Fróðskaparrit - 31.12.2000, Page 55

Fróðskaparrit - 31.12.2000, Page 55
LEITAN EFTIRILEGUMØGULEIKUM A UTVALDUM KROMOSOMUM HJA FØROYSKUM SJUKLINGUM Vlð SINNISLIGUM SJUKUM 59 possible disease-related area (van der Meulen and Meerman, 1997). So far, interesting areas, but no genes have been identified. The area around 18q23, in bipolar affective disorder, looks especially promising, as another group has reported this area previously in a different population (Freimer et al., 1996). The study presented here is non-com- mercial. However, if one or more areas prove to be the focus of a search for a pos- sible disease-related gene, the question will arise as to whether or not this finding is to be patented or published. Publishing will preclude patenting. In an ever more com- mercialised area of research, the latter course may be challenged (Rifkin, 1998). At present, there is no Faroese legislation on these matters. Ethics The study has been accepted by the Faroese Board for Ethics in Medical Research and the Faroese Board for Registration. The study is non-commercial and funded by public and private grants. Acknowledgements The project has been supported with grants from: the Ministry of Education, Culture, and Research, the Faroese Government (recommendation by the Faroese Research Council); The Danish Research Councils; The Lundbeck Foundation (Grants No. 39/98 and 59/99); the Danish Hospital Foundation for Medical Research, region for Copenhagen, Faroe Islands, and Green- land; the Research Fund of Føroya Sparikassi. References Amason, E., Sigurgislason, H. and Benedikz, E. 2000. Genetic homogeneity of Icelanders, fact or fiction? Nature Genetics 25,4: 37737. á Steig. B., Juin. J.A. and Bull, L.N. 1999. Recidiv- erende familiær intrahepatisk kolestase pá Færøerne. Ugeskr Laeger. 131 (35): 4871-4873. de la Chapelle, A. 1993. Disease gene mapping in iso- lated human populations: the example of Finland. J Med Genet. 30: 857-865. Degn, B., Wang, A.G., Vang, M., Kruse, T.A. and Ewald, H. 1998. Search for susceptibility loci on se- lected chromosomes including a dinucleotide repeat polymorphism at the CCKBR locus in patients with panic disorder from the Faroe Islands. American Joumal ofMedical Genetics (Neuropsychiatric Ge- netics). 81: 486-487. Sixth World Congress on Psy- chiatric Genetics, Bonn, Germany, October 1998. Eaves, I.A., Merriman, T.R., Barber, R.A., Nutland, S., Tuomilehto-Wolf, E., Tuomilehto, J., Cucca, F. and Todd, J.A. 2000. The genetically isolated popula- tions of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common dis- ease genes. Nature Genetics 25: 320-323. Eđitorial. 1998. Mining a rich seam of genetic diversity. Nature 396,6709: 304. Edwards, J.H. 1999. Unifactoral models are not appro- priate for multifactoral disease. British Medical Joumal. 15 May: 318: 1353. Ewald, H., Flint, T., Degn, B., Wang, A.G., Vang, M., Mors, O. and Kruse, T.A. 1999a. A search for a shared segment of chromosome lOq in patients with bipolar affective disorder from the Faroe Islands. Molecular Psychiatry 4; Suppl.l: 72. Ewald, H., Nyegaard, M., Wang, A.G., Vang, M., Mors, O. and Kruse, T.A. 1998. A search for a shared seg- ment of chromosome 18 in patients with bipolar af- fective disorder from the Faroe Islands. American Journal ofMedical Genetics (Neuropsychiatric Ge- netics) 81: 541. Sixth World Congress on Psychi- atric Genetics, Bonn, Germany, October 1998. Ewald, H., Flint, T„ Wang, A.G., Vang, M., Mors, O. and Kruse, T.A. 2000. Evidence for a shared Haplo- type on Chromosome 10q26 in Patients with Bipo- lar Affective Disorder on the Faroe Islands. Ameri- can Journal of Medical Genetics. Neuropsychiatric Genetics. 96,4: 545. Ewald, H., Wang, A.G., Vang, M., Mors, O., Nyegaard, M. and Kruse, T.A. 1997. A Haplotype Study of Lithium Responding Patients with Bipolar Affective Disorder on the Faroe Islands. American Journal of
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