ng/ml hafi
náðst eftir 45 mínútur og er það mjög sam-
bærilegt við okkar niðurstöður.
SUMMARY
Plasma fluoride concentration in 12 volunteers (dental
students, aged 22-28 years) living in Reykjavik and vi-
cinity was determinded three times during an interval of
eight hours. The mean plasma fluoride concentrations
of each subject ranged from 5.9 ng/ml to 19.9 ng/ml
(fig. 1). For the group as a whole the mean plasma
fluoride concentration was 11.9 ng/ml ± 3.8 S.D.
Considerable fluctuations were seen in the plasma level
in seven of the twelve subjects.
The absorpti.on of fluoride from sodium fluoride ta-
blets of domestic origin (0.25 mg F-/tablet) was also
studied. Peak plasma concentration of fluoride was
obtained in 1 hour and it was back to normal level seven
hours later.
Fluoride in plasma was determinded with a fluoride
selective electrode.
HEIMILDIR
1. Fuchs C, Dorn D, Fuchs CA, Henning HV,
Mclntosh C, Scheler F. Fluoride determination in
plasma by iron selective electrodes: A simplified
method for the clinical laboratory. Clin Clim Acta
1975; 60: 1275-67.
2. Jakob Kristinsson, Þorkell Jóhannesson, Hörður
Þormar. Harðjaxl (bíður birtingar).
3. Henschler D, Buttner W, Patz J. Absorption, dis-
tribution in body fluids and biovailability of fluo-
ride. In: Kuhlencordt F, Kruse H (eds.) Calcium
metabolism, bone and metabolic bone disease.
Berlin : Springer Verlag, 1975: 111-21.
4. Ekstrand J. Relationship between fluoride in the
drinking water and the plasma fluoride concentra-
tion in man. Caries Res 1978; 12: 123-7
5. Guy WS, Taves DR, Brey WS. Organic fluorocom-
pounds in human plasma: prevalance and charac-
terization. In: Filler R (ed.) Biochemistry involving
carbon-fluorine bonds (ACS Symposium Series;
28). Washington: American Chemical Society,
1976: 117-34
6. Hörður Þormar: óbirtar athuganir.
7. Björg Sigurbergsdóttir, Alda Möller: Flúor í íslensk-
um matvælum og flúortekja úr fæði. Reykjavík:
Rannsóknastofnun fiskiðnaðarins, Háskóli íslands,
1984
8. Ekstrand J, Alvan G, Boreus LO, Norlin A.
Pharmacokinetics of fluoride in man after single
and multiple oral doses. Eur J Clin Pharmacol
1977; 12: 311-7