Læknablaðið

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Læknablaðið - 15.02.2008, Page 15

Læknablaðið - 15.02.2008, Page 15
FRÆÐIGREINAR BRÁÐAR KRANSÆÐAR innan 60-120 mínútna frá því einkenni hefjast er bráð kransæðaþræðing besti kosturinn (20). Að öðrum kosti er segaleysandi meðferð hið rökrétta bráðaúrræði. Sú rannsókn sem hér er kynnt hefur ýmsar tak- markanir. Hún er afturskyggn og ekki nægilega fjölmenn eða umfangsmikil til að kanna hvaða afleiðingar tafir eða seinkuð viðbrögð hafa á afdrif sjúklinga. Upplýsingarnar eru takmarkaðar við það sem skráð var í sjúkra- og aðgerðarskýrslur og gagnaöflun úr sjúkraskrám var ekki sannreynd með annarri athugun. Aðeins hjá fáum sjúklingum voru tiltækar upplýsingar um tímann sem leið frá upphafi einkenna til upphafs meðferðar sem að sjálfsögðu ræður miklu um afdrif. Ekki voru heldur upplýsingar um flutningstíma eða hvaðan sjúklingar komu og því ekki unnt að bera saman sjúklinga eftir því hvort þeir komu um langan veg eða skamman. Ályktun Reynslan fyrsta árið af stöðugri vakt á Landspítala til að meðhöndla bráða kransæðastíflu með ST- hækkun með tafarlausri kransæðaþræðingu og kransæðavíkkun er mjög góð. Meðaltími frá inn- lögn til þræðingar er langt innan við alþjóðleg viðmiðunarmörk og fer í örfáum tilfellum yfir 90 mínútur. Meðallegutími er einnig stuttur og dán- artíðni lág. Heimildir 1. O'Neill W, Timmis GC, Bourdillon PD, et al. A prospective randomized clinical trial of intracoronary streptokinase versus coronary angioplasty for acute myocardial infarction. N Engl J Med 1986; 314: 812-8. 2. Grines CL, Browne KF, Marco J, et al. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. N Engi J Med 1993; 328: 673-9. 3. Zijlstra F, De Boer JM, Hoomtje JCA, Reiffers S, Reiber JHC, Suryapranata H. A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med 1993; 328: 680-4. 4. Berger PB, Ellis SG, Holmes DR, et al. Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction: results form the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes (Gusto- Ilb) trial. Circulation 1999; 100:14-20. 5. Ryan TJ, Antman EM, Brooks NH, et al. ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J Am Coll Cardiol 1999; 34: 890-911. 6. Van de Werf F, Ardissino D, Betriu A, et al. Management of acute myocardial infarction in patients presenting with ST- segment elevation. Task force of the ESC. Eur Heart J 2003; 24: 28-66. 7. Christopher PC, Gibson CM, Lambrew CT, et al. Relationship of symptom-onset-to-balloon time with mortality in patients undergoing angioplasty for myocardial infarction. JAMA 2000; 283: 2941-7. 8. De Luca G, Suryapranata H, Ottervanger JP, Antman EM. Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: every minute of delay counts. Circulation 2004; 109:1223-5. 9. McNamara RL, Wang Y, Herrin J, et al. Effect of door-to- balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol 2006; 108: 2828-30. 10. Jacobs AK, Antman EM, Ellrodt G, et al. Recommendation to develop strategies to increase the number of ST-segment- elevation myocardial infarction patients with timely access to primary percutaneous coronary intervention. Circulation 2006; 113: 2152-63. 11. Guðnason Þ, Þorgeirsson G, Eyjólfsson K, Jónmundsson EH. Tafarlaus kransæðavíkkun. Nýjung í meðferð bráðrar kransæðastíflu á íslandi. Læknablaðið 1996; 82:269-75. 12. Danielsen R, Eyjólfsson K, Sigurðsson AF, Jónmimdsson EJ. Árangur kransæðavíkkunaraðgerða á íslandi 1987-1998. Læknablaðið 2000; 86: 241-9. 13. Danielsen R, Eyjólfsson K. Frumárangur kransæðavíkkana hjá sjúklingum með sykursýki á íslandi. Læknablaðið 2004; 90: 227-32. 14. Pinto DS, Kirtane AJ, Nallamothu BK, et al. Hospital delays in reperfusion for ST-elevation myocardial infarction. Implications when selecting a reperfusion strategy. Circulation 2006; 114: 2019-25. 15. Krumholz HM, Anderson JL, Brooks NH, et al. ACC/ AHA clinical performance measures for adults with ST- elevation and non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task force on performance measures (Writing committee to develop performance measures on ST-elevation and non-ST-eievation myocardial infarction). Circulation 2006; 113: 732-61. 16. Keeley EC, Boura J, Grines C. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 2003; 361:13-20. 17. Huynh T, O'Laughlin J, Joseph L, et al. Delays to reperfusion therapy in acute ST-segment elevation myocardial infarction: results from the AMI-Quebeck Study. CMAJ 2006; 175:1527- 32. 18. Anderson HR, Nielsen TT, Rasmussen K, et al; for the DANAMI-2 Investigators. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med 2003; 349: 733-42. 19. Nallamothu BK, Bates ER, Herrin J, Wang Y, Bradley EH, Krumholz HM:for the NRMI Investigators. Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 analysis. Circulation 2005; 111: 761-7. 20. Nallamothu BK, Bradley EH, Krumholz HM. Time to treatment in primary percutaneous coronary intervention. N Engl J Med 2007; 357:1631-8. 21. Brindis RG; The challenges and pitfalls of door-to-balloon time as performance metric. ww.cardiosource.com/editorial, posted 14/6/2006. 22. Faxon D, Lenfant C: Time is everyting: Motivating patients to call 9-1-1 at onset of acute myocardial infarction. Circulation 2001; 104:1210-1. 23. Fibrinolytic Therapy Trialists (FTT) Collaborative Group: Indications for fibrinolytic therapy in suspected acute myocardial infarction: Collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 1994; 343:311-22. LÆKNAblaðið 2008/94 1

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