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Læknablaðið - 15.06.2007, Side 16

Læknablaðið - 15.06.2007, Side 16
FRÆÐIGREINAR / LANGVINN LUNGNATEPPA eru margir sem ekki hafa reykt. Hvort um er að ræða einstaklinga sem fyrir áratugum höfðu teppu- sjúkdóm í lungum (til dæmis astma) sem hvorki var greindur eða meðhöndlaður verður ekki skýrt á grunni þessarar þverskurðarrannsóknar. Einnig hefur verið bent á að ef hlutfallið FEVl/FVC <70 er notað fyrir eldri einstaklinga þá leiði það líkleg- ast til ofmats á LLT meðal þeirra (34). Bent hefur verið á aðrar tölfræðilegar aðferðir sem nota mætti við túlkun blástursprófa (36), en ekki hefur náðst samstaða um þær enn. Pessi rannsókn sýnir háa tíðni langvinnrar lungnateppu á íslandi þegar fylgt er alþjóðlega viðurkenndum og samræmdum vísindavinnu- brögðum. Upplýsingarnar munu nýtast yfirvöldum vel til þess að forgangsraða verkefnum í heilbrigð- isþjónustu. Þakkir Höfundar vilja þakka þeim sem þátt tóku í rann- sókninni. Einnig Lovísu Guðmundsdóttur og Sigrúnu Guðmundsdóttur fyrir frábæra aðstoð við framkvæmd og söfnun gagna. Eftirfarandi læknanemum fyrir vinnu við gagnasöfnun: Önnu Björnsdóttur, Guðrúnu Fönn Tómasdóttur, Jóhanni Matthíasi Haukssyni, Martin Inga Sigurðssyni, Óla Hilmari Ólafssyni, Ólöfu Birnu Margrétardóttur, Sigurði James Þorleifssyni og Vöku Ýr Sævarsdóttur. Vísindasjóður Landspítala og lyfjafyrirtækin GlaxoSmithKline og Astra- Zeneca studdu rannsóknina fjárhagslega, en höfðu engin áhrif á framkvæmd, túlkun á niðurstöðum eða skrif. Heimildir 1. Pauwels RA, Buist AS, Calverley PMA, Jenkins CR, Hurd SS. On behalf of the GOLD Scientific Committee, Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. NHLBL/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary. Am J Respir Crit Care Med 2001; 163:1256-1276. www.goldcopd.org 2. Murray CJL, Lopez AD. Alternative Projections of Mortality and Disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997; 349:1498-504. 3. Gulsvik A, Boman G, Dahl R, Gislason T, Nieminen M. The burden of obstructive lung disease in the Nordic countries. Respir Med 2006; 100 Suppl A:S2-9. 4. Jemal A, Ward E, Hao Y, Thun M. Trends in the Leading Causes of Death in the United States, 1970-2002. JAMA 2005; 294:1255-9. 5. Celli BR, Halbert RJ, Isonaka S, Schau B. Population impact of different definitions of airway obstruction. Eur Respir J 2003; 22:268-73. 6. Halbert RJ, Isonaka S, George D, Iqbal A. Interpreting COPD Prevalence Estimates: What is the True Burden of Disease? Chest 2003; 123:1684-92. 7. Celli BR, MacNee W, and committee members. ATS/ERS Task force: Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper. Eur RespirJ 2004; 23:932-46. 8. Mannino DM, Gagnon RC, Petty TL, Lydick E. Obstructive lung disease and low lung function in adults in the United States. Arch Intem Med 2000; 160:1683-89. 9. Fukuchi Y, Nishimura M, Ichinose M, Adachi M, Nagai A, Kuriyama T, et al. COPD in Japan: the Nippon COPD Epidemiology study. Respirology 2004; 9:458-65. 10. Kim DS, Kim YS, Jung KS, Chang JH, Lim CM, Lee JH, et al. Prevalence of Chronic Obstmctive Pulmonary Disease in Korea: A population- based spirometry survey. Am J Respir Crit Care Med 2005; 172:842-7. 11. Pena VS, Miravitlles M, Gabriel R, Jimenez-Ruiz CA, Villasante C, Masa JF, et al. Geographic Variations in Prevalence and Underdiagnosis of COPD: Results of the IBERPOC Multicentre Epidemiological Study. Chest 2000; 118:981-9. 12. Menezes AM, Perez-Padilla R, Jardim JR, Muino A, Lopez MV, Valdivia G, et al. Chronic obstructive pulmonary disease in five Latin American cities (the Platino study): a prevalence study. Lancet 2005; 366:1875-81. 13. Wise RA, Kanner RE, Lindgren P, Connett JE, Altose MD, Enright PL, et al. The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study. Chest 2003; 124:449-58. 14. Gíslason Þ,Tómasson K. Dánartíðni vegna astma, langvinnrar berkjubólgu og lungnaþembu. Læknablaðið 1994; 80:239-43. 15. de Marco R, Accordini S, Cerveri I, Corsico A, Sunyer J, Neukirch F, et al. An international survey of chronic obstructive pulmonary disease in young adults according to GOLD stages. Thorax 2004:59; 120-5. 16. Buist AS, Vollmer WM, Sullivan SD, Weiss KB, Lee TA, Menezes AM, et al. The Burden of obstructive Lung Disease Initiative (BOLD): Rationale and Design. COPD 2005; 2:277- 83. 17. Mannino DM, Doherty DE, Buist AS. Global Initiative on Obstructive Lung Disease (GOLD) classification of lung disease and mortality: findings from the Atherosclerosis Risk in Communities (ARIC) study. Respir Med 2006; 100:115-22. 18. American Thoracic Society Statement: Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995; 152: 1107-36. 19. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric Reference Values from a Sample of the General US Population. Am J Respir Crit Care Med 1999; 159:179-87. 20. Lohr SL. Sampling: Design and Analysis, Duxbury 1999:268- 9. 21. Soriano JB,MaierWC,Egger P,Visick G,Thakrar B,Sykes J,et al. Recent trends in physician diagnosed COPD in women and men in the UK.Thorax 2005;55:789-94. 22. Lundback B, Lindberg A, Lindstrom M, Ronmark E, Jonsson AC, Jonsson E, et al. Not 15 But 50% of smokers develop COPD? - Report from the Obstructive Lung Disease in Northern Sweden Studies. Repir Med 2003; 97:115-22. 23. Chapman KR, Mannino DM, Soriano JB, Vermeire PA, Buist AS, Thun MJ, et al. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J 2006; 27:188-207. 24. Connett JE, Murray RP, Buist AS, Wise RA, Bailey WC, Lindgren PG, et al. Lung Health Study Research Group. Changes in smoking status affect women more than men: Results of the Lung Health Study. Am J Epidemiol 2003; 157: 973-9. 25. Magnússon S, Gíslason T. Chronic bronchitis in Icelandic males and quality of life. Scand J Prim Health Care 1999; 17: 100-4. 26. Benediktsdóttir B, Tómasson K, Gíslason T. Undiagnosed chronic bronchitis among women. Abstract. Nordic Lung Congress. Copenhagen june 10-12,1999. 27. Janson C, Chinn S, Jarvis D, Zock JP, Toren K, Burney P. Effect of passive smoking on respiratory symptoms, bronchial responsiveness, lung function, and total serum IgE in the European Community Respiratory Health Survey: a cross- sectional study. Lancet 2001; 35:2103-9. 28. Kiinzli N, Marco de R, Chinn'S, Jarvis D, Svanes C, Heinrich J, et al. Changes in active and passive smoking in the European Community Respiratory Health Survey. Eur Respir J 2006; 27: 517-24. 29. de Marco R, Accordini S, Cerveri I, Corsico A, Anto JM, Kunzli N, et al. Incidence of COPD in a Cohort of Young Adults According to the Presence of Chronic Cough and Phlegm. Am J Respir Crit Care Med 2007; 175:32-9. 476 Læknablaðið 2007/93

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