Læknablaðið - 15.11.1989, Blaðsíða 11

LÆKNABLAÐIÐ
335
As the denominator in this definition is the whole
population, different age distributions introduce
a confounding factor. In this study correction is
made for possible age discrepancy by indirect
standardization using similar statistical methods
as have been described for »Standardized Mortality
Ratio« (SMR). Prescribed amount of drugs to the
study population was compared to that in Sweden
and the following formula was designed for
calculating the expected antimicrobial consumption
in the study area, had the age distribution been the
same as in Sweden:
(consumption in groupxpercentage of
groups inhabitants in the group).
The prescription rate was shown to be
85.5 prescriptions/1000 inhabitans/month.
Antimicrobials were significantly more often
prescribed to women compared to men (p<0.001).
Both absolute and relative figures showed the
highest prescription rate to the age group of 0-4
years.
When examining the amount measured in DDD
in relation to agegroups, it is evident that the the
antimicrobial prescribing to children does not
explain the observed difference in antimicrobial
usage between the two countries.
The total amount of antimicrobials prescribed was
23.5 DDD/1000 inhabitants/day. If age is corrected
to the Swedish population the rate increases to 26.5
DDD/1000/inhabitants/day. These results do not
support the study hypothesis.
The antimicrobial consumption in Sweden 1986
was 15.1 DDD/1000 inhabitants/day. This figure
can then be compared with the age correlated figure
of our study (26,5 DDD/1000 inhabitants/day),
demonstrating a »standardized DDD ratio« of 0.57
(p<0.05). These results emphasize the importance
of using indirect standardization especially when
comparing consumption of certain types of drugs
between populations.
It has been postulated that the age distribution of
the Icelandicpopulation changes in the future and
becomes similar to the distribution of the Swedish
population today. Therefore indirectly standardized
figure of 26.5 DDD/1000 inhabitants/day can be
explained as expected antimicrobial consumption in
Sudumes and Hafnarfjördur districts. This means
that if the doctors prescrip.tion habits will be
unchanged, we can expect increased antimicrobial
consumption in the future.
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