Læknablaðið - 15.05.1992, Side 54

208
LÆKNABLAÐIÐ 1992; 78: 208-9
NÝR DOKTOR í LÆKNISFRÆÐI -
BÁRÐUR SIGURGEIRSSON
Þann 16. janúar síðastliðinn lauk Bárður
Sigurgeirsson lœknir doktorspróf frá
Karólínska sjúkrahúsinu í Stokkhólmi.
Ritgerðin heitir á frummálinu: »Skin Disease
and Malignancy. An Epidemiological Study.«
Hér á eftir fer útdráttur i'ir ritgerðinni:
The aim of this work was to develop a
computer program (CANEST) to estimate
the risk of cancer in patient populations and
to use this program to investigate cancer
risk associated with several dermatological
disorders. Patients seen at the dermatology
departments at the Karolinska Hospital and
South Hospital were used for the study of
chronic urticaria, condylomata acuminata,
basal cell carcinoma, lichen planus and
positive patch tests. The national Swedish
In-Patient Register was used to lind all
patients hospitalized for dermatomyositis or
polymyositis since 1964. From eleven large
dermatological centers in Sweden, details of
close to 5,000 PUVA-treated patients were
obtained for study.
The computer program CANEST was
developed and used to calculate the expected
number of malignant tumors in these patient
populations, based on incidence data from
the Swedish Cancer Register for the years
1958-1987. By matching the patients’ records
with the Cancer Register the actual number of
cancers was obtained.
Of 1,155 patients with chronic urticaria, a
malignancy was diagnosed in 36, while the
expected number was 41: clearly there is
therefore no association between chronic
urticaria and malignancy.
In 3,260 patients with condylomata acuminata
there was no increased risk of cancer in
situ of the cervix (relative risk=l .5; 95%
confidence interval 0.9 to 2.5) and the number
of genitourinary cancers in males was almost
three times higher than expected (2.6; 1.2 to
5.0). These results indicate that the risk of
developing cervical carcinoma in situ is less
than previously thought, but the implications
of the increase in genitourinary tumors in
males are uncertain.
Patients with basal cell carcinoma had an
increased risk of malignancy in general.
Melanoma risk was seven times greater in
males (6.6; 3.0 to 12.5) after the basal cell
carcinoina diagnosis. Risks of squamous cell
carcinoma of the skin, lung cancer, thyroid
cancer and cancer of the uterine cervix were
also increased.
No increased risk of cutaneous malignancy
was found in 2,071 patients with lichen
planus, but for oral cancer it was six times
greater in males (5.9; 2.5 to 11.4).
A slight general increase in malignancy risk
was found in 2,183 males (1.3; 1.1 to 1.5)