Læknablaðið - 01.04.1974, Qupperneq 29

LÆKNABLAÐIÐ
77
Þegar haft er í huga, að stór hluti
primær heilamengisblæðinga orsakast af
því að æðagúll hefur sprungið og að tíðni
primær heilamengisblæðinga hérlendis er
■8.0/100.000 íbúa á ári,7 virðast líkurnar
fyrir ættgengni óverulegar.
Ekki hefur okkur tekist að sýna fram
á skyldleika þessarar fjölskyldu við heila-
blæðingaættir.8
ÁGRIP
Gerð er grein fyrir þrem ættingjum, föð-
ur og tveim dætrum hans (mynd 5), með
heilaæðagúl. í tveim tilfellum hafði gúll-
inn sprungið og sjúklingarnir verið skorn-
ir upp. Tveir sjúklinganna höfðu fleiri en
einn æðagúl. Aðgerðir á sjúklingunum
voru gerðar í heilaskurðdeild Ríkisspítal-
ans í Kaupmannahöfn (yfirlæknir próf.
John Riishede).
HEIMILDIR
1. Adams, Raymond, D., Lidnam, Richard, L.
Introduction to Neuropathology. McGraw
-Hill Book Company. New York, Toronto,
Sydney, London. 1968.
2. Beumont, P. J. V. The familial occurrence
of berry aneurysm J. Neurol. Neurosurg.
Psychiat. 31:399-402. 1968.
3. Chakravorty, Benov G. and Gleadhill,
Colin A. The Incidence of Cerebral Aneur-
ysms. Brit. Med. J. 1:147-148. 1966.
4. Chambers, W. R., Harper, B. F. jr. and
Simpson, J. R. Familial incidence of con-
genital aneurysms of cerebral arteries. Re-
port of cases of ruptured aneurysms in
father and son. J.A.M.A. 155:358. 1954.
5. Dietlefsen, Else Marie Lindseth and Töni-
um, A. M. Intracranial Aneurysms and
Polycystic Kidneys. Acta Medica Scand.
Vol. 168, fasc 1. (51-54). 1960.
6. Forbus, W. D. (1930): Cit. Pakarinen, S.
7. Gunnar Guðmundsson. Primary Subarach-
noid hæmorrhagi in Iceland. Stroke 4:764-
767. 1973.
8. Guðmundsson, G., Hallgrímsson, J„ Jónas-
son, T. Á. et al. Hereditary cerebral haem-
orrhage with amyloidosis. Brain 95:387-404.
1972.
9. Pakarinen, S. Incidence, etiology and pro-
gnosis of primary subarachnoid haemorr-
hage. A study based on 589 cases diagnosed
in a defined urban population during a de-
fined period. Acta Neurol. Scand. (Suppl.
29) 43:1-128. 1967.
10. Pratt, R. T. C. The Genetics of Neurological
Disorders, p. 123. Oxford University Press.
London 1967.
11. Sarner, Martin and Crawford, Margaret, D.
Ruptured intracranial aneurysm. Clinical
series. Lancet 11:1251-1254. 1965.
12. Vijay K. Kak, Colin A. Gleadhill and Ian
C. Bailey. The familial incidence of intra-
cranial aneurysms. J. Neurol. Neurosurg.
Psychiat. 33:29-33. 1970.
13. Walton, J. N. Subarachnoid Haemorrhage.
E. S. Livingstone Ltd., Edinburgh and Lon-
don.
SUMMARY
A familial incidence of congenital aneurysms
of cerebral arteries. Report of cases of father
and two daughters.
During the period 1967 to 1973 or from the
opening of the Neurological department, Land-
spítalinn (the only neurological department in
Iceland), 68 patients were diagnosed as having
cerebral aneurysm. Of these three were near
relatives (or 4.4%), father (aged 39) and two
of his daughters (aged 21). This paper des-
cribes the history and progress of these three
patients. In two of them the aneurysm had
bled, but not in propositus. The pedigree shows
that four near relatives had died from “cere-
bral haemorrhage” (I 1 and 2, II 2 and 3). One
of the siblings IV 3, age 17, has Klippel-Feil
syndrome and a systolic murmur over t he
heart base, and has probably had one grand
mal attack. Another sibling IV 5, age 10, has
been investigated for suspected vascular ano-
maly of left arm.
Migraine amongst near relatives is said to
be common. The patients III, 1 and IV, 1,
were operated in the neurosurgical depart-
ment Rigshospitalet, Copenhagen (Chief, prof.
J. Riishede).