Læknablaðið - 15.02.2008, Síða 38
FRÆÐIGREINAR
KRABBALÍKISÆXLI
Lokaorð
Krabbalíki í lungum hegða sér oftast eins og góð-
kynja æxli og langtíma lífshorfur þessara sjúklinga
eru yfirleitt mjög góðar. Sjúklingar með afbrigði-
lega vefjagerð eru oftar með útbreiddan sjúkdóm
og lífshorfur þeirra eru marktækt verri. Hins
vegar geta sjúklingar með dæmigerð krabbalíki
einnig haft meinvörp (14,8%) og sjúkdómurinn
leitt til dauða. Þess vegna getur vefjagerð þess-
ara æxla ekki talist áreiðanleg til að spá fyrir um
klíníska hegðun þeirra og margt bendir til þess að
miðmætisspeglun og jáeindaskönn séu mikilvæg
við mat á horfum.
Þakkir
Skurðlæknamir Hörður Alfreðsson og Bjarni
Torfason fá þakkir fyrir klínískar upplýsingar,
Helgi Sigvaldason verkfræðingur fyrir tölfræðiað-
stoð og Gunnhildur Jóhannsdóttir fyrir aðstoð
við öflun upplýsinga. Rannsóknin var styrkt af
Vísindasjóði Landspítala.
Heimildir
1. Rea F, Rizzardi G, Zuin A, et al. Outcome and surgical
strategy in bronchial carcinoid tumors: single institution
experience with 252 patients. Eur J Cardiothorac Surg 2007;
31:186-91.
2. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715
carcinoid tumors. Cancer 2003; 97: 934-59.
3. Cardillo G, Sera F, Di Martino M, et al. Bronchial carcinoid
tumors: nodal status and long-term survival after resection.
Ann Thorac Surg 2004; 77:1781-5.
4. Ferguson MK, Landreneau RJ, Hazelrigg SR, et al. Long-
term outcome after resection for bronchial carcinoid tumors.
Eur J Cardiothorac Surg 2000; 18:156-61.
5. Carretta A, Ceresoli GL, Arrigoni G, et al. Diagnostic and
therapeutic management of neuroendocrine lung tumors: a
clinical study of 44 cases. Lung Cancer 2000; 29: 217-25.
6. Hage R, de la Riviere AB, Seldenrijk CA, van den Bosch JM.
Update in pulmonary carcinoid tumors: a review article.
Ann Surg Oncol 2003; 10: 697-704.
7. Filosso PL, Rena O, Donati G, et al. Bronchial carcinoid
tumors: surgical management and long-term outcome. J
Thorac Cardiovasc Surg 2002; 123:303-9.
8. Fink G, Krelbaum T, Yellin A, et al. Pulmonary carcinoid:
presentation, diagnosis, and outcome in 142 cases in Israel
and review of 640 cases from the literature. Chest 2001; 119:
1647-51.
9. Marty-Ane CH, Costes V, Pujol JL, Alauzen M, Baldet P,
Mary H. Carcinoid tumors of the lung: do atypical features
require aggressive management? Ann Thorac Surg 1995;
59:78-83.
10. Mountain CF. Revisions in the Intemational System for
Staging Lung Cancer. Chest 1997; 111:1710-7.
11. el-Naggar AK, Ballance W, Karim FW, et al. Typical and
atypical bronchopulmonary carcinoids. A clinicopathologic
and flow cytometric study. Am J Clin Pathol 1991; 95: 828-
34.
12. Ducrocq X, Thomas P, Massard G, et al. Operative risk and
prognostic factors of typical bronchial carcinoid tumors. Ann
Thorac Surg 1998; 65:1410-4.
13. Mineo TC, Guggino G, Mineo D, Vanni G, Ambrogi V.
Relevance of lymph node micrometastases in radically
resected endobronchial carcinoid tumors. Ann Thorac Surg
2005; 80: 428-32.
14. Garcia-Yuste M, Matilla JM, Alvarez-Gago T, et al.
Prognostic factors in neuroendocrine lung tumors: a
Spanish Multicenter Study. Spanish Multicenter Study of
Neuroendocrine Tumors of the Lung of the Spanish Society
of Pneumonology and Thoracic Surgery (EMETNE-SEPAR).
Ann Thorac Surg 2000; 70: 258-63.
15. Skúladóttir H, Hirsch FR, Hansen HH, Olsen JH.
Pulmonary neuroendocrine tumors: incidence and prognosis
of histological subtypes. A population-based study in
Denmark. Lung Cancer 2002; 37:127-35.
16. E1 Jamal M, Nicholson AG, Goldstraw P. The feasibility
of conservative resection for carcinoid tumours: is
pneumonectomy ever necessary for uncomplicated cases?
Eur J Cardiothorac Surg 2000; 18: 301-6.
17. Jónasson JG. Krabbamein á íslandi. Krabbameinsfélag
íslands, 2004.
18. Cerfolio RJ, Deschamps C, Allen MS, Trastek VF, Pairolero
PC. Mainstem bronchial sleeve resection with pulmonary
preservation. Ann Thorac Surg 1996; 61:1458-62; discussion
1462-3.
19. Tastepe AI, Kurul IC, Demircan S, Liman ST, Kaya S, Cetin
G. Long-term survival following bronchotomy for polypoid
bronchial carcinoid tumours. Eur J Cardiothorac Surg 1998;
14: 575-7.
20. Stamatis G, Freitag L, Greschuchna D. Limited and radical
resection for tracheal and bronchopulmonary carcinoid
tumour. Report on 227 cases. Eur J Cardiothorac Surg 1990;
4: 527-32; discussion 533.
21. Ginsberg RJ, Rubinstein LV. Randomized trial of lobectomy
versus limited resection for T1 N0 non-small cell lung cancer.
Lung Cancer Study Group. Ann Thorac Surg 1995; 60: 615-
22; discussion 622-3.
22. Acker MR, Burrell SC. Utility of 18F-FDG PET in evaluating
cancers of lung. J Nucl Med Technol 2005; 33: 69-74; quiz 75-
7.
23. Perkins P, Kemp BL, Putnam JB, Jr., Cox JD. Pretreatment
characteristics of carcinoid tumors of the lung which predict
aggressive behavior. Am J Clin Oncol 1997; 20: 285-8.
24. Granberg D, Eriksson B, Wilander E, et al. Experience in
treatment of metastatic pulmonary carcinoid tumors. Ann
Oncol 2001; 12:1383-91.
25. Ekeblad S, Sundin A, Janson ET, et al. Temozolomide as
monotherapy is effective in treatment of advanced malignant
neuroendocrine tumors. Clin Cancer Res 2007; 13: 2986-91.
130 LÆKNAblaðið 2008/94