Læknablaðið - 01.12.1978, Side 26

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LÆKNABLAÐIÐ
ORÐALISTI
REAGIN PRÓF:
Nontreponemal próf, sem mæla reagin
mótefni (ekki Ig E). Þessi próf eru
ekki sérhæfð.
ART:
Automated reagin test. Sjálfvirkt próf,
sem er afbrigði af VDRL prófinu.
VDRL:
Veneral Disease Research Laboratory.
TREPONEMAL PRÓF:
Sérhæfð blóðvatnspróf til greiningar á
sárasótt.
FTA-ABS:
Fluorescent treponemal antibody ab-
sorption.
TPI:
Treponema pallidum immohilization.
TPHA:
Treponema pallidum hemagglutination
assay.
AMHA-TP:
Automated microhemagglutination to
Treponema pallidum.
ELISA:
Enzyme-linked immunosorbent assay.
BFP:
Biologic false positive. Táknar falskt
pósitift próf.
ÞAKKARORÐ
Við þökkum Arinbirni Kolbeinssyni, yfir-
lækni, og Birnu Oddsdóttur, meinatækni,
fyrir aðgang að niðurstöðum syphilisprófa
við Rannsóknastofu Háskólans. Sömuleiðis
þökkum við Kristínu Pálsdóttur fyrir vél-
ritun handrits.
SUMMARY
The control of veneral diseases in Iceland has
been centralized for several decades. The inci-
dence of primary and secondary syphilis 1950—
1975 is presented (Figure 1). The mean inci-
dence is 3.99/100.000. There are peaks in the
incidence rate 1950 and 1964, or at about the
same time as the peaks in other countries.
Serologic tests for syphilis, the Kahn and
Meinicke tests are done in The Serologic
Laboratorium of The University of Iceland and
the VDRL is used at The Blood Bank. A total
of 60.312 sera and 1.373 CSF specimens were
tested in The Serologic Laboratorium 1961—
1975. Of all reactive tests, 40—45% were con-
sidered false positive, without a confirmatory
treponemal test. This is a high precentage com-
pared to other studies. Three syphilis patients
have been found among donors during the last
ten yeares, resulting in one syphilis case in
eight to ten thousand donors.
The two relatively new treponemal tests,
TPHA and ELISA, seem to be promising in a
small community with a low incidence like Ice-
land, due to low cost and simplicity. Finally we
stress the importance of having a specific
treponemal test for syphilis.
HEIMILDIR
1. Coffey, E.M., Bradford, L.L., Naritomi, L.S.,
Wood, R.M.: Evaluation of the Qualitative
and automated Quantitative Microhemag-
glutination Assay for Antibodies to Trepo-
nema pallidum Appl. Microbiol. 24:26-30,
1972.
2. Cohen, P., Stout, G., Ende, N.: Serologic
reactivity in consecutive patients admitted
to a general hospital. Arch Intern Med 124:
364-367, 1969.
3. Cox, P.M., Logan, L.C., Norins, L.C.: Auto-
mated, Quantitative Microhemagglutination
Assay or Treponema pallidum Antibodies
Appl. Microbiol. 18:485-489, 1969.
4. Deacon, W.E., Lucas, J.B., Price, E.V.:
Fluorescent treponemal antibody-absorption
(FTA-ABS) test for syphilis. JAMA, 198.
624-628, 1966.
5. Duncan, W.C., Knox, J.M., Wende, R.D.:
The FTA-ABS test in dark-field positive
primary syphilis. JAMA 228:859-860, 1974.
6. Fiumara, N.J.: Biologic false-positive re-
aetion for syphilis. New Engl. J.Med. 268:
402-405, 1963.
7. Fleming, W.L., Brown, W.J., Donohue, J.F.,
Braningan, P.W.: National survey of vene-
ral disease treated by physicians in 1968.
JAMA 211:1827-1830, 1970.
8. Fowler, E., Gilbert, M.K., Allen, R.H.: A
comparison of four screening test for the
detection of syphilis. Canadian Journal of
Public Health 67:482-484, 1976.
9. Goldman, J.N., Lantz, M.A.: FTA-ABS and
VDRL slide test reactivity in a population
of nuns. JAMA 217:53-55, 1971.
10. Guðmundsson, H.: Veneral diseases in Ice-
land. Acta dermatovenerologica 31:412-418,
1951.
11. Harvey, A.M., Shulman, L.E.: Connective
tissue disease and the chronic biologic false-
positive serologic test for syphilis (BFP
reaction). Med Clin N Am 50:1271-1279,
1966.
12. Heilbrigðisskýrslur (Public health in Ice-
land): 1950—1975. Reykjavík.
13. Holmes, K.K.: Syphilis. In: Thorn, Adams,
Braunwald Isselbacher, Petersdorf: Harri-
son’s Principles of internal medicine (8th
ed.vol.l), McGraw-Hill, New York 1977, pp
917-928.
14. The inter-country spread of veneral dis-
eases — Report of a working group —
Copenhagen 7—10 December 1971. Regional
office for Europe, WHO Copenhagen, 1972.