Læknablaðið - 15.02.2008, Síða 30

FRÆÐIGREINAR
STOFNFRUMUR
sóknir benda til að fínstjómun á hegðun frumna
sé háð nánu samspili við umhverfið. Allt eru þetta
krefjandi og viðamiklir þættir sem allir eru sam-
tvinnaðir.
Jafnvel þótt ígræðsla taugastofnfrumna yrði
ekki raunin í nánustu framtíð mun þekkingin sem
þessar rannsóknir skapa geta fært okkur margt
annað. Rannsóknir á stofnfrumum geta til dæmis
aukið þekkingu á uppruna og meingerð sjúkdóma
og gætu einnig flýtt fyrir lyfjaþróun.
Aður en rannsóknir fara fram á mönnum þarf
að sýna með óyggjandi hætti að árangur hafi náðst
með dýratilraunum. Einnig verður að hafa í huga
að árangur dýratilrauna tryggir ekki árangur
þegar kemur að mönnum. Jafnvel þó að grunn-
rannsóknir sýni árangur verður það ávallt próf-
steinninn hvort meðferðarformið geti minnkað
einkenni eða aukið lífsgæði sjúklinga með þessa
erfiðu og langvinnu sjúkdóma.
Þakkir
Höfundar þakka Ingvari Ólafssyni taugaskurð-
lækni fyrir yfirlestur og gagnlegar ábendingar.
Heimildir
1. Goldman SA, Nottebohm F. Neuronal production, migration,
and differentiation in a vocal control nucleus of the adult
female canary brain. Proc Natl Acad Sci USA1983; 80: 2390-
4.
2. Barkan S, Ayali A, Nottebohm F, Barnea A. Neuronal
recruitment in adult zebra finch brain during a reproductive
cycle. Dev Neurobiol 2007; 67: 687-701.
3. McKay R. Stem cells in the central nervous system. Science
1997; 276: 66-71.
4. Miller RH. The promise of stem cells for neural repair. Brain
Research 2006; 1091: 258-64.
5. Guðjónsson Þ, Steingrímsson E. Eiginleikar stofnfrumna:
frumusérhæfing og ný meðferðarúrræði. Læknablaðið 2003;
89: 43-8.
6. Gage H. Mammalian neural stem cells. Science 2000; 287:
1433-8.
7. Luskin MB. Restricted proliferation and migration of
postnatally generated neurons derived from the forebrain
subventricular zone. Neuron 1993; 11:173-89.
8. Lois C, Alvarez-Buylla A. Long-distance neuronal migration
in the adult mammalian brain. Science 1994; 264 :1145-8.
9. Curtis MA, Kam M, Nannmark U, et al. Human neuroblasts
migrate to the olfactory bulb via a lateral ventricular
extension. Science 2007; 315:1243-9.
10. Geraerts M, Krylyshkyna O, Debyser Z, Baekelandt V.
Concise review: therapeutic strategies for Parkinson disease
based on the modulation of adult neurogenesis. Stem Cells
2007; 25: 263-70.
11. Arvidsson A, Collin T, Kirik D, et al. Neuronal replacement
from endogenous precursors in the adult brain after stroke.
Nat Med 2002; 8: 963-70.
12. Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis
in the neocortex of adult mice. Nature 2000; 405: 951-5.
13. Shen Q, Goderie SK, Jin L, et al. Endothelial Cells Stimulate
Self-Renewal and Expand Neurogenesis of Neural Stem
Cells. Science 2004; 304:1338-40.
14. Palmer TD, Willhoite AR, Gage FH. Vascular niche for adult
hippocampal neurogenesis. J Comp Neurol 2000; 425: 479-
94.
15. Yin T, Linheng L. The stem cell niches in bone. J Clin Invest
2006; 116:1195-201.
16. Matssumo K, Yoshitomi H, Rossant J, Zare KS. Liver
organogenesis promoted by endothelial cells prior to
vascular function. Science 2001; 294: 559-63.
17. Lim DA, Alvarez-Buylla A. Interaction between astrocytes
and adult subventricular zone precursors stimulates
neurogenesis. Proc Natl Acad Sci USA1999; 96: 7526-31.
18. Laywell ED, Kukekov VG, Steindler DA. Multipotent
neurospheres can be derived from forebrain subependymal
zone and spinal cord of adult mice after protracted
postmortem intervals. Exp Neurol 1999; 156: 430-3.
19. Chmielnicki E, Benraiss A, Economides AN, Goldman
SA. Adenovirally expressed noggin and brain-derived
neurotrophic factor cooperate to induce new medium spiny
neurons from resident progenitor cells in the adult striatal
ventricular zone. J Neurosci 2004; 24: 2133-42.
20. Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy
for human neurodegenerative disorders - how to make it
work. Nature Med 2004; 10 (suppl.): 42-50.
21. Dezawa M, Kanno H, Hoshino M, et al. Specific induction
of neuronal cells from bone marrow stromal cells and
application for autologous transplantation. J Clin Invest
2004; 113:1701-10.
22. Takagi Y, Takahashi J, Saiki H, et al. Dopaminergic neurons
generated from monkey embryonic stem cells function in a
Parkinson primate model. J Clin Invest 2005; 115:102-9.
23. Björklund LM, Sanchez-Pernaute R, Chung S, et al.
Embryonic stem cells develop into functional dopaminergic
neurons after transplantation in a Parkinson rat model. Proc
Natl Acad Sci USA 2002; 99: 2344-9.
24. Kim JH, Auerbach JM, Rodriguez-Gomez JA, et al.
Dopamine neurons derived from embryonic stem cells
function in an animal model of Parkinson's disease. Nature
2002; 418: 50-6.
25. Levesque MF, Neuman T. Autologous transplantation
of differentiated dopaminergic neurons for Parkinson's
disease: long term post-operative, clinical and functional
metabolic results. Exp Neurol 2002; 175: 425.
26. Fallon J, Reid S, Kinyamu R, et al. In vivo induction of massive
proliferation, directed migration, and differentiation of
neural cells in the adult mammalian brain. Proc Natl Acad
Sci USA 2000; 97:14686-91.
27. Hoglinger GU, Rizk P, Muriel MP, et al. Dopamine depletion
impairs precursor cell proliferation in Parkinson disease.
Nat Neurosci 2004; 7: 726-35.
28. Freundlieb N, Francois C, Tande D, Oertel WH, Hirsch EC,
Hoglinger GU. Dopaminergic substantia nigra neurons
project topographically organized to the subventricular
zone and stimulate precursor cell proliferation in aged
primates. J Neurosci 2006; 26: 2321-5.
29. Van Kampen JM, Hagg T, Robertson HA. Induction of
neurogenesis in the adult rat subventricular zone and
neostriatum following dopamine D receptor stimulation.
Eur J Neurosci 2004; 19: 2377-87.
30. Wichterle H, Lieberam I, Porter JA, Jessell TM. Directed
differentiation of embryonic stem cells into motor neurons.
Cell 2002; 110: 385-97.
31. Li XJ, Du ZW, Zarnowska ED, et al. Specification of
motoneurons from human embryonic stem cells. Nat
Biotechnol 2005; 23: 215-21.
32. Kerr DA, Liado J, Shamblott M, et al. Human embryonic
germ cell derivatives facillitate motor recovery of rats with
diffuse motor neuron injury. J Neurosci 2003; 23: 5131-40.
33. Harper JM. et al. Axonal growth of embryonic stem cell-
derived motoneurons in vitro and in motoneuron-injured
adult rats. Proc Natl Acad Sci USA 2004; 101: 7123-8.
34. Miles GB, Yohn DC, Wichterle H, et al. Functional properties
of motoneurons derived from mouse embryonic stem cells.
J Neurosci 2004; 24: 7848-58.
35. Hugenholtz H, Cass DE, Dvorak MF, et al. High-dose
methylprednisolone for acute closed spinal cord injury
- only a treatment option. Can J Neurol Sci 2002; 29: 227-35.
Review.
36. Raisman G. Olfactory ensheathing cells- another miracle
cure for spinal cord injury? Nat Rev Neurosci 2001; 2: 369-
474.
37. McDonald JW, Liu XZ, Qu Y, et al. Transplanted embryonic
stem cells survive, differentiate and promote recovery in
injured rat spinal cord. Nat Med 1999; 5:1410-2.
38. Liu S, Qu Y, Stewart TJ, et al. Embryonic stem cells
differentiate into oligodendrocytes and myelinate in culture
and after spinal cord transplantation. Proc Natl Acad Sci
USA2000; 97: 6126-31.
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