Læknablaðið - 15.10.1993, Blaðsíða 7

LÆKNABLAÐIÐ
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Table 1. Characteristics of six patients treated with streptokinase for suspected acute myocardiai infarction.
Pre-SK*) symptom Hours to
Age Working time- Peak CK**) peak Clinical
Patient (years) diagnosis (hours) U/liter CK***) Response
1 64 Ant Ml 2 1/2 434 6 None, died 5 hours after SK.
2 63 Inf Ml 1 1/2 0 0 Pain improved Final diagnosis: Unstable
angina.
3 66 Ant Ml 1 1/2 2151 10 EKG+pain improved
4 79 Ant/lat Ml 2 1123 10 EKG+pain improved
5 64 Ant Ml 1 1/2 1900 14 EKG improved
6 61 Ant Ml 3 1/2 3405 18 EKG improved, reperfusion (?) arrhythmias
* SK=streptokinase, ** CK=creatin kinase,
*** Peak CK: samples were drawn every 4 hours from admission until 16 hours and then at 24 and 48 hours.
Table II. Plasminogen i, antiplasmin and fibrinogen i concentration in plasma from t ) males undergoing thrombolytic
therapy with streptokinase for acute myocardial infarction.
No Minutes from initiation of streptokinase infusion
patient 0 5 10 20 40 80
PLASMINOGEN 1 93 (100) 65 (70) 35 (38) 14 (15) 14 (15) 11 (12)
% of normal 2 74 (100) 52 (70) 22 (30) 15 (21) 13 (18) 8 (11)
plasma con- 3 92 (100) 80 (87) 63 (69) 25 (27) 17 (19) 14 (15)
centration. 4 100 (100) 70 (70) 25 (25) 12 (12) 12 (12) 6 (6)
(% of initial plasma 5 110 (100) 98 (89) 66 (60) 36 (33) 14 (13) 9 (8)
concentration) 6 115 (100) 80 (70) 66 (57) 40 (35) 16 (14) 11 (10)
Mean 97 74 (76) 46 (47) 24 (24) 19 (15) 10 (10)
± S.E.M. ±6 ±6 (±4) ±8 (±7) ±5 (±4) ±2 (±1) ±1 (±1)
ANTIPLASMIN 1 112 (100) 65 (58) 10 (4) 2 (2) 7 (6) 7 (6)
% of normal 2 90 (100) 40 (44) 5 (6) 4 (4) 5 (6) 5 (6)
plasma con- 3 120 (100) 80 (67) 35 (29) 5 (4) 1 (1) 6 (5)
centration. 4 118 (100) 28 (24) 13 (11) 5 (4) 4 (3) 7 (6)
(% of initial plasma 5 112 (100) 82 (73) 32 (29) 13 (12) 5 (5) 7 (6)
concentration) 6 90 (100) 25 (28) 18 (20) 12 (13) 3 (4) 1 (D
Mean 107 53 (49) 19 (17) 7 (7) 4 (4) 6 (5)
± S.E.M. ±6 ±11 (±8) ±5 (±4) ±2 (±2) ±1 (±1) ±1 (±1)
FIBRINOGEN 1 3.8 (100) 3.5 (92) 2. 3 (59) 0.3 (7) 0.2 (5) 0.3 (7)
g/i 2 4.7 (100) 4.2 (89) 2. 8 (59) 0.4 0) 0.4 (7) 0.4 (9)
(% of initial 3 3.7 (100) 3.1 (82) 3. 0 (80) 1.1 (30) 0.2 (4) 0.2 (5)
plasma con- 4 5.1 (100) 4.4 (86) 2. 5 (49) 0.3 (6) 0.4 (7) 0.3 (5)
centration) 5 2.6 (100) 2.5 (96) 2. 5 (96) 1.5 (58) 0.2 (8) 0.2 (8)
6 3.5 (100) 3.7(100) 3. 0 (86) 0.2 (6) 0.2 (6) 0.1 (3)
Mean 3.9 3.6 (91) 2. 7 (72) 0.6 (19) 0.3 (6) 0.3 (6)
± S.E.M. ±0.4 ±0.3 (±3) ±0. 1 (±8) ±0.2 (±9) ±0.0 (±D ±0.0 (±D