Læknablaðið - 15.04.2013, Side 23
TILFELLARÖÐ MEÐ YFIRLITI
Heimildir
1. Ferro JM, Canhao P, Stam J, Bousser MG,
Barinagarrementeria F; ISCVT Investigators. Prognosis
of cerebral vein and dural sinus thrombosis: results of
the Intemational Study on Cerebral Vein and Dural Sinus
Thrombosis (ISCVT. Stroke 2004; 35: 664-70.
2. Einhaupl K, Stam J, Bousser MG, de Bruijn SFTM, Ferro
JM, Martinelli I, et al. EFNS guideline on the treatment of
cerebral venous and sinus thrombosis in adult patients.
Eur J Neurol 2010; 17:1229-35.
3. Saposnik G, Barinagarrementeria F, Brown RD, Bushnell
CD, Cucchiara B, Cushman M, et al. Diagnosis and
Management of Cerebral Venous Thrombosis: A Statement
for Healthcare Professionals From the American Heart
Association/American Stroke Association. Stroke 2011; 42:
1158-92.
4. Elíasson JH, Valdimarsson EM, Jakobsson F. Dánarhlutfall
heilablóðfallssjúklinga á Sjúkrahúsi Reykjavíkur á ámnum
1996-1997. Læknablaðið 1999; 85: 517-25.
5. Bousser MG. Cerebral venous thrombosis: diagnosis and
management. J Neurol 2000; 247: 252-8.
6. De Bmijn SFTM, Stam J, Koopman MMW, Vandenbroucke
JP for the Cerebral Venous Sinus Thrombosis Study
Group. Case-control study of risk of cerebral sinus
thrombosis in oral contraceptive users and in carriers of
hereditary prothrombic conditions. BMJ1998; 316: 589-92.
7. Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci
PM. High risk of cerebral-vein thrombosis in carriers
of a prothrombin-gene mutation and in users of oral
contraceptives. N Eng J Med 1998; 338:1793-7.
8. Ameri A, Bousser MG. Cerebral venous thrombosis.
Neurol Clin 1992; 10 :87-lll.
9. Kenet G, Waldman D, Lubetsky A, Kombmt N, Khalil A,
Koren A, et al. Paediatric cerebral sinus vein thrombosis:
a multi-center, case controlled study. Thromb Haemost
2004; 92: 713-8.
10. Stam J. Thrombosis of the Cerebral Veins and Sinuses. N
Engl J Med 2005; 352:1791-8.
11. Cantu C, Barrinagarrimenteria F. Cerebral venous thromb-
osis associated with pregnancy and puerperium. Review
of 67 cases. Stroke 1993; 24:1880-4.
12. De Bmijn SFTM, Stam J, Kapelle LJ for the Cerebral
Venous Sinus Thrombosis Study Group. Thunderclape
headache as first symptom of cerebral venous sinus
thrombosis. Lancet 1996; 348:1623-5.
13. Mehraein S, Schmidtke K, Villringer A, Valdueza JM,
Masuhr F. Heparin treatment in cerebral sinus and venous
thrombosis: patients at risk of fatal outcome. Cerebrovasc
Dis 2003; 15:17-21.
14. Einhaupl KM, Masuhr F. Cerebral venous and sinus
thrombosis - an update. Eur J Neurol 1994; 1:109-26
15. Casey SO, Alberico RA, Patel M, Jimenez JM, Ozsvath RR,
Maguire WM, et al. Cerebral CT venography. Radiology
1996; 198:163-70.
16. Rodallec MH, Krainik A, Feydy A, Helias A, Colombani
JM, Julles MC, et al. Cerebral Venous Thrombosis
and Multi-detector CT Angiography: Tips and Tricks.
Radiographics 2006; 26: S5-S18.
17. Masuhr F, Mehraein S, Einhaupl KM. Cerebral venous and
sinus thrombosis. J Neurol 2004; 251:11-23.
18. Kosinski CM, Mull M, Schwarz M, Koch B, Biniek R,
Schláfer J, et al. Do normal D-dimer levels reliably exclude
cerebral sinus thrombosis? Stroke 2004; 35:2820-5.
19. Dentali F, Squizzato A, Marchesi C, Bonzini M, Ferro JM,
Ageno W. D-dimer testing in the diagnosis of cerebral vein
thrombosis: a systematic review and a meta-analysis of the
literature. J Thromb Haemost. 2012; 10: 582-9.
20. Coutinho J, de Bmijn SF, Deveber G, Stam J. Anti-
coagulation for cerebral venous sinus thrombosis.
Cochrane Database Syst Rev. 2011; 8: CD002005.
21. Einhaupl KM, Villringer A, Meister W, Mehraein S, Gamer
C, Pellkofer M, et al. Heparin treatment in sinus venous
thrombosis. Lancet 1991; 338:597-600.
22. de Bmijn SF, Stam J. Randomized, placebo-controlled trial
of anticoagulant treatment with low-molecular-weight
heparin for cerebral sinus thrombosis. Stroke 1999; 30:
484-8.
23. Misra UK, Kalita J, Chandra S, Kumar B, Bansal V. Low
molecular weight heparin versus unfractionated heparin
in cerebral venous sinus thrombosis: a randomized
controlled trial. Eur J Neurol 2012; 19:1030-6.
24. Coutinho JM, Ferro JM, Canhao P, Barinagarrementeria
F, Bousser MG, Stam J. Unfractionated or Low-Molecular
Weight Heparin for the Treatment of Cerebral Venous
Thrombosis. Stroke 2010; 41: 2575-80.
25. van Dongen CJ, van den Belt AG, Prins MH, Lensing AW.
Fixed dose subcutaneous low molecular weight heparins
versus adjusted dose unfractionated heparin for venous
thromboembolism. Cochrane Database Syst Rev 2004; 4:
CD001100.
26. Caprio F, Bemstein RA. Duration of Anticoagulation after
Cerebral Venous Sinus Thrombosis. Neurocrit Care 2012;
16:335-42.
27. Horowitz M, Purdy P, Unwin H, Carstens G, Greenlee R,
Hise J, et al. Treatment of dural sinus thrombosis using
selective catheterization and urokinase. Ann Neurol 1995;
38: 58-67.
28. Kim SY, Suh JH. Direct endovascular thrombolytic therapy
for dural sinus thrombosis: infusion of alteplase. AJNR
Am J Neuroradiol 1997; 18: 639-45.
29. Frey JL, Muro GJ, McDougall CG, Dean BL, Jahnke HK.
Cerebral venous thrombosis: combined intrathrombus
rtPA and intravenous heparin. Stroke 1999; 30:489-94.
30. Wasay M, Bakshi R, Kojan S, Bobustuc G, Dubey N, Unwin
DH. Nonrandomized comparison of local urokinase
thrombolysis versus systemic heparin anticoagulation for
superior sagittal sinus thrombosis. Stroke 2001; 32:2310-7.
31. Guo XB, Fu Z, Song LJ, Guan S. Local Thrombolysis for
Severe Cerebral Venous Sinus Thrombosis. AJNR Am J
Neuroradiol 2012; 33:1187-90.
32. Canhao P, Falcao F, Ferro JM. Thrombolytics for cerebral
sinus thrombosis: a systematic review. Cerebrovasc Dis
2003; 15:159-66.
33. Mehraein S, Schmidtke K, Villringer A, Valdueza JM,
Masuhr F. Heparin treatment in cerebral sinus and venous
thrombosis: patients at risk of fatal outcome. Cerebrovasc
Dis 2003; 15:17-21.
34. Tsai FY, Kostanian V, Rivera M, Lee KW, Chen CC,
Nguyen TH. Cerebral venous congestion as indication for
thrombolytic treatment. Cardiovasc Intervent Radiol 2007;
30: 675-87.
35. Borhani Haghighi A, Mahmoodi M, Edgell RC, Cruz-
Flores S, Ghanaati H, Jamshidi M, et al. Mechanical
Thrombectomy for Cerebral Venous Sinus Thrombosis:
A Comprehensive Literature Review. Clin Appl Thromb
Hemost 7. jan 2013. Epub ahead of print.
36. Dashti SR, Hu YC, Yao T, Fiorella D, Mitha AP,
Albuquerque FC, et al. Mechanical thrombectomy as
first-line treatment for venous sinus thrombosis: technical
considerations and preliminary results using the Angiojet
device. J Neurointerv Surg 2013; 5: 49-53.
37. Li G, Zeng X, Hussain M, Meng R, Liu Y, Yuan K, et al.
Safety and validity of mechanical thrombectomy and
thrombolysis on severe cerebral venous sinus thrombosis.
Neurosurgery 10. jan 2013. Epub ahead of print.
38. Canhao P, Cortesao A, Cabral M, Ferro JM, Stam J, Bousser
MG, et al, ISCVT Investigators. Are steroids useful to treat
cerebral venous thrombosis? Stroke 2008; 39:105-10.
39. Ferro JM, Crassard I, Coutinho JM, Canhao P,
Barinagarrementeria F, Cucchiara B, et al. Decompressive
surgery in cerebrovenous thrombosis: a multicenter
registry and a systematic review of individual patient
data. Stroke 2011; 42: 2825-31.
40. Rajan Vivakaran TT, Srinivas D, Kulkarni GB, Somanna S.
The role of decompressive craniectomy in cerebral venous
sinus thrombosis. J Neurosurg 2012; 117: 738-44.
41. Stefini R, Latronico N, Comali C, Rasulo F, Bollati A.
Emergent decompressive craniectomy in patients with
fixed dilated pupils due to cerebral venous and dural
sinus thrombosis: report of three cases. Neurosurgery
1999; 45: 626-9.
42. Borhani Haghighi A, Edgell RC, Cruz-Flores S, Feen E,
Piryawat P, Vora N. Mortality of cerebral venous-sinus
thrombosis in a large national sample. Stroke 2012; 43:
262-4.
ENGLISH SUMMARY
Cerebral sinus thrombosis - an uncommon but important differential
diagnosis to headache, stroke and seizures. Cases and overview
Sveinsson OA', Kjartansson O2, Valdimarsson EM3
Thrombosis of the cerebral veins and sinuses is an unusual but import-
ant cause of increased intracranial pressure and stroke, especially in the
young and middle aged. Pregnant women, especially during the puer-
perium, and individuals with thrombophilia are a special risk group. What
makes the diagnosis difficult is the vast range of symptoms including:
headache, nausea, vomiting, blurry vision, reduction of consciousness,
aphasia and motor and sensory disturbances. We present four cases
which reflect the diverse clinical presentation of the disease.
Key words: cerebral sinus thrombosis, raised intracranial pressure, stroke, anti-coagulation.
Correspondence: Olafur Sveinsson, olafur.sveinsson@karolinska.se
'Department of Neuroiogy Karolinska Hospital, Stockholm, Sweden, "Department of radiofogy, Landspítali, National University Hospital of lceland, Reykjavik, lceland, 3Depart-
ment of neurology, Landspitali, National University Hospital of lceland, Reykjavík, lceland.
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