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Colon cancer in lceland 1955-2004. Study on epidemiology,
histopathology and gender difference
Objective: Colon cancer is the third most common
cancer in lceland. The aim of this study was to analyze
the epidemiology and histopathology of colon cancer in
lceland, resection rate and the difference between men
and women.
Material and methods: Pathology and autopsy reports
for all patients diagnosed with colon cancer between
1955 and 2004 where reviewed. All the histopathology
material was re-evaluated. Demographical information and
pathological findings were registered. Age-standardized
incidence was calculated for both men and women.
Gender difference was evaluated. Time trend was
evaluated by linear regression.
Results: After re-evaluation 2293 cases remained (1148
males and 1145 females). The incidence increased
for men from 7.5, to 22.2/105 and for women from 8.6
to 15.1/105. Most tumors were located in the sigmoid
colon (35%). Surgical rate increased from 50% to
85%. Adenocarcinomas where 84% and mucinous
adenocarcinoma 7%. Altogether 7% of cases were TNM-
stage I, 32% were stage II, 24% stage III, 21% in stage IV
and stage was unknown in 16% of cases. Slight gender
difference was observed regarding grade, vessel invasion,
depth of invasion and anatomic subsite.
Conclusion: Incidence of colon cancer increased
considerably, mainly for men. Surgical rate and pathology
of colon cancer is similar to that reported elsewhere except
that there are somewhat fewer cases in TNM-stage I.
Little gender difference was observed in the pathological
parameters analysed.
Snaebjornsson P, Jonasson L, Jonsson Th, Moller PH, Theodors A, Jonasson JG.
Colon cancer in lceland 1955-2004. Study on epidemiology, histopathology and gender difference. Icel Med J 2009; 95; 423-30
Key words: colon cancer, histopathology, epidemiology, gender, population-based.
Correspondence: Jón Gunntaugur Jónasson, jongj@landspitali.is
Barst: 3. febrúar 2009, - samþykkt til birtingar: 29. apríl 2009
430 LÆKNAblaðið 2009/95