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Læknablaðið - feb. 2019, Blaðsíða 18

Læknablaðið - feb. 2019, Blaðsíða 18
70 LÆKNAblaðið 2019/105 R A N N S Ó K N 1. Steere AC, Malawista SE, Snydman DR, Shope RE, Andiman WA, Ross MR, et al. Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Arthritis Rheum 1977; 20: 7-17. 2. Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP. Lyme disease-a tick-borne spirochetosis? Science 1982; 216: 1317-9. 3. Stanek G, Wormser GP, Gray J, Strle F. Lyme borreliosis. Lancet 2012; 379: 461-73. 4. Steere AC. Lyme Disease. N Engl J Med 2001; 345: 115-25. 5. Mannelli A, Bertolotti L, Gern L, Gray J. Ecology of Borrelia burgdorferi sensu lato in Europe: transmission dynamics in multi-host systems, influence of molecular processes and effects of climate change. FEMS Microbiol Rev 2011; 36: 837-61. 6. Dessau RB, Bangsborg JM, Hansen K, Lebech AM, Sellebjerg F, Skarphedinsson S, et al. Lyme Borreliosis: Klinik, diagnostik og behandling i Danmark. dskm.dk - Klinisk Vejledning 2014: 50. 7. Wilhelmsson P, Lindblom P, Fryland L, Ernerudh J, Forsberg P, Lindgren PE. Prevalence, Diversity, and Load of Borrelia species in Ticks That Have Fed on Humans in Regions of Sweden and Åland Islands, Finland with Different Lyme Borreliosis Incidences. PLoS ONE 2013; 8: e81433. 8. Hengge UR, Tannapfel A, Tyring SK, Raimund E, Arendt G, Ruzicka T. Lyme Borreliosis. Lancet Infect Dis 2003; 3: 489-500. 9. Randolph SE. The shifting landscape of tick-borne zoonoses: tick-borne encephalitis and Lyme borreliosis in Europe. Phil Trans R Soc Lond 2001; 356: 1045-56. 10. Centers for Disease Control and Prevention. How many people get Lyme disease? cdc.gov/lyme/stats/humancases. html - febrúar 2018. 11. Schwarz AM, Hinckley AF, Mead PS, Hook SA, Kugeler KJ. Surveillance for Lyme Disease - United States, 2008- 2015. MMWR 2017; 66: 1-12. 12. Rizzoli A, Hauffe HC, Carpi G, Vourc‘h GI, Neteler M, Rosa R. Lyme borreliosis in Europe. Euro Surveill 2011; 16: pii=19906. 13. Sood SK, Salzman MB, Johnson BJB, Happ CM, Feig K, Carmody L, et al. Duration of Tick Attachment as a Predictor of the Risk of Lyme Disease in an Area in which Lyme Disease Is Endemic. J Infect Dis 1997; 175: 996-9. 14. Stanek G, Fingerle V, Hunfeld KP, Jaulhac B, Kaiser R, Krause A, et al. Lyme borreliosis: Clinical case definitions for diagnosis and management in Europe. Clin Microbiol Infect 2011; 17: 69-79. 15. Skogman BH, Ekerfelt C, Ludvigsson J, Forsberg P. Seroprevalence of Borrelia IgG antibodies among young Swedish children in relation to reported tick bites, symptoms and previous treatment for Lyme borreliosis: a population-based survey. Arch Dis Child 2010; 95: 1013-6. 16. Brouqui P, Bacellar F, Baranton G, Birtles RJ, Bjoersdorff A, Blanco JR, et al. Guidelines for the diagnosis of tick- -borne bacterial diseases in Europe. Clin Microbiol Infect 2004; 10: 1108-32. 17. Aguero-Rosenfeld ME, Wang G, Schwarz I, Wormser GP. Diagnosis of Lyme Borreliosis. Clin Microbiol Rev 2005; 18: 484-509. 18. Wormser GP, Raymond J, Dattwyler J, Shapiro D, Halperin J, Steere AC, et al. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmonsis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006; 43: 1089-134. 19. Läkemedelsverket. Läkemedelsbehandling av borrelia- infektion - ny rekommendation. Information från Läkemedelsverket 2009; 20: 12-17. 20. Gray JS, Dautel H, Estrada-Pena A, Kahl O, Lindgren E. Effects of Climate Change on Ticks and Tick-Borne Diseases in Europe. Interdiscip Perspect Infect Dis 2009; 2009: 593232. 21. Bennet L, Halling A, Berglund J. Increased incidence of Lyme borreliosis in southern Sweden following mild winters and during warm, humid summers. Eur J Clin Microbiol Infect Dis 2006; 25: 426-32. 22. Richter SH, Eydal M, Skirnisson K, Olafsson E. Tick species (Ixodida) identified in Iceland. Icel Agric Sci 2013; 26: 3-10. 23. Hasle G, Bjune GA, Midthjell L, Roed KH, Leinaas HP. Transport of Ixodes ricinus infected with Borrelia species to Norway by northward-migrating passerine birds. Ticks Tick Borne Dis 2011; 2: 37-43. 24. Alfredsson M, Olafsson E, Eydal M, Unnsteinsdottir ER, Hansford K, Wint W, et al. Surveillance of Ixodes ricinus ticks (Acari: Ixodidae) in Iceland. Parasit Vectors 2017; 10: 466. 25. Duneau D, Boulinier T, Gomez-Diaz E, Petersen A, Tveraa T, Barrett RT, et al. Prevalence and diversity of Lyme borreliosis bacteria in marine birds. Infect Genet Evol 2008; 8: 352-9. 26. Munoz-Leal S, Gonzalez-Acuna D. The tick Ixodes uriae (Acari: Ixodidae): Hosts, geographical distribution, and vector roles. Ticks Tick Borne Dis 2015; 6: 843-68. 27. Sigurðsson JR, Guðnason Þ, Kristinsson JR, Haraldsson Á. Íslenskur drengur með Lyme-sjúkdóm: sjúkratilfelli og umfjöllun. Læknablaðið 1999; 85: 414-9. 28. Sigurðsson MI, Guðnason Þ, Þorgrímsson S. Tilfelli mánaðarins - Ungur drengur með undarleg útbrot. Læknablaðið 2011; 97: 35-6. 29. MVZ Labor PD Dr. Volkmann und Kollegen. Borrelia burgdorferi antikörper. http://www.laborvolkmann.de/ analysenspektrum/PDF/borrelia-burgdorferi-antikoerper. pdf - júlí 2018. 30. Lantos PM, Branda JA, Boggan JC, Chudgar SM, Wilson EA, Ruffin F, et al. Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence. Clin Infect Dis 2015; 61: 1374-80. 31. Dessau RB, van Dam AP, Fingerle V, Gray J, Hovius JW, Hunfeld KP, et al. To test or not to test? Laboratory supp- ort for the diagnosis of Lyme borreliosis: a position paper of ESGBOR, the ESCMID study group for Lyme borrelios- is. Clin Microbiol Infect 2018; 24: 118-24. Heimildir Barst til blaðsins 5. nóvember 2018, samþykkt til birtingar 2. janúar 2019. Hannes Bjarki Vigfússon1 Hörður Snævar Harðarson1,2 Björn Rúnar Lúðvíksson3,4 Ólafur Guðlaugsson5 Introduction: Lyme disease is caused by an infection with Borrelia burgdorferi sensu latu (B. burgdorferi sl.) which is carried by Ixodes ticks. The disease has not been considered to be endemic in Iceland and no cases of Icelandic origin have been published. The epidemiology of Lyme disease in Iceland has never been studied. The objective of this study was to provide basic epidemiological information about Lyme disease in Iceland. Material and methods: Included in the study were all pa - tients who had a measurement of serum antibodies against B. burgdorferi sl. or were diagnosed with Lyme disease (ICD-10, A69.2) at Landspítali University Hospital in Iceland from 2011- 2015. Clinical data regarding these patients was retrospectively collected from medical records and the database of the Depart- ment of clinical microbiology at Landspítali University Hospital. Results: 501 patient had a measurement of serum antibodies against B. burgdorferi sl. and 11 patients were clinically diag- nosed with Lyme disease during the study period. 33 patients fulfilled criteria for a confirmed diagnosis of Lyme disease. 32 (97%) patients had erythema migrans and one (3%) patient had neuroborreliosis. An average of 6.6 cases were diagnosed a year (two cases per 100,000 persons/year). All cases originated abroad. Conclusions: Lyme disease is rare in Iceland. On average around 6 to 7 cases are diagnosed every year, primarily localised infec- tions presenting as erythema migrans. None of the cases had a definitive Icelandic origin and the yearly number of cases has not been increasing. Lyme disease in Iceland - Epidemiology from 2011 to 2015 ENGLISH SUMMARY Department of clinical microbiology, Landspítali University Hospital, 2Department of paediatrics, Landspítali University Hospital, 3Department of immunology, Landspítali University Hospital, 4Faculty of medicine, University of Iceland, 5Department of infectious diseases, Landspítali University Hospital. Key words: Lyme disease, Borrelia, Borreliosis, epidemiology, Iceland. Correspondence: Ólafur Guðlaugsson, olafgudl@landspitali.is

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