Fróðskaparrit - 31.12.2000, Blaðsíða 51

55
Search for Susceptibility Loci on Selected
Chromosomes in Patients with Mental
Disorders from the Faroe Islands
Leitan eftir ílegumøguleikum á útvaldum kromosomum hjá
føroyskum sjúklingum við sinnisligum sjúkum
Hans A. Dahl3, August G. Wang1,5, Maria Vang1, Ann E. Østerø2, Birthe Degn4,
Ole Mors4, Sofus Joensen1, Mette Nyegaard3, Torben A. Kruse3, Henrik Ewald4
'Department of Psychiatry, National Hospital, Faroe Islands
2Department of Bioanalyses, National Hospital, Faroe Islands
3Department of Clinical Chemistry, Odense University Hospital
4Institute of Basic Psychiatric Research, Risskov, University of Aarhus
5Department of Psychiatry, Amager Hospital, Copenhagen University Hospital
Contact:
August G. Wang, Dr. Med. Sci., Dep. of Psychiatry, Amager Hospital. Øster Farimagsgade 5, DK-1399
Copenhagen K, Denmark., Tel: +45 33383920. Fax: +45 33383719. E-mail: agwang@get2net.dk
Úrtak
Kring allan heim verður roynt at koma nærri møguligum
ílegum, sum kunnu hava týdning fyri eitt nú sinnisligar
sjúkur. Tey seinastu árini hevur áhugin serstakliga vent
sær ímóti kanningum millum fólk í útjaðaraøkjum, har
frávik í flegum kunnu vera í færri útgávum og tí lættari
at finna. í hesum føri er kanningarøkið Føroyar.
Sum liður í heildarkanning við atliti at fleguøki, sum
hevur við tvípólasjúku, skisofreni og panikksjúku at
gera, kunnu vit her vísa á úrslit, ið peika á nøkur øki,
sum eru verd at kanna nærri (sí talvu 1).
Kanningin hevur allar góðkenningar og er ikki hand-
ilslig. Men kemur ein inn at eini ítøkiligari flegu, verður
spurningurin, um hetta skal almannakunngerast beinan-
vegin fyri at sleppa undan einkarrætti, ella tvørturímóti.
Abstract
Around the world, scientists are trying to identify chro-
mosomal regions that possibly contain genes involved
in mental disorders. To some extent, genetically isolat-
ed populations are used for such studies, based on the
assumption that locus heterogeneity is lower in isolated
populations. A reduction in genetic and environmental
heterogeneity may increase the likelihood of detecting a
disease-bearing locus. For the search of susceptibility
genes, we have chosen the Faroe Islands, which, both
historically and geographically, seems ideal for such ge-
netic studies.
A full genome screening was performed, searching
for areas that could be of interest in relation to bipolar
illness, schizophrenia, and panic disorder. From the on-
going screening, our results point to some areas of the
genome that are of interest for further studies, Table 1.
This study has been accepted on legal and ethical
terms. However, if an illness-related gene locus is iden-
tified, patenting versus publishing issues will need to be
resolved.
Fróðskaparrit 48. bók 2001: 55-60