Læknablaðið - 15.03.1993, Blaðsíða 16

104
LÆKNABLAÐIÐ
molecule, or some part of it, into the cavity.
Such encapsulation of a drug molecule will
affect many of its physicochemical properties.
Cyclodextrins are shown to have effect on the
aqueous solubility of drugs and their delivery
through biological mentbranes, e.g. transcorneal
delivery of acetazolamide. Also, they can
increase both solubility and chemical stability
of many anticancer drugs. There are basically
two methods which can be used to increase the
transdermal delivery of drugs, i.e. by changing the
barrier function of the skin and by increasing the
availability of drugs at the skin surface. Penetration
enhancers, such as oleic acid and lauroylcholine
iodide, alter the skin barrier and thereby increase
the permeability of drugs into and through the
skin. Cyclodextrins do not penetrate the skin
barrier. Drug-cyclodextrin complexes deliver
drug molecules to the skin surface where they are
released before they partition into the skin.
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