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Læknablaðið - 15.01.2012, Qupperneq 30

Læknablaðið - 15.01.2012, Qupperneq 30
RANNSÓKN Heimildir 1. Habib G, Hoen B, Tornos P, Thuny F, Prendergast B, Vilacosta I, et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Hndocarditis of the European Society of Cardiology (ESC). Eur Heart J 2009; 30:2369-413. 2. Eiriksson H, Thorgeirsson G, Thorsteinsson SB. Hjartaþelsbólga á íslandi 1976-1989. Læknablaðið 1989:75; 149-55. 3. Osler W. The Gulstonian Lectures, on Malignant Endocarditis. Br Med J1885; 1:577-9. 4. Hoen B, Alla F, Selton-Suty C, Béguinot I, Bouvet A, Briangon S, et al. Changing profile of infective endocarditis: results of a 1-year survey in France. JAMA 2002; 288: 75-81. 5. Habib G, Thuny F, Avierinos JF. Prosthetic valve endocarditis: current approach and therapeutic options. Progr Cardiovasc Dis 2008; 50: 274-81. 6. Murdoch DR, Corey GR, Hoen B, Miró JM, Fowler VG Jr, Bayer AS, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intem Med 2009; 169:463-73. 7. Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG Jr, Ryan T, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000; 30: 633-8. 8. Tleyjeh IM, Abdel-Latif A, Rahbi H, Scott CG, Bailey KR, Steckelberg JM, et al. A systematic review of population-based studies of infective endocarditis. Chest 2007; 132:1025-35. 9. Bouza E, Menasalvas A, Munoz P, Vasallo FJ, del Mar Moreno M, Garcia Femandez M A. Infective endocarditis--a prospective study at the end of the twentieth century: new predisposing conditions, new etiologic agents, and still a high mortality. Medicine (Baltimore) 2001; 80:298-307. 10. Silverman ME, Upshaw CB Jr. Extracardiac manifestations of infective endocarditis and their historical descriptions. Am J Cardiol 2007; 100:1802-7. 11. Loupa C, Mavroidi N, Boutsikakis I, Paniara O, Deligarou O, Manoli H, et al. Infective endocarditis in Greece: a changing profile. Epidemiological, microbiological and therapeutic data. Clin Microbiol Infect 2004; 10:556-61. 12. Wang A, Athan E, Pappas PA, Fowler VG Jr, Olaison L, Paré Cet al. Contemporary clinical profile and outcome of prosthetic valve endocarditis. JAMA 2007; 297:1354-61. 13. Cabell CH, Jollis JG, Peterson GE, Corey GR, Anderson DJ, Sexton DJ, et al. Changing patient characteristics and the effect on mortality in endocarditis. Arch Int Med 2002; 162: 90-4. 14. Moreillon P, Que YA. Infective endocarditis. Lancet 2004; 363:139-49. 15. Prendergast BD, Tomos P. Surgery for infective endocarditis: who and when? Circulation 2010; 121: 1141- 52. ENGLISH SUMMARY Endocarditis in lceland 2000-2009, a national survey incidence, microbiology and prognosis Tryggvadottir EB', Agnarsson UT’ 2, Sverrisson JT3, Thorsteinsson SB2, Högnason JV2 Thorgeirsson G2 Introduction: The objective of this study was to analyze the incidence, clinical features, microbiology and prognosis of patients with infective endocarditis (IE) in lceland, and to compare the results with a previous study made in lceland 1976-85. Material and Methods: A retrospective study including all patients diagnosed with IE in lceland 2000-2009. Information was obtained from medical records. Results: A total of 88 cases (71 % men, mean age 59 years) were diagno- sed and the incidence of IE was calculated 2.97/100.000 person-years. The mitral valve was infected in 35 patients (40%), aortic in 27 (31%) and tricuspid in 9 (10%). In 19 cases a prosthetic valve was infected (22%), one early (<60 days from procedure) and 18 late. Sixteen patients were intravenous drug users. The most common causative organisms were streptococcus (33%), staphylococcus (25%) and enterococcus (16%). Surgical intervention was performed in 16 cases (18%). One and five year survival was 77% and 57% respectively. Conclusion: The incidence of IE in lceland is still low compared to other countries. The clinical profile of the disease has changed since 1976- 85, patients with prosthetic heart valves and intravenous drug users were more prominent than before. The microbiological spectrum has not changed much, streptococcus is still the most common pathogen, contrary to what is seen in other industrial countries where S. aureus is more frequent. Death rate is lower than before and one year survival good compared to other reports. Key words: Endocarditis, heart valve, prosthetic valve, iv. drug use, vaive replacement surgery, incidence, survival. Correspondence: Elin Björk Tryggvadóttir, ebtVShi.is 'Faculty of Medicine, 2University of lceland, Reykjavik, lceland, "Akureyri Hospital, Akureyri, lceland. 30 LÆKNAblaöið 2012/98
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