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Læknablaðið - 15.02.2008, Qupperneq 38

Læknablaðið - 15.02.2008, Qupperneq 38
FRÆÐIGREINAR KRABBALÍKISÆXLI Lokaorð Krabbalíki í lungum hegða sér oftast eins og góð- kynja æxli og langtíma lífshorfur þessara sjúklinga eru yfirleitt mjög góðar. Sjúklingar með afbrigði- lega vefjagerð eru oftar með útbreiddan sjúkdóm og lífshorfur þeirra eru marktækt verri. Hins vegar geta sjúklingar með dæmigerð krabbalíki einnig haft meinvörp (14,8%) og sjúkdómurinn leitt til dauða. Þess vegna getur vefjagerð þess- ara æxla ekki talist áreiðanleg til að spá fyrir um klíníska hegðun þeirra og margt bendir til þess að miðmætisspeglun og jáeindaskönn séu mikilvæg við mat á horfum. Þakkir Skurðlæknamir Hörður Alfreðsson og Bjarni Torfason fá þakkir fyrir klínískar upplýsingar, Helgi Sigvaldason verkfræðingur fyrir tölfræðiað- stoð og Gunnhildur Jóhannsdóttir fyrir aðstoð við öflun upplýsinga. Rannsóknin var styrkt af Vísindasjóði Landspítala. Heimildir 1. Rea F, Rizzardi G, Zuin A, et al. Outcome and surgical strategy in bronchial carcinoid tumors: single institution experience with 252 patients. Eur J Cardiothorac Surg 2007; 31:186-91. 2. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003; 97: 934-59. 3. Cardillo G, Sera F, Di Martino M, et al. Bronchial carcinoid tumors: nodal status and long-term survival after resection. Ann Thorac Surg 2004; 77:1781-5. 4. Ferguson MK, Landreneau RJ, Hazelrigg SR, et al. Long- term outcome after resection for bronchial carcinoid tumors. Eur J Cardiothorac Surg 2000; 18:156-61. 5. Carretta A, Ceresoli GL, Arrigoni G, et al. Diagnostic and therapeutic management of neuroendocrine lung tumors: a clinical study of 44 cases. Lung Cancer 2000; 29: 217-25. 6. Hage R, de la Riviere AB, Seldenrijk CA, van den Bosch JM. Update in pulmonary carcinoid tumors: a review article. Ann Surg Oncol 2003; 10: 697-704. 7. Filosso PL, Rena O, Donati G, et al. Bronchial carcinoid tumors: surgical management and long-term outcome. J Thorac Cardiovasc Surg 2002; 123:303-9. 8. Fink G, Krelbaum T, Yellin A, et al. Pulmonary carcinoid: presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest 2001; 119: 1647-51. 9. Marty-Ane CH, Costes V, Pujol JL, Alauzen M, Baldet P, Mary H. Carcinoid tumors of the lung: do atypical features require aggressive management? Ann Thorac Surg 1995; 59:78-83. 10. Mountain CF. Revisions in the Intemational System for Staging Lung Cancer. Chest 1997; 111:1710-7. 11. el-Naggar AK, Ballance W, Karim FW, et al. Typical and atypical bronchopulmonary carcinoids. A clinicopathologic and flow cytometric study. Am J Clin Pathol 1991; 95: 828- 34. 12. Ducrocq X, Thomas P, Massard G, et al. Operative risk and prognostic factors of typical bronchial carcinoid tumors. Ann Thorac Surg 1998; 65:1410-4. 13. Mineo TC, Guggino G, Mineo D, Vanni G, Ambrogi V. Relevance of lymph node micrometastases in radically resected endobronchial carcinoid tumors. Ann Thorac Surg 2005; 80: 428-32. 14. Garcia-Yuste M, Matilla JM, Alvarez-Gago T, et al. Prognostic factors in neuroendocrine lung tumors: a Spanish Multicenter Study. Spanish Multicenter Study of Neuroendocrine Tumors of the Lung of the Spanish Society of Pneumonology and Thoracic Surgery (EMETNE-SEPAR). Ann Thorac Surg 2000; 70: 258-63. 15. Skúladóttir H, Hirsch FR, Hansen HH, Olsen JH. Pulmonary neuroendocrine tumors: incidence and prognosis of histological subtypes. A population-based study in Denmark. Lung Cancer 2002; 37:127-35. 16. E1 Jamal M, Nicholson AG, Goldstraw P. The feasibility of conservative resection for carcinoid tumours: is pneumonectomy ever necessary for uncomplicated cases? Eur J Cardiothorac Surg 2000; 18: 301-6. 17. Jónasson JG. Krabbamein á íslandi. Krabbameinsfélag íslands, 2004. 18. Cerfolio RJ, Deschamps C, Allen MS, Trastek VF, Pairolero PC. Mainstem bronchial sleeve resection with pulmonary preservation. Ann Thorac Surg 1996; 61:1458-62; discussion 1462-3. 19. Tastepe AI, Kurul IC, Demircan S, Liman ST, Kaya S, Cetin G. Long-term survival following bronchotomy for polypoid bronchial carcinoid tumours. Eur J Cardiothorac Surg 1998; 14: 575-7. 20. Stamatis G, Freitag L, Greschuchna D. Limited and radical resection for tracheal and bronchopulmonary carcinoid tumour. Report on 227 cases. Eur J Cardiothorac Surg 1990; 4: 527-32; discussion 533. 21. Ginsberg RJ, Rubinstein LV. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 1995; 60: 615- 22; discussion 622-3. 22. Acker MR, Burrell SC. Utility of 18F-FDG PET in evaluating cancers of lung. J Nucl Med Technol 2005; 33: 69-74; quiz 75- 7. 23. Perkins P, Kemp BL, Putnam JB, Jr., Cox JD. Pretreatment characteristics of carcinoid tumors of the lung which predict aggressive behavior. Am J Clin Oncol 1997; 20: 285-8. 24. Granberg D, Eriksson B, Wilander E, et al. Experience in treatment of metastatic pulmonary carcinoid tumors. Ann Oncol 2001; 12:1383-91. 25. Ekeblad S, Sundin A, Janson ET, et al. Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors. Clin Cancer Res 2007; 13: 2986-91. 130 LÆKNAblaðið 2008/94
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