Læknablaðið - 01.11.2022, Side 16

492 L ÆKNABL AÐIÐ 2022/108
R A N N S Ó K N
E N G L I S H S U M M A R Y
Cardiac transplantation and donation in Icelandic patients - indications and outcome
INTRODUCTION: Information on the number, indications and outcome of cardiac transplantations in
Icelandic patients is scarce, as is information on the number of hearts donated from Iceland for cardiac
transplantation.
MATERIAL AND METHODS: A retrospective study on patients receiving heart transplantation from the first
procedure in 1988 until March 2019. Clinical information was gathered from Landspitali Transplantation
Clinic, patient charts, and information on donated hearts from the Icelandic Donation Registry. Age-
standardized incidence of the procedure was calculated, and overall survival (Kaplan-Meier) estimated.
Mean follow-up was 10.3 years.
RESULTS: Altogether 24 patients (19 males, median age 38 years, range: 4-65 years) underwent cardiac
transplantation; that included one re-transplantation, three simultaneous heart- and lung transplants and
two heart- and kidney transplants. The transplantations were performed in Gothenburg (n=20), London
(n=3) and Copenhagen (n=2). Most common indications were dilated cardiomyopathy (n=10), congenital
heart disease (n=4), and viral myocarditis (n=3). Five patients were bridged left ventricular-assist device
preoperatively. Overall survival at 1 and 5 years was 91% and 86%, respectively; median survival being
24 years. The incidence of cardiac transplantation was 2.7 heart-TX pmp/year but increased to 4.6
heart-TX pmp/year after 2008 (p=0.01). During the same period 42 hearts were donated from Iceland for
transplantation abroad, the first in 2002 and increasing from 0.8 to 3.0 hearts/year during the first and
second half of the study-period, respectively.
CONCLUSION: Survival of Icelandic cardiac transplant recipients is good and comparable to larger
transplant centers overseas. Number of hearts donated from Iceland have increased and currently Iceland
donates twice as many hearts at it receives.
doi 10.17992/lbl.2022.11.714
Atli Steinn Valgarðsson1
Þórdís Jóna Hrafnkelsdóttir2,3
Tómas Þór Kristjánsson3
Hildigunnur Friðjónsdóttir4
Kristinn Sigvaldason3,5
Göran Dellgren6
Tómas Guðbjartsson1,3
1Department of Cardiothoracic Surgery at Landspitali
University Hospital, 2Department of Cardiology
at Landspitali University Hospital, 3Faculty of
Medicine at University of Iceland, 4Transplant Clinic
at Landspitali University Hospital, 5Department of
critical Care and Anesthesia at Landspitali University
Hospital, 6Department of Cardiothoracic Surgery and
Transplantation at Sahlgrenska University Hospital.
Correspondence: Tómas Guðbjartsson,
tomasgud@landspitali.is
Key words: cardiac transplantation, heart transplant
donation, heart failure, survival, cardiac surgery, Iceland.
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