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Læknablaðið - 01.04.2015, Blaðsíða 24

Læknablaðið - 01.04.2015, Blaðsíða 24
208 LÆKNAblaðið 2015/101 R A N N S Ó K N Heimildir 1. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. American Psychiatric Association, Arlington VA 2013. 2. Vgontzas AN, Liao D, Bixler EO, Chrousos GP, Vela- Bueno A. Insomnia with objective short sleep duration is associated with a high risk for hypertension. Sleep 2009; 32: 491-7. 3. Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010; 33: 585-92. 4. Vgontzas AN, Liao D, Pejovic S, Calhoun S, Karataraki M, Basta M, et al. Insomnia with short sleep duration and mortality: the Penn State cohort. Sleep 2010; 33: 1159-64. 5. Stoller MK. Economic effects of insomnia. Clin Ther 1994; 16: 873-97. 6. Rosekind MR, Gregory KB. Insomnia risks and costs: health, safety, and quality of life. Am J Manag Care 2010; 16: 617-26. 7. Daley M, Morin CM, LeBlanc M, Grégoire JP, Savard J. The economic burden of insomnia: direct and indirect costs for individuals with insomnia syndrome, insomnia symptoms, and good sleepers. Sleep 2009; 32: 55-64. 8. Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia. Technology appraisal 77. National Institute for Clinical Excellence, London 2004. nice.org.uk/nicemedia/ live/11530/32845/32845.pdf – júní 2014. 9. Chambless DL, Hollon SD. Defining empirically suppor- ted therapies. J Consult Clin Psychol 1998; 66: 7-18. 10. Morin CM, Culbert JP, Schwartz SM. Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy. Am J Psychiatry 1994; 151: 1172-80. 11. Edinger J, Wohlgemuth W, Radtke R, Marsh G, Quillian R. Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial. JAMA 2001; 285: 1856-64. 12. Marcussen JM (Ed.). Health statistics for the Nordic countries 2013. Nordic Medico-Statistical Committee, Copenhagen 2013. nowbase.org/~/media/Projekt%20sites/ Nowbase/Publikationer/Helse/Health%20Statistics%20 2013.ashx - júní 2014. 13. Kripke DF. Chronic hypnotic use: deadly risks, doubtful benefit. Sleep Med Rev 2000; 4: 5-20. 14. Sivertsen B, Omvik S, Pallesen S, Bjorvatn B, Havik OE, Kvale G, et al. Cognitive behavioral therapy vs. zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA 2006; 295: 2851-8. 15. Edinger JD, Carney, CE. Overcoming insomnia: A cogni- tive-behavioral therapy approach-therapist guide. Oxford University Press, Inc., New York 2008. 16. Morin CM. Cognitive-behavioral approaches to the treatment of insomnia. J Clin Psychiatry 2004; 65: 33-40. 17. Morin CM, Colecchi C, Stone J, Sood R, Brink D. Behavioral and pharmacological therapies for late-life insomnia: A randomized controlled trial. JAMA 1999; 281: 991-9. 18. Lög um sjúkratryggingar. althingi.is/lagas/nuna/2008112. html – júní 2014. 19. Edinger JD, Means MK. Cognitive-behavioral therapy for primary insomnia. Clin Psychol Rev 2005; 25: 539-58. 20. Biering P. Þjónusta og þjónustuþarfir geðfatlaðra í dreifbýli á Íslandi. Rauði kross Íslands, Reykjavík 2005. raudikrossinn.is/redcross/upload/files/pdf/thjonustu- tharfir_dreifbyli.pdf – janúar 2015. 21. Ritterband LM, Thorndike FP, Gonder-Frederick LA, Magee JC, Bailey ET, Saylor DK. Efficacy of Internet-based behavioral intervention for adults with insomnia. Arch Gen Psychiatry 2009; 66: 692-8. 22. Strom L, Pettersson R, Andersson G. Internet-based treatment for insomnia: a controlled evaluation. J Consult Clin Psychol 2004; 72: 113-20. 23. Vincent N, Lewycky S. Logging on for better sleep: RCT of the effectiveness of online treatment for insomnia. Sleep 2009; 32: 807-15. 24. Ritterband LM, Bailey ET, Thorndike FP, Lord HR, Farrell- Carnahan L, Baum LD. Initial evaluation of an Internet intervention to improve the sleep of cancer survivors with insomnia. Psychooncology 2011; 21: 695-705. 25. Lancee J, van den Bout J, van Straten A, Spoormaker VI. Internet-delivered or mailed self-help treatment for insomnia? A randomized waiting-list controlled trial. Behav Res Ther 2011; 50: 22-9. 26. Espie CA, Kyle SD, Williams C, Ong JC, Douglas NJ, Hames P, et al. A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web app- lication. Sleep 2012; 35: 769-81. 27. Bastien CH, Morin CM, Ouellet MC, Blais FC, Bouchard S. Cognitive-behavioral therapy for insomnia: Comparison of individual therapy, group therapy, and telephone consultations. J Consult Clin Psychol 2004; 72: 653-9. 28. Diagnostic and Statistical Manual of Mental Disorders. 4th ed., text revision. American Psychiatric Association, Washington DC 2000. 29. Perlis ML, Jungquist C, Smith MT, Posner D. Cognitive Behavioral Treatment of Insomnia: A Session-by-Session Guide. Springer, New York 2005. 30. Lichstein KL, Durrence HH, Taylor DJ, Bush AJ, Riedel BW. Quantitative criteria for insomnia. Behav Res Ther 2003; 41: 427-45. 31. Van Straten A, Cuijpers P. Self-help therapy for insomnia: a meta-analysis. Sleep Med Rev 2009; 13: 61-71. 32. Espie CA, Inglis SJ, Tessier S, Harvey L. The clinical effec- tiveness of cognitive behaviour therapy in the treatment of chronic insomnia: implementation and evaluation of a sleep clinic in general medical practice. Behav Res Ther 2001; 39: 45-60. 33. Carney C, Buysse DJ, Ancoli-Israel S, Edinger JD, Krystal AD, Lichstein KL, et al. The consensus sleep diary: stand- ardizing prospective sleep self-monitoring. Sleep 2012; 35: 287-302. 34. Sateia MJ, Doghramji K, Hauri PJ, Morin CM. Evaluation of chronic insomnia. Sleep 2000; 23: 243-63. 35. Morin CM, Bastien C, Savard J. Current status of cognitive–behavior therapy for insomnia: Evidence for treatment effectiveness and feasibility. In: Perlis ML, Lichstein KL, eds. Treating sleep disorders: Principles and practice of behavioral sleep medicine. John Wiley & Sons, New York 2003: 262-85. ENgLISH SUMMArY introduction: Insomnia is a common health problem with serious men- tal and physical consequences as well as increased economical costs. The use of hypnotics in Iceland is immense in spite of cognitive behavio- ral therapy for insomnia (CBT-I) being recommended as the first choice treatment of chronic insomnia. To meet the needs of more individuals suffering from insomnia, online CBT-I was established at betrisvefn.is. The objective of this research was to evaluate the effectiveness of this internet-based CBT-I. Material and methods: one hundred seventy-five users (mean age 46y (18-79y)) started a 6 week online intervention for insomnia. The drop- out rate was 29%, leaving a final sample of 125 users. The intervention is based on well-established face-to-face CBT-I. Sleep diaries were used to determine changes in sleep efficiency, sleep onset latency and wake after sleep onset. Treatment effects were assesed after 6 weeks of treatment and at the 6 week follow-up. Results: Significant improvement was found in all main sleep variables except for 5% decrease in total sleep time (TST). Effects were sustained at 6 week follow-up and TST increased. The use of hypnotics decreased significantly. This form of treatment seems to suit its users very well and over 94% would recommend the treatment. Conclusion: Internet interventions for insomnia seem to have good potential. CBT-I will hopefully be offered as the first line treatment for chronic insomnia in Iceland instead of hypnotics as the availability of the CBT-I is growing. Thus, the burden on health care clinics might reduce along with the hypnotics use and the considerable costs of insomnia. Effectiveness of an online cognitive behavioral therapy for insomnia Gudlaug Fridgeirsdóttir1, Steindor oddur Ellertsson2, Gunnar johannsson3, Erla Björnsdottir1,4 1University of Iceland, 2Primary Health Care of the Capital Area, 3Health Care Institution of the Westman Islands, 4The National University Hospital of Iceland. key words: insomnia online CBT Internet treatment sleep. Correspondence: Guðlaug Friðgeirsdóttir, guf11@hi.is 1) Brintellix (vortioxetín) samantekt á eiginleikum lyfsins, sjá www.serlyfjaskra.is. 2) Katona C et al. Int Clin Psychopharmacol. 2012; 27(4): 215-223. 3) McIntyre RS et al. Int. J. Neuropsychopharmacology 2014 doi:10. 1017/S1461145714000546. 4) Alvarez E et al. Int J Neuropsychopharmacol. 2012; 15(15): 589-600. 5) Baldwin DS et al. Eur Neuropsychopharmacol. 2012; 22(7): 482-491. 6) Boulenger JP et al. J Psychopharmacol. 2012; 26(11): 1408-1416. IS -B R IN -2 01 4. 11 -0 00 01 50 4 Brintellix® (vortioxetín) – nýtt þunglyndislyf með fjölþætta verkun til meðferðar á alvarlegum þunglyndisköstum hjá fullorðnum1 Verkunarháttur1 Brintellix (vortioxetín) er nýtt þunglyndislyf með fjölþætta verkun. Verkun1 Verkun Brintellix (vortioxetín) hefur verið rannsökuð samkvæmt klínískri áætlun með fleiri en 6.700 sjúklingum. Vitsmunaleg færni2,3 Brintellix (vortioxetín) bætir vitsmunalega færni marktækt samanborið við lyfleysu hjá sjúklingum með alvarlegt þunglyndi (MDD). Þolanleiki1,4,5,6 Brintellix (vortioxetín) þolist vel. Skammtar1 Upphafs- og viðhaldsskammtur Brintellix (vortioxetín) er 10 mg einu sinni á dag fyrir fullorðna yngri en 65 ára. NÝJU NG Vistor hf Hörgatún 2 210 Garðabær Sérlyfjatexti bls. 226

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