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Læknablaðið - 15.02.2009, Blaðsíða 22

Læknablaðið - 15.02.2009, Blaðsíða 22
FRÆÐIGREINAR RANNSÓKNIR 17. Wutzler P, Farber I, Wagenpfeil S, Bisanz H, Tischer A. Seroprevalence of varicella-zoster virus in the German population. Vaccine 2001; 20:121-4. 18. Boelle PY, Hanslik T. Varicella in non-immune persons: incidence, hospitalization and mortality rates. Epidemiol Infect 2002; 129: 599-606. 19. Brisson M, Edmunds WJ, Law B, et al. Epidemiology of varicella zoster virus infection in Canada and the United Kingdom. Epidemiol Infect 2001; 127: 305-14. 20. Chant KG, Sullivan EA, Burgess MA, et al. Varicella-zoster virus infection in Australia.[erratum appears in Aust N Z ] Public Health 1998; 22: 630]. Aust N Z J Public Health 1998; 22: 413-8. 21. Rawson H, Crampin A, Noah N. Deaths from chickenpox in England and Wales 1995-7: analysis of routine mortality data.[see comment]. BMJ 2001; 323:1091-3. 22. Galil K, Brown C, Lin F, Seward J. Hospitalizations for varicella in the United States, 1988 to 1999. Pediatr Infect Dis J 2002; 21: 931-5. 23. Ratner AJ. Varicella-related hospitalizations in the vaccine era. Pediatr Infect Dis J 2002; 21: 927-31. 24. Starko KM, Ray CG, Dominguez LB, Stromberg WL, Woodall DF. Reye's syndrome and salicylate use. Pediatr 1980; 66:859- 64. 25. Kuter B, Matthews H, Shinefield H, et al. Ten year follow-up of healthy children who received one or two injections of varicella vaccine. Pediatr Infect Dis J 2004; 23:132-7. 26. Shehab Z, Brunell PA. Enzyme-linked immunosorbent assay for susceptibility to varicella. J Infect Dis 1983; 148: 472-6. 27. www.hagstofan.is. Mannfjöldi, yfirlit. /ágúst, 2008. 28. Choo PW, Donahue JG, Manson JE, Platt R. The epidemiology of varicella and its complications. J Infect Dis 1995; 172: 706- 12. 29. Jackson MA, Burry VF, Olson LC. Complications of varicella requiring hospitalization in previously healthy children. Pediatr Infect Dis J 1992; 11: 441-5. 30. Ziebold C, von Kries R, Lang R, Weigl J, Schmitt HJ. Severe complications of varicella in previously healthy children in Germany: a 1-year survey.[erratum appears in Pediatr 2004; 113:1470]. Pediatr 2001; 108: E79. 31. Tyrrell GJ, Lovgren M, Kress B, Grimsrud K. Varicella- associated invasive group A streptococcal disease in Alberta, Canada—2000-2002. Clin Infect Dis 2005; 40:1055-7. 32. Balfour HH, Jr. Acyclovir for childhood chickenpox. No reason not to treat. BMJ 1995; 310:109-10. 33. Miron D, Lavi I, Kitov R, Hendler A. Vaccine effectiveness and severity of varicella among previously vaccinated children during outbreaks in day-care centers with low vaccination coverage. Pediatr Infect Dis J 2005; 24: 233-6. 34. Sheffer R, Segal D, Rahamani S, et al. Effectiveness of the Oka/GSK attenuated varicella vaccine for the prevention of chickenpox in clinical practice in Israel. Pediatr Infect Dis J 2005; 24: 434-7. 35. Shinefield H, Black S, Digilio L, et al. Evaluation of a quadrivalent measles, mumps, rubella and varicella vaccine in healthy children. Pediatr Infect Dis J 2005; 24: 665-9. 36. Weibel RE, Neff BJ, Kuter BJ, et al. Live attenuated varicella virus vaccine. Efficacy trial in healthy children. N Engl J Med 1984; 310:1409-15. 37. Knuf M, Habermehl P, Zepp F, et al. Immunogenicity and safety of two doses of tetravalent measles-mumps-rubella- varicella vaccine in healthy children. Pediatr Infect Dis J 2006; 25:12-8. 38. Coudeville L, Paree F, Lebrun T, Sailly J. The value of varicella vaccination in healthy children: cost-benefit analysis of the situation in France. Vaccine 1999; 17:142-51. 39. Law B, Fitzsimon C, Ford-Jones L, McCormick J, Riviere M. Cost of chickenpox in Canada: part II. Cost of complicated cases and total economic impact. The Immunization Monitoring Program-Active (IMPACT). Pediatr 1999; 104: 7-14. >- CC < 2 2 D V) I </> _l o z LU epidemiology and complications Varicella in lcelandic children - Introduction: Varicella is a common disease with possible consequences. The disease is usually contracted in childhood and persistent antibodies are produced. Varicella vaccine is not widely used in lceland. The aim of the study was to investigate the epidemiology of varicella in lcelandic children and it's complications. The results may prove important when deciding on varicella immunization in lceland. Material and methods: The study was retrospective cross sectional. Varicella antibodies were measured from children <18 years of age. Hospital records of children with varicella were evaluated. Results: Serum samples numbered 280. Varicella antibodies were present in 65% of children <1 year of age but in 10% of 1-2 year old children. Almost all children had antibodies before the age of ten and 97.5% of children >10 years had antibodies. Hospital admittions were 58, annual admittions were or 3.6/100.000 children <18 years. Bacterial infections, most frequently skin infections, were the most common complication, followed by cerebellar ataxia, dehydration and nutritional deficiency. Conclusion: Most children in lceland contract varicella before the age of ten. Substantial complications were recorded. It is important to recognize varicella, it’s complications, treatment options and explore whether varicella vaccination should be instigated in lceland. Thorarinsdottir H, Löve A, Laxdal Th, Gudnason Th, Haraldsson A. Varicella in lcelandic children - epidemiology and complications. Icel Med J 2009; 95:113-118. Key words: varícella, epidemiology, complications, children, infants, immunization. Correspondence: Asgeir Haraldsson, asgeir@landspitali.is Barst: 19. september 2008, - samþykkt til birtingar: 16. desember 2008. 1 8 LÆKNAblaðið 2009/95
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